A5032175608- Historical and Archaeological Studies
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Biosimilars and Bioanalytical Methods
- Diabetes Management and Research
- Acute Myocardial Infarction Research
- Social and Educational Sciences
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Education, Healthcare and Sociology Research
- Total Knee Arthroplasty Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Head and Neck Cancer Studies
- Pharmacovigilance and Adverse Drug Reactions
- Research in Social Sciences
- Cardiac Arrhythmias and Treatments
- Elbow and Forearm Trauma Treatment
- Cardiovascular Function and Risk Factors
- Pharmaceutical studies and practices
- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Gestational Diabetes Research and Management
Novo Nordisk (Denmark)
2014-2024
University of Colorado Denver
2023
Copenhagen University Hospital
2013-2021
Frederiksberg Hospital
2018-2021
Bispebjerg Hospital
1991-2020
University of Copenhagen
2013-2019
Brigham and Women's Hospital
2019
VIA University College
2019
Hvidovre Hospital
2018
Aarhus School of Architecture
2017-2018
Decreasing Health Care Spending Through Market Competition—a Case for the Rapid Adoption of Adalimumab Biosimilars
Obesity has been associated with increased risk of atrial fibrillation (AF), but whether this is also prevalent in younger individuals unknown. We therefore investigated the AF relation to body mass index (BMI) among young fertile women. By cross-linkage nationwide registers childbirth and hospitalization, we identified 271 203 women without prior who gave birth Denmark between 2004 2009. Body (kg/m2) was examined as a factor for using proportional hazard models. Mean age 30.6 years (4.7 SD)...
Abstract Aims/hypothesis The aim of this study was to evaluate the efficacy and safety oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes insufficiently controlled diet exercise alone. Methods Peptide Innovation for Early Diabetes Treatment (PIONEER) 11 trial double-blind, randomised, Phase IIIa conducted across 52 sites China region (mainland Taiwan), Hungary, Serbia Ukraine. Eligible participants were ≥18 years (≥20 had diagnosis HbA 1c 53–86...
Family history is an established risk factor for myocardial infarction (MI), but it not clear how this changes with number and gender of first-degree relatives MI. We used the entire Danish population to examine importance MI in siblings parents.This study a retrospective nationwide register-based cohort including registered all citizens diagnosed period 1978-2010. In we identified 7552 patients first-time The rate ratios (RR) calculated by Poisson models showed RR 4.30 (95% confidence...
Objectives Our aim was to assess the association between use of hormone replacement therapy (HRT) and risk new-onset atrial fibrillation (AF) after myocardial infarction. Design, Setting Participants We used Danish nationwide registers hospitalizations prescriptions identify all women admitted with infarction in period 1997 2009 no known diagnosis AF. Their overall HRT categories assessed. Multivariable Cox proportional hazards analysis calculate AF first year discharge, comparing use. Main...
To assess the impact of baseline characteristics on efficacy and safety oral semaglutide in Japanese patients with type 2 diabetes.In Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) 9 10 trials, were randomized to once-daily (3, 7, or 14 mg) a comparator (placebo subcutaneous liraglutide 0.9 mg PIONEER 9; once-weekly dulaglutide 0.75 10) 52 weeks, 5 weeks follow up. An exploratory analysis grouped each trial according glycated hemoglobin (HbA1c ; ≤8.0, >8.0-≤9.0, >9.0%), body mass...
Statins may decrease the risk of primary venous thromboembolism (VTE), that is, deep vein thrombosis (DVT) and pulmonary embolism (PE) but effect statins in preventing recurrent VTE is less clear. The aim this study was therefore to investigate association between statin therapy VTE.A prospective cohort study.All hospitals Denmark.All patients with a hospital diagnosis Denmark during 1997-2009 associated warfarin or heparin prescription were identified.Adjusted HR hospitalised (ie, fatal...
OBJECTIVE: To study the association between paternal exposure to methotrexate within 90-day period before pregnancy and congenital malformations stillbirth in offspring. METHODS: We conducted a nationwide register study. Our cohort consisted of all live births Denmark 1997 2011 identified from Medical Birth Registry. Methotrexate-exposed fathers were National Prescription From national Hospital Registry we paternity, births, stillbirths as well discharge diagnoses on malformations. RESULTS:...
This study addresses the clinical problems regarding access of wear debris to bone-implant interface and possible dissemination polyethylene (PE) particles distant organs. We inserted two implants into each knee 7 dogs allowing joint fluid with a 0.75 mm initial gap around implant. Hydroxyapatite (HA)-coated non-coated (Ti) titanium alloy were randomly allocated distal femoral condyle. PE repeatedly injected right 3 weeks after surgery for period 49 weeks, while only vehicle was left joint....
ABSTRACT Background Pregnant women are at an increased risk of venous thromboembolism (VTE). Risk factors for VTE among pregnant not sufficiently investigated. Purpose To examine pharmacological and non‐pharmacological during pregnancy (antepartum). Methods The population comprised all in Denmark aged 15–50 giving birth 2003–2010. Pregnancies were linked on individual level with national registers hospital admissions drug dispenses from pharmacies. first occurring antepartum was examined Cox...
Cardiovascular events (stroke or myocardial infarction) are often associated with poorer prognosis in younger, compared older individuals. We examined the associations between prepregnancy obesity and risks of infarction stroke young, healthy women.All Danish women giving birth during 2004-2009 without a history renal disease cardiovascular were identified from national registers followed for median time 4.5 years (interquartile range, 2.8-5.8). They grouped according to body mass index...
The efficacy and safety of oral semaglutide, the first glucagon-like peptide-1 receptor agonist, were investigated in patients with type 2 diabetes (T2D) Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) programme. current post-hoc exploratory subgroup analyses evaluated outcomes by background medication insulin regimen subgroups. Data from PIONEER 3–5, 7 8 trials receiving once-daily semaglutide (14 mg/flexibly dosed) or a comparator (placebo, sitagliptin 100 mg liraglutide 1.8 mg)...
Prescribing information instructs taking oral semaglutide (a glucagon-like peptide-1 analogue) in the fasting state, followed by a post-dose period of ≥ 30 min. This trial compared recommended dosing schedule with alternative schedules. was randomised, single-centre, multiple-dose, open-label, five-armed, parallel-group healthy subjects who received once-daily (3 mg for 5 days 7 days). Subjects (n = 156) were randomised to five schedules: 2-, 4-, or 6-h pre-dose fast 30-min (treatment arms:...
Background Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index ( BMI ) and risks of diabetes, hypertension, dyslipidemia apparently healthy, women have been insufficiently investigated, the aims this study. Methods Results Women giving birth during years 2004–2009, no history cardiovascular disease, renal insufficiency, pregnancy‐associated metabolic disorders, or were identified nationwide registers. categorized...
Aims: Registries on in-hospital drug use are sparse, especially those that can be linked to nationwide registries. In this study, we present and validate the Electronic Patient Medication module (EPM)—the electronic administrative database covering Capital Region of Denmark. Methods: The research (EPM-research) is an adaptation underlying for (EPM-clinic). validation study was comprised two sub-studies. Sub-study 1: Accordance registration between EPM-clinic EPM-research investigated by...
Long-term data on real life use of infliximab (IFX) for inflammatory bowel disease (IBD) are lacking. We studied prescription patterns during the first 16 years following marketing authorization. In a population-based cohort from North Denmark Region, all IBD patients exposed to IFX 1999 2014 were identified. A total 623 (210 with ulcerative colitis [UC] and 413 Crohn's [CD]) IFX. UC, age at exposure decreased by 10 months per calendar year (P < 0.05) study period. CD, duration time 7...
<h3>Aims/objectives</h3> This randomised, double-blind, parallel-group trial compared the effects of liraglutide 3.0 mg to placebo, both as adjunct diet and exercise, on obstructive sleep apnoea (OSA) severity body weight. <h3>Content</h3> Obese individuals (n = 359) without diabetes who had moderate or severe OSA were unwilling/unable use continuous positive airway pressure therapy randomised 1:1 placebo for 32 weeks (baseline characteristics: 48.5 years, males 71.9%, apnoea–hypopnoea index...
In a 12‐week double‐blind study with 36 patients major depressive episode (DSM‐III), paroxetine (Seroxat® Aropax® showed significantly quicker onset of efficacy on the Melancholia Scale, and better tolerance than imipramine. Plasma concentration analyses no clear concentration‐efficacy correlation in either treatment group. During long‐term seemed to be superior imipramine preventing relapse: both treatments were well tolerated. A significant between baseline plasma tryptophan: large neutral...
Summary Aims Whether overweight is a risk factor for cardiovascular disease in the absence of metabolic disorders remains under debate and largely unexamined young women. We evaluated myocardial infarction ischaemic stroke fertile women conditional on time‐dependent presence disorders. Materials methods From nationwide registers we identified all normal weight (body mass index [ BMI ] ≥ 18.5 to <25 kg m −2 ) ( 25 Danish giving birth from 2004 2009. Using multivariable Poisson regression...