A5043551392- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Infection Control in Healthcare
- Pneumonia and Respiratory Infections
- Liver Disease and Transplantation
- Respiratory viral infections research
- Reproductive tract infections research
- Biosensors and Analytical Detection
- Infective Endocarditis Diagnosis and Management
- Urinary Tract Infections Management
- Ethics in Clinical Research
- Liver Disease Diagnosis and Treatment
- Salmonella and Campylobacter epidemiology
- SARS-CoV-2 detection and testing
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Clinical practice guidelines implementation
Guy's and St Thomas' NHS Foundation Trust
2016-2025
King's College London
2016-2025
St Thomas' Hospital
2010-2024
St. Thomas Hospital
2014-2024
Oxford Nanopore Technologies (United Kingdom)
2023
The London College
2023
University Hospital of Lausanne
2021
University of Lausanne
2021
Imperial College London
2021
Groupe Français de Transplantation Fécale
2021
Interest in the therapeutic potential of faecal microbiota transplant (FMT) has been increasing globally recent years, particularly as a result randomised studies which it used an intervention. The main focus these treatment recurrent or refractory Clostridium difficile infection (CDI), but there is also emerging evidence base regarding applications non-CDI settings. key clinical stakeholders for provision and governance FMT services UK have tended to be two major specialty areas:...
Epidemiological and whole-genome sequencing analysis of an ongoing outbreak Streptococcus pyogenes (Group A Streptococcus) in London (United Kingdom).
Abstract Background Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening faeces donors are being embedded within regulatory frameworks described in European Union Tissue Cells Directive technical guide to quality safety tissue cells human application, published by Council. Objective Several international consensus statements concerning faecal...
Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the use, conduct, potential for FMT in Europe.We invited all hospital-based centres within European Council member states answer a web-based questionnaire covering their activities, organisation, regulation of 2019. Responders were identified from trials registered at clinicaltrials.gov United Gastroenterology (UEG) working group stool...
This paper describes the implementation of an efficient and accurate multiple scattering parameterization within lowtran fascode transmittance/radiance models. The is based on a stream approximation in which local radiance field needed to evaluate source function estimated from radiation fluxes. latter are calculated parameterized two-flux for individual layers adding method combining layers. Because line-by-line nature fascode, it straightforward implement treatment. For lowtran, interface...
Background Identifying and tackling the social determinants of infectious diseases has become a public health priority following recognition that individuals with lower socioeconomic status are disproportionately affected by diseases. In many parts world, epidemiologically genotypically defined community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) strains have emerged to frequent causes hospital infection. The aim this study was use spatial models adjustment for...
Abstract Background A cost effective and efficient diagnostic tool for COVID-19 as near to the point of care (PoC) possible would be a game changer in current pandemic. We tested reverse transcription loop mediated isothermal amplification (RT-LAMP), method which can produce results under 30 min, alongside standard methods real-life clinical setting. Methods This prospective service improvement project piloted an RT-LAMP on nasal pharyngeal swabs 21 residents high dependency home, with two...
Respiratory metagenomics (RMg) needs evaluation in a pilot service setting to determine utility and inform implementation into routine clinical practice.
Objectives To estimate the costs and benefits of clinical pathways incorporating a point care (POC) nucleic acid amplification test (NAAT) for chlamydia gonorrhoea in genitourinary medicine (GUM) clinics compared with standard off-site laboratory testing. Method We simulated 1.2 million GUM clinic attendees England. A simulation Microsoft Excel was developed to compare existing management POC NAAT. conducted scenario analyses evaluate robustness model findings. The primary outcome...
Carbapenemase-producing Enterobacteriaceae (CPE) are an emerging threat for healthcare providers worldwide.To determine CPE carriage rates and risk factors in unselected hospital cohort at the time of admission.We approached 4567 patients within 72 h admission to provide a rectal swab answer questionnaire on carriage. Rectal swabs were cultured carbapenem-resistant organisms chromogenic non-chromogenic agar, tested carbapenemase production by PCR (Check-Direct CPE). The study was approved...
The first British Society of Gastroenterology (BSG) and Healthcare Infection (HIS)-endorsed faecal microbiota transplant (FMT) guidelines were published in 2018. Over the past 5 years, there has been considerable growth evidence base (including publication outcomes from large national FMT registries), necessitating an updated critical review literature a second edition BSG/HIS guidelines. These have produced accordance with National Institute for Health Care Excellence-accredited...