A5009512873- Inflammatory Bowel Disease
- Microscopic Colitis
- Neurological disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Parkinson's Disease and Spinal Disorders
- Diverticular Disease and Complications
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Genetic Neurodegenerative Diseases
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Cytomegalovirus and herpesvirus research
- Tuberculosis Research and Epidemiology
Aalborg University
2022-2025
Aarhus University
2021-2024
Predict (France)
2022
Abstract Background Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), affect millions of people worldwide with increasing incidence. Objectives Several studies have shown a link between gut microbiota composition IBD, but results are often limited by small sample sizes. We aimed to re‐analyze publicly available fecal data from IBD patients. Methods extracted original 16S rRNA amplicon sequencing 45 cohorts patients healthy individuals using the...
Understanding the biological changes that precede a diagnosis of inflammatory bowel disease (IBD) could facilitate pre-emptive interventions, including risk factor modification, but this pre-clinical phase remains poorly characterized. Using measurements from 17 hematological and biochemical parameters taken up to 10 years before in over 20,000 IBD patients population controls, we address at massive scale. We observe widespread significant multiple occur 8 Crohn's (CD) 3 ulcerative colitis....
Abstract Background Despite major advances in our understanding of the molecular underpinning IBD, we remain challenged deciphering observed disease heterogeneity. Attempts to characterise longitudinal behaviour have either been restricted symptom-based profiling - as exemplified IBSEN cohorts or reliance on stochastic endpoints “progression” such hospitalisation, surgery and fibrosis. Here present a novel method examine IBD by modelling inflammatory patterns two large, well-characterised...
Accumulation of aggregated alpha-synuclein (α-syn) is believed to play a pivotal role in the pathophysiology Parkinson's disease (PD) and other synucleinopathies. As key constituent Lewy pathology, more than 90% α-syn bodies phosphorylated at serine-129 (pS129) hence, it used extensively as marker for pathology. However, exact pS129 remains controversial kinase(s) responsible phosphorylation have yet be determined. In this study, we investigated effect Polo-like kinase 2 (PLK2) inhibition on...
This Danish nationwide genome-wide association study aims to identify biomarkers of severe vs less ulcerative colitis.
Abstract Background Pediatric-onset ulcerative colitis (pUC) represents a more aggressive disease phenotype compared with adult-onset UC. We hypothesized that this difference can, in part, be explained by the composition of microbiota. Methods In prospective, longitudinal study, we included pediatric (N = 30) and adult patients newly or previously (>1 year) diagnosed analyzed microbiota mucosa-adherent at baseline, using 16S rRNA gene sequencing, fecal baseline 3-month intervals,...
Abstract Accumulation of aggregated alpha-synuclein (α-syn) is believed to play a pivotal role in the pathophysiology Parkinson’s disease (PD) and other synucleinopathies. α-Syn key constituent protein Lewy pathology, α-syn phosphorylated at serine-129 (pS129) constitutes more than 90% bodies hence, it used extensively as pathological marker for form α-syn. However, exact pS129 remains controversial well kinase(s) responsible phosphorylation. In this study, we investigated effect Polo-like...
ABSTRACT Background Infectious mononucleosis (IM) is a largely self-limiting syndrome mainly affecting adolescents and young adults but can present as more severe disease requiring hospitalisation. The infectious agent most commonly causing IM, Epstein-Barr virus (EBV) has been associated with the development of several immune-mediated inflammatory diseases. Objective To investigate risk bowel (IBD) following hospitalisation IM. Methods Danish nationwide registries were used to identify IM...
Abstract Background Genetic susceptibility to inflammatory bowel disease (IBD) has been widely studied, whereas the genetic contribution progression over time remains largely unknown. In a unique population-based cohort, we explored if IBD associated with course severity. Methods Danish nationwide cohort of 3688 patients Crohn’s (CD), 4491 ulcerative colitis (UC), and 9469 controls, estimated polygenic scores (PGS) for susceptibility. We then investigated association between PGS severe...