A5010124335- Geophysical Methods and Applications
- Climate change and permafrost
- Ionosphere and magnetosphere dynamics
- Antimicrobial Peptides and Activities
- Cryospheric studies and observations
- Geophysical and Geoelectrical Methods
- Biochemical and Structural Characterization
- Solar and Space Plasma Dynamics
- Chemical Synthesis and Analysis
- Seismic Waves and Analysis
- Methane Hydrates and Related Phenomena
- Geomagnetism and Paleomagnetism Studies
- Hydrology and Watershed Management Studies
- Soil Moisture and Remote Sensing
- Advanced Chemical Sensor Technologies
- Wireless Communication Networks Research
- Healthcare cost, quality, practices
- Smart Materials for Construction
- Earthquake Detection and Analysis
- Sodium Intake and Health
- Ocean Waves and Remote Sensing
- Meta-analysis and systematic reviews
- Winter Sports Injuries and Performance
- Pregnancy and preeclampsia studies
- Satellite Communication Systems
University of Alaska Anchorage
2013-2024
Hvidovre Hospital
2015-2023
Copenhagen University Hospital
2021-2023
Technical University of Denmark
2015-2017
University of Copenhagen
2013-2015
Capital Region of Denmark
2015
Amager Hospital
2015
Providence College
2012-2014
The Ohio State University
1991-2002
Ross Laboratories (United States)
2002
Antimicrobial peptides (AMPs) are promising candidates for battling multiresistant bacteria. Despite extensive research, structure-activity relationships of AMPs not fully understood, and there is a lack structural data relating to in lipids. Here we present the NMR structure anoplin (GLLKRIKTLL-NH2 ) micellar environment. A vast library substitutions was designed tested antimicrobial hemolytic activity, as well changes lipid interactions. This showed that improvement activity without...
To investigate the predictive performance of Fetal Medicine Foundation (FMF) first-trimester screening algorithm for pre-eclampsia in a Danish population and compare with that current strategy, which is based on maternal risk factors.
Abstract Thermokarst lakes accelerate deep permafrost thaw and the mobilization of previously frozen soil organic carbon. This leads to microbial decomposition large releases carbon dioxide (CO 2 ) methane (CH 4 that enhance climate warming. However, time scale permafrost-carbon emissions following is not well known but important for understanding how abrupt impacts feedback. We combined field measurements radiocarbon dating CH ebullition with (a) an assessment lake area changes delineated...
Retrospective studies suggest that for patients with ulcerative colitis (UC) combination therapy low-dose azathioprine and allopurinol (L-AZA/ALLO) may result in higher remission rates than monotherapy (AZA). We prospectively investigated the effects of these drugs moderate-to-severe UC.
We present the antimicrobial and hemolytic activities of decapeptide anoplin 19 analogs thereof tested against methicillin‐resistant Staphylococcus aureus ATCC 33591 (MRSA), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa 27853), vancomycin‐resistant Enterococcus faecium 700221) (VRE), Candida albicans 200955). The contain substitutions in amino acid positions 2, 3, 5, 6, 8, 9, 10. use these peptides to study effect altering charge hydrophobicity on activity red blood cells...
ABSTRACT Microbial resistance is an increasing health concern and a true danger to human well-being. A worldwide search for new compounds ongoing, antimicrobial peptides are promising lead candidates tomorrow's antibiotics. The decapeptide anoplin (GLLKRIKTLL-NH 2 ) especially interesting candidate because of its small size as well nonhemolytic properties. Optimization the properties peptide such requires multidimensional searching in complex chemical space. Typically, optimization performed...
An important component of ice sheet mass balance calculations is the snow accumulation rate, traditionally determined across from interpolated core data. We derive an rate map within Greenland dry‐snow facies, using C‐band radar backscatter and mean annual temperature. Values for were obtained ERS‐1 synthetic aperture mosaic acquired during September–November 1992. empirical equation, based on elevation latitude, used to determine examine influence temperature (5.3 GHz) backscatter, a...
VHF coherent scatter radar observations of an auroral substorm over Alaska are analyzed in the context multibeam incoherent plasma density and drifts data green‐line all‐sky optical imagery. Coherent arises from Farley Buneman waves which excited E region whenever convection electric field is greater than about 20 mV/m. Aperture synthesis imaging other aspects methodology facilitate precise spatial registration with coincident measurements. Discrete arcs were found to separate diffuse...
Abstract Sporadic E ionization layers have been observed in the daytime subauroral ionospheric layer by a 30 MHz radar Alaska. The detects coherent backscatter from meter‐scale field‐aligned plasma density irregularities. irregularities were generated modification—by emission of strong HF electromagnetic waves directly beneath layers—making visible to radar. Aperture‐synthesis methods are used generate imagery data. patchy, with patches organized along fronts spaced tens kilometers and...
Low-Earth orbiting (LEO) satellites now can provide broadband service anywhere in the world, but they must share radio spectrum with geosynchronous Earth-orbiting (GEO) satellites. The United Nations International Telecommunications Union (ITU) and U.S. Federal Communications Commission (FCC) require that operators of LEO satellite systems avoid interfering GEO even though both use same bands within spectrum. Such interference occur when a passes through an area between earth station its...
Abstract Coherent radar backscatter spectra from auroral E region plasma irregularities can be measured with great precision and accuracy. The Doppler obtained those measurements used to estimate convection patterns using an empirical model. These estimates are consistent rocket, optical, incoherent scatter data, but direct comparison between the different data sets is not straightforward. In order establish quality of model, alternative approaches then needed. this work, we use...
Reductions in salt intake have the potential to markedly improve population health at low cost. Real life interventions that explore feasibility and effects of a gradual reduction lasting least four weeks are required. The randomized controlled SalT Reduction InterVEntion (STRIVE) trial was developed investigate metabolic, behavioral months consuming gradually reduced bread alone or combination with dietary counselling. This paper describes rationale methods STRIVE. Aiming 120 healthy...
Abstract Coastal aquifers play an important role in marine ecosystems by providing high fluxes of nutrients and solutes via submarine groundwater discharge pathways. The physical chemical characterization these dynamic systems is foundational to understanding the extent magnitude hydrogeologic processes their subsequent contributions environment. We describe a km‐scale experimental field site located glaciofluvial delta entering Kachemak Bay, Alaska. Our applies geophysical (ERT HVSR),...
Objective Healthcare costs, including costs for laboratory tests, are increasing worldwide. One example is the measurement of vitamin D. General practitioners in Capital Region Denmark include a D status approximately 20% all requisitions. This study intended to examine effect compulsory pop-up form electronic request system on number tests and monitor indications.Design From 1 January 2017, we introduced which general had state indication measuring D, choosing from predefined set...
The aim was to examine the effects of two different salt reduction strategies on selected cardiovascular risk factors. study a four-month cluster randomised controlled study. Eighty-nine healthy Danish families (309 individuals) were randomly assigned either (A) gradually salt-reduced bread, (B) bread and dietary counselling further reduce intake increase potassium or (C) standard (control). effect assessed using linear mixed models. Intention treat analyses comparing changes in three groups...
Low-Earth orbiting (LEO) satellites now hold promise to provide broadband service anywhere in the world, but they must share radio spectrum with geosynchronous Earth-orbiting (GEO) satellites. The United Nations International Telecommunications Union (ITU) and U.S. Federal Communications Commission (FCC) require that operators of LEO satellite systems avoid interfering GEO even though both use same bands within spectrum. Such interference can occur when a passes through an area between earth...
The inclusion of peptoid monomers into antimicrobial peptides (AMPs) increases their proteolytic resistance, but introduces conformational flexibility (reduced hydrogen bonding ability and cis/trans isomerism). We here use NMR spectroscopy to answer how the insertion a monomer influences structure regular α-helical AMP upon interaction with dodecyl phosphocholine (DPC) micelle. Insertion [(2-methylpropyl)amino]acetic acid in maculatin-G15 shows that structural change depends on site...
As healthcare costs continue to rise throughout the world, critical assessment of appropriateness expenses gain focus.We aimed describe developments in test numbers 10 most frequently requested tests, and simulate effect introducing minimal retesting intervals.Data from blood tests - albumin, alanine transaminase, cholesterol, creatinine, C-reactive protein, hemoglobin, hemoglobin A1c, potassium, sodium, thyrotropin 2,687,589 patients handled by Capital Region Denmark 2010 2019 was used....
Abstract In order to test the efficacy of a cold-region evapotranspiration (ET) landfill cover against conventional compacted clay (CCL) cover, two pilot scale covers were constructed in side-by-side basin lysimeters () at site Anchorage, Alaska. The primary basis comparison between was percolation moisture from bottom each lysimeter. Between 30 April 2005 and 16 May 2006, 51.5 mm water percolated ET lysimeter, compared 50.6 for CCL This difference not found be significant 95% confidence...
Hemoglobin A1c (HbA1c) is a long-term measure for glucose concentration in plasma. Since its introduction as diabetes monitoring tool, and more recent application diagnostic the number of measurements HbA1c have risen dramatically. However, change slow, so repeating should not be done too often. We use large, unfiltered dataset from 52,017 patients to determine possible rate concentration. In our laboratory, critical difference between 8.5%. Our data show that 1-unit rise takes 4 weeks...
Temporal atmospheric pressure variations introduce an artifact into percolation measurements in free‐draining lysimeters. This anomaly is associated with transient gradients that occur as fluid and gas pressures within the lysimeter equilibrate changes at drain. On basis of harmonic (Fourier) analysis a large (20 m × 10 1.8 m) lysimeter, hourly was maximally affected by ∼2 cycles per day, effect decreasing frequency. Compared to calculated differences drain, measured phase delay between less...