A5006250978- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- Cancer Immunotherapy and Biomarkers
- Inflammatory Bowel Disease
- Statistical Methods and Bayesian Inference
- Microscopic Colitis
- Birth, Development, and Health
- Antibiotics Pharmacokinetics and Efficacy
- Esophageal Cancer Research and Treatment
- Antibiotic Resistance in Bacteria
- Ferroptosis and cancer prognosis
- Vaccine Coverage and Hesitancy
- Colorectal Cancer Screening and Detection
- Lymphoma Diagnosis and Treatment
- Antibiotic Use and Resistance
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- Climate Change and Health Impacts
- Neonatal Respiratory Health Research
- Influenza Virus Research Studies
- Statistical Methods in Clinical Trials
- Cancer, Lipids, and Metabolism
- COVID-19 epidemiological studies
- Immune Cell Function and Interaction
- Health, Environment, Cognitive Aging
Tel Aviv University
2018-2025
Novem (Netherlands)
2021-2024
Rabin Medical Center
2024
Harvard University
2015-2019
Sanofi (France)
2017
Bristol-Myers Squibb (Germany)
2017
Dana-Farber Cancer Institute
2017
Novartis (Germany)
2017
Boehringer Ingelheim (Australia)
2017
Pfizer (United Kingdom)
2017
Data on BNT162b2 messenger RNA (mRNA) vaccine (Pfizer-BioNTech) effectiveness and safety in pregnancy are currently lacking because pregnant women were excluded from the phase 3 trial.To assess association between receipt of mRNA risk SARS-CoV-2 infection among women.This was a retrospective cohort study within registry large state-mandated health care organization Israel. Pregnant vaccinated with first dose December 19, 2020, through February 28, 2021, 1:1 matched to unvaccinated by age,...
Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence suggests that aspirin (a widely used nonsteroidal anti-inflammatory drug) not only prolongs colorectal cancer survival, but also activate T cell-mediated antitumor immunity and synergize with immunotherapy through inhibition prostaglandin E2 production. We hypothesized survival benefit associated might be stronger carcinoma a lower CD274...
Common methods for interpreting neural models in natural language processing typically examine either their structure or behavior, but not both. We propose a methodology grounded the theory of causal mediation analysis which parts model are causally implicated its behavior. It enables us to analyze mechanisms by information flows from input output through various components, known as mediators. apply this gender bias pre-trained Transformer models. study role individual neurons and attention...
Children not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may still benefit from vaccines through protection contacts. We estimated the provided to children parental vaccination with BNT162b2 vaccine. studied households without prior infection consisting of two parents and unvaccinated children, estimating effect on risk for children. periods separately-an early period (17 January 2021 28 March 2021; Alpha variant, doses versus no vaccination) a late (11...
Background Cyst size, its growth rate, and diameter of the main pancreatic duct (MPD) are all associated with carcinoma prevalence in intraductal papillary mucinous neoplasms (IPMNs). Objective To examine above factors relation to future risk incident individuals IPMNs harbouring no high-risk stigmata. Design In a prospective longitudinal cohort, we analysed 2549 patients IPMNs. A multivariable cause-specific Cox proportional hazards regression model was built estimate HRs for carcinoma....
Abstract In epidemiology, public health and social science, mediation analysis is often undertaken to investigate the extent which effect of a risk factor on an outcome interest mediated by other covariates. A pivotal quantity in such proportion. common method for estimating it, termed “difference method”, compares estimates from models with without hypothesized mediator. However, rigorous methodology estimation statistical inference this has not previously been available. We formulated...
Expression of the immune checkpoint ligand CD274 (programmed cell death 1 1, PD-L1, from gene CD274) contributes to suppression antitumor T cell-mediated response in various tumor types. However, role PDCD1LG2 (PD-L2, CD273, PDCD1LG2) microenvironment remains unclear. We hypothesized that expression might be inversely associated with lymphocytic reactions colorectal cancer. examined by IHC 823 colon and rectal carcinoma cases within two U.S.-nationwide cohort studies categorized tumors into...
It is still of debate whether the advent biologics has been associated with a change in natural history ulcerative colitis [UC]. In this nationwide study we evaluated trends long-term outcomes all patients diagnosed UC Israel during biologic era.Data epi-IIRN cohort were retrieved from four Israeli Health Maintenance Organizations covering 98% population, and linked to Ministry prospective registry on surgeries hospitalizations. Joinpoint Regression Kaplan-Meier survival analyses used,...
Since data on predictors of complicated Crohn's disease (CD) from unselected populations are scarce, we aimed to utilize a large nationwide cohort, the epi-IIRN, explore course in children and adults with CD.
Antibiotic resistance is influenced by prior antibiotic use, but precise causal estimates are limited. This study uses penicillin allergy as an instrumental variable (IV) to estimate the effect of antibiotics on resistance. A retrospective cohort 36,351 individuals with E. coli positive urine cultures and outpatient outcomes assessed up one year post-exposure, was analyzed using data from Maccabi Healthcare Services (MHS), second-largest non-profit health fund in Israel. IV methods estimated...
ABSTRACT Studies have shown that the effect an exposure may on a disease can vary for different subtypes of same disease. However, existing approaches to estimate and compare these effects largely overlook causality. In this paper, we study smoking having colorectal cancer defined by trait known as microsatellite instability (MSI). We use principal stratification propose alternative causal estimand, Subtype-Free Average Causal Effect (SF-ACE). The SF-ACE is among those who would be free from...
Microbial resistance exhibits dependency patterns between different antibiotics, termed cross-resistance and collateral sensitivity. These differ experimental clinical settings. It is unclear whether the differences result from biological reasons or confounding, biasing results found in We set out to elucidate underlying antibiotics data, while accounting for patient characteristics previous antibiotic usage.Additive Bayesian network modelling was employed simultaneously estimate...
Data on predictors of complicated ulcerative colitis (UC) course from unselected populations cohorts are scarce. We aimed to utilize a nationwide cohort explore at diagnosis disease in children and adults with UC.
Adequate thyroid hormone availability is required for normal brain development. Studies have found associations between prenatal exposure to air pollutants and hormones in pregnant women newborns. We aimed examine of trimester-specific residential common with congenital hypothyroidism (CHT). All term infants born Israel during 2009-2015 were eligible inclusion. used data on CHT from the national neonatal screening lab Israel, spatiotemporal pollution models. multivariable logistic regression...
The effectiveness of biologics for improving long-term outcomes in patients with Crohn's disease [CD] is still controversial. In this nationwide study, we aimed to evaluate trends all CD Israel during the era.Trends were analysed using data from four Israeli health maintenance organisations, covering 98% population; joinpoint regression models used explore changes these over 2005 2019.A total 16 936 diagnosed since (2932 [17%] paediatric onset, 14 004 [83%] adult onset) 114 947 person-years...