A5054797402- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Diverticular Disease and Complications
- Diagnosis and treatment of tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Biosimilars and Bioanalytical Methods
- Systemic Lupus Erythematosus Research
- Gastrointestinal disorders and treatments
- Hepatitis C virus research
- Acute Lymphoblastic Leukemia research
- Colorectal and Anal Carcinomas
- Pregnancy and Medication Impact
- COVID-19 and healthcare impacts
- Biliary and Gastrointestinal Fistulas
- Appendicitis Diagnosis and Management
- Hepatitis B Virus Studies
- Reconstructive Facial Surgery Techniques
- Immunotherapy and Immune Responses
- HIV, TB, and STIs Epidemiology
St Vincent's Hospital
2015-2025
The University of Melbourne
2018-2025
Austin Health
2015-2023
Austin Hospital
2016-2022
Tanana Chiefs Conference
2020
Endoscopic-post-operative-recurrence [ePOR] in Crohn's disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and compare anti-tumour necrosis factor [anti-TNF] therapy vedolizumab [VDZ] ustekinumab [UST] real-world setting. A retrospective multicentre study CD-adults curative ICR on was undertaken. ePOR defined as Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD 6. Multivariable logistic regression...
Abstract Background & Aims Crohn’s perianal fistula healing rates remain low. We evaluated the efficacy of a protocolised multidisciplinary treatment strategy optimising care in adults with fistulas. Methods A new was established at single tertiary centre. The comprised three dynamic stages directed towards achieving and maintaining healing. Stage A, active disease, focused on early commencement proactive escalation biologic therapies structured surgical reviews ensuring adequate...
ABSTRACT Acute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti‐TNF alpha therapy is known be safe pregnancy, however, data surrounding outcomes ASUC limited. In this report, we present the case of pregnant patient 10 weeks' gestation successfully managed intensified accelerated infliximab for total dose 35 mg/kg during single admission. This highlights use therapeutic strategy, as part multidisciplinary approach,...
Abstract Background Fibrostenotic strictures are common in Crohn’s disease, have limited treatment options and lack validated biomarkers to predict response. Fourier-transform infra-red (FTIR) spectroscopy provides reproducible biochemical information from biospecimens using a rapid, label-free, non-destructive technique via molecular vibrations. We previously completed proof-of-concept study that identified spectral for inflammation model of colitis.1 The aim this was investigate whether...
Abstract Objective We postulated that adalimumab [ADA] drug clearance [CL] may be a more critical determinant of therapeutic outcome than ADA concentration. This was tested in Crohn’s disease [CD] patients undergoing maintenance treatment. Methods CD from four cohorts received induction and started therapy. Therapeutic outcomes consisted endoscopic remission [ER], sustained C-reactive protein [CRP] based clinical [defined as CRP levels below 3 mg/L the absence symptoms], faecal calprotectin...
Abstract Background and Aims Strictures are the most common Crohn's disease complication, but their natural history is unknown. This study aimed to characterize inflammation, predict prognosis, understand impact of drug therapy using magnetic resonance enterography (MRE). Methods Patients with a stricture diagnosed on MRE over 5‐year period were reviewed for extent clinical course, C‐reactive protein, response anti‐TNF therapy, endoscopic dilatation, hospitalization, surgery. Results 136...
Thiopurine use in inflammatory bowel disease (IBD) is limited by drug toxicity and lack of therapeutic efficacy. We assessed the utility thiopurine metabolite testing relationship between activity, dose, levels a real world setting.Patients identified from pathology databases (2007-2012) at two tertiary IBD centers were included if they had thiopurines for least four weeks. Demographics, test indication, clinical status, action taken, outcome obtained retrospective medical record review.A...
We evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic (PPF) pharmacokinetic (PK) origin impacting immune response (formation antidrug antibodies) disease control inflammatory bowel (IBD) patients treated with infliximab or adalimumab.
ABSTRACT The Crohn's Disease Exclusion Diet (CDED) with partial enteral nutrition (PEN) is an emerging treatment option for disease (CD). A 35-year-old pregnant woman presented newly diagnosed ileal CD. At 14/40 gestation, CDED + PEN was prescribed without drug therapy. Outcomes included Harvey-Bradshaw Index, weight, and bowel wall thickness/Limberg score measured on intestinal ultrasound (IUS). In this patient, achieved clinical biochemical remission, improvements IUS, gestational weight...
Objective: To evaluate the effect of Star Wars music (SWM) compared with endoscopist-selected popular (PM) on quality outcomes in colonoscopy. Design and setting: A single-centre, prospective, randomised controlled trial conducted an endoscopy suite within a quaternary-centre gastroenterology unit, Melbourne, Australia. Main outcome measures: The primary measures were procedure time, polyp detection rate (PDR) adenoma (ADR). secondary measure was adenomas per colonoscopy (APC). Results: 103...
Abstract Background Despite best standard care, sustained healing rates of Crohn’s perianal fistulas remain low. A novel coordinated multi-disciplinary care model optimising medical and surgical treatment was established with the aim to improve fistula rates. Methods prospective real-world observational study evaluated efficacy this new in adults fistulas. Patients seen through were sequentially invited participate, between March 2021 April 2022, included irrespective disease activity,...