Abstract Background Currently, much of Africa’s inflammatory bowel disease (IBD) epidemiology status is unknown.1 While a few observational studies suggest rise in incidence, alternative methods are necessary to gather widespread data on IBD until systematically collected health become available. Google Trends has been used study specific diseases and symptoms through an epidemiological lens, knowledge its capabilities continues expand the healthcare field.2 maintained between 92-97.5%...

Abstract Background Evidence suggest that about 10-30% of individuals with COVID-19 develop a chronic condition following the acute phase, now referred to as post-acute sequalae (PASC) or long COVID1,2. Dysregulation immune system and inflammation, which are among primary drivers PASC3, at heart immune-mediated inflammatory disease (IMID) pathology. As PASC still remains underexplored in IMID population, we aimed carry out population-based cohort study estimate risk patients IMIDs compared...

Patients receiving immunosuppressives have been excluded from trials for SARS-CoV-2 vaccine efficacy. Investigation of immunosuppressants' impact on effectiveness vaccines, particularly in patients with immune-mediated inflammatory diseases (IMID), is therefore required.

ABSTRACT Introduction Inflammatory bowel disease (IBD) is associated with various extra-intestinal manifestations. We aim to identify comorbidities in IBD and the timing of their development provide valuable insight into mechanisms under-lying IBD. Methods conducted a population– disease-wide phenomic association study IBD, using > 6 million ICD-10 coded healthcare contacts from 10 years before up-to 17 after diagnosis investigate associations 1583 comorbidities. To explore diseases...

Human immunodeficiency virus (HIV) infection is associated with several immune-mediated disorders. However, the risk of inflammatory bowel disease (IBD) in people living HIV (PLWH) remains unclear. We aimed to assess IBD among PLWH using a nationwide, population-based Danish cohort and validate findings large American insurance-based database.

Summary Background Escalation to anti‐tumour necrosis factor (anti‐TNF) in inflammatory bowel disease (IBD) patients on thiopurine is a common clinical scenario. However, the impact of discontinuing at escalation unclear. Aim To assess versus continuing therapy anti‐TNF initiation. Methods We used Danish registries establish national cohort with IBD prior initiating from 2003 2018. compared within 90 days initiation those continuing. Our primary outcome was composite any new oral...

Abstract Background Patients with inflammatory bowel disease (IBD) are at increased risk of human papillomavirus (HPV) related cancers such as anal squamous cell carcinoma. However, non‐malignant HPV infection has never been systematically studied in IBD. This study aims to assess the genital warts (GW) IBD patients. Methods Using Danish nationwide registries, we identified 49,163 patients between 1996 and 2018 matched them 491,665 individuals from general population by age, sex,...

Abstract Background Inflammatory bowel disease (IBD), including Crohn’s (CD) and ulcerative colitis (UC), is known to be associated with various extra-intestinal manifestations, impacting organ systems beyond the gastrointestinal tract. Identifying comorbidities in IBD timing of their development can provide valuable insight into mechanisms underlying development. Methods We conducted first population- disease-wide phenomic association study IBD, using >6 million ICD-10 coded...

Abstract Background Viral infections have been implicated in the exacerbation of immune-mediated inflammatory diseases like bowel disease (IBD). The COVID-19 pandemic, therefore, sparked interest whether infection with virus has an adverse effect on course IBD. Since existing evidence is conflicting and limited by a small sample size, we performed very first meta-analysis to study long-term impact SARS-CoV-2 Methods We systematic literature search MEDLINE EMBASE for studies that explored...

Abstract Background Epstein-Barr virus (EBV) infects ~95% of adults globally and limited early life transmission opportunities can delay EBV exposure till adolescence/early adulthood, increasing the risk severe infection, which most commonly manifests as infectious mononucleosis (IM). This study sought to investigate a potential aetiological association between IM inflammatory bowel disease (IBD). Methods In this longitudinal nested case-control study, Danish nationwide registries were used...

ABSTRACT Background Infectious mononucleosis (IM) is a largely self-limiting syndrome mainly affecting adolescents and young adults but can present as more severe disease requiring hospitalisation. The infectious agent most commonly causing IM, Epstein-Barr virus (EBV) has been associated with the development of several immune-mediated inflammatory diseases. Objective To investigate risk bowel (IBD) following hospitalisation IM. Methods Danish nationwide registries were used to identify IM...

<title>Abstract</title> Background There is little to no evidence on the status of inflammatory bowel disease (IBD) in Africa. Due a lack epidemiological data for continent, alternative methods are necessary gather information IBD. Google Trends has been used study specific diseases and symptoms through an lens, knowledge its capabilities continues expand healthcare field. Objective The aim this was analyze 15-years IBD Search Interest throughout Africa characterize rapidly increasing...