A5069496557- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Brain Tumor Detection and Classification
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Histone Deacetylase Inhibitors Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Optical Imaging and Spectroscopy Techniques
- Colorectal Cancer Surgical Treatments
- Nutrition and Health in Aging
- Sarcoma Diagnosis and Treatment
- Diet and metabolism studies
- Boron Compounds in Chemistry
- European Cultural and National Identity
Rigshospitalet
2015-2025
Aarhus University Hospital
2021-2025
Copenhagen University Hospital
2009-2024
University Clinical Center Tuzla
2024
University Clinical Centre
2024
University of Copenhagen
2012-2018
Capital Region of Denmark
2009
Background/Objectives: Squamous cell lung cancer (SCC) presents a significant treatment challenge due to its poor prognosis and limited therapeutic options. In many resource-limited countries, access advanced molecular testing is often unavailable, making the identification of novel reliable prognostic markers crucial for improving patient selection systemic treatments. Methods: This single-center, retrospective study investigated value inflammatory biomarkers, including immune-inflammation...
Merkel cell carcinoma (MCC) is a rare, aggressive, skin cancer of obscure histogenesis, the incidence which rising. There no consensus on optimal treatment. Our aim was to evaluate staging, investigation, treatment, and follow-up MCC in eastern Denmark, investigate incidence. We suggest guidelines for First we reviewed medical records 51 patients diagnosed with from 1995 until 2006 Denmark. The nation-wide extracted Danish Cancer Registry calculations period 1986-2003. reviwed published...
Extracranial metastases from glioblastoma are rare. We report two patients with extracranial glioblastoma. Case 1 concerns a 59-year-old woman multiple that spread early in the course of disease. What makes this case unusual is tumor had grown into falx close to straight sinus and might be an explanation extensive metastases. 2 presents 60-year-old man liver metastasis found at autopsy, and, case, it more difficult find explanation. This patient spontaneous intracerebral bleeding incidents...
Background. Surgery followed by radiotherapy and concomitant adjuvant temozolomide is standard therapy in newly diagnosed glioblastoma multiforme (GBM). Bevacizumab combined with irinotecan produces impressive response rates recurrent GBM. In a randomized phase II study, we investigated the efficacy of neoadjuvant bevacizumab (Bev-Iri) versus (Bev-Tem) before, during after GBM.Material methods. After surgery, patients were to Bev-Iri or Bev-Tem for eight weeks, (60 Gy/30 fractions) another...
Longterm survival after curative resection for adenocarcinoma at the gastro-esophageal junction (GEJ) range between 18% and 50%. In pivotal Intergroup-0116 Phase III trial by Macdonald et all, adjuvant chemoradiotherapy improved both disease-free overall in curatively resected patients with mainly gastric adenocarcinoma. We compared data adeno-carcinoma solely (GEJ), treated surgery alone or chemoradio-therapy.From 2003 to 2009, 211 underwent resection. Surgery was performed 95 pa-tients 116...
The Danish Neuro Oncology Group (DNOG) has established national consensus guidelines for the delineation of organs at risk (OAR) structures based on published literature. This study was conducted to finalise these and evaluate inter-observer variability delineated OAR by expert observers.The DNOG were formed participants from all centres that treat brain tumours with radiotherapy. In a two-day workshop, discussed finalised pilot study. Following this, ten contoured following OARs T1-weighted...
Background Glioblastoma patients administered standard therapies, comprising maximal surgical resection, radiation therapy with concomitant and adjuvant temozolomide, have a variable prognosis median overall survival of 15–16 months 2-year 30%. The aim this study was to develop prognostic nomogram for glioblastoma treated outside clinical trials. Methods included 680 consecutive, non-selected as primary treatment between the years 2005 2016 at Rigshospitalet, Copenhagen, Denmark. model...
We evaluated the results of limb-sparing surgery and reconstruction bone defects with vascularized fibula grafts in 8 consecutive patients (mean age at operation 13.6 years (range 4.1–24.2 years), female/male = 6/2) sarcomas (BS) (osteosarcoma/Ewing's sarcoma/chondrosarcoma= 4/3/1) operated on form 2000 to 2006. The reconstructed were proximal femoral diaphysis epiphysis (<mml:math...
Both amino acid positron emission tomography (PET) and magnetic resonance imaging (MRI) blood volume (BV) measurements are used in suspected recurrent high-grade gliomas. We compared the separate combined diagnostic yield of simultaneously acquired dynamic contrast-enhanced (DCE) perfusion MRI O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET) PET patients with anaplastic astrocytoma glioblastoma following standard therapy.A total 76 lesions 60 hybrid [18F]FET PET/MRI scans DCE from recurrence...
Abstract Background This Danish cohort study aims to (1) compare patterns of care (POC) and survival patients with multifocal glioblastoma (mGBM) those unifocal (uGBM), (2) explore the association patient-related factors treatment assignment prognosis, respectively, in subgroup mGBM patients. Methods Data on all adults newly diagnosed, pathology-confirmed GBM between 2015 2019 were extracted from Neuro-Oncology Registry. To POC uGBM, we applied multivariable logistic Cox regression analysis,...
Abstract Background O-(2-[ 18 F]fluoroethyl)- l -tyrosine positron emission tomography ([ F]FET PET) scanning is used in routine clinical management and evaluation of gliomas with a recommended 4 h prior fasting. Knowledge test–retest variation [ PET imaging uptake metrics the impact accidental protein intake can be critical for interpretation. The aim this study was to investigate repeatability F]FET-PET assess protein-intake gliomas. Results Test–retest variability non-protein group good...
Patients with lower-grade gliomas are long-term survivors after radiotherapy and may benefit from the reduced dose to normal tissue achievable proton therapy. Here, we aimed quantify differences in uninvolved brain contralateral hippocampus compare risk of radiation-induced secondary cancer for photon plans glioma patients.Twenty-three patients were included this in-silico planning comparative study had calculated (50.4 Gy(RBE = 1.1), 28 Fx) applying similar constraints target organs at...
AbstractBackground The aim of this retrospective registry-based Danish patterns care study was (1) to evaluate the real-world utilisation short-course hypofractionated radiotherapy (HFRT) in glioblastoma (GBM) patients over time, and (2) impact HFRT by assessing trends multimodality treatment utilisation, compliance, outcome.Material methods Data all adults with newly diagnosed pathology-confirmed GBM between 2011 2019 were extracted from nationwide Neuro-Oncology Registry. Short-course...