A5042682565- Cancer, Hypoxia, and Metabolism
- Antibiotic Use and Resistance
- Estrogen and related hormone effects
- Bioinformatics and Genomic Networks
- Antibiotic Resistance in Bacteria
- Cancer, Lipids, and Metabolism
- Acute Myocardial Infarction Research
- Antibiotics Pharmacokinetics and Efficacy
- Heart Failure Treatment and Management
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Bacterial Identification and Susceptibility Testing
- Computational Drug Discovery Methods
- Obstructive Sleep Apnea Research
- Voice and Speech Disorders
- Microbial Metabolic Engineering and Bioproduction
- Pharmaceutical Practices and Patient Outcomes
- Gene Regulatory Network Analysis
- Renal Diseases and Glomerulopathies
- Patient Safety and Medication Errors
- Neuroscience of respiration and sleep
- Emergency and Acute Care Studies
- Diabetes and associated disorders
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
Tel Aviv University
2010-2024
Meir Medical Center
2019-2024
Clalit Health Services
2020
Rabin Medical Center
2010-2019
Tel Aviv Sourasky Medical Center
2017
Friedrich Schiller University Jena
2016
Charité - Universitätsmedizin Berlin
2012
VTT Technical Research Centre of Finland
2012
Michigan State University
2004
Inferring drug-drug interactions (DDIs) is an essential step in drug development and administration. Most computational inference methods focus on modeling pharmacokinetics, aiming at that result from a common metabolizing enzyme (CYP). Here, we introduce novel prediction method, INDI (INferring Drug Interactions), allowing the of both pharmacokinetic, CYP-related DDIs (along with their associated CYPs) pharmacodynamic, non-CYP ones. On cross validation, it obtains high specificity...
Type-II MI is defined as myocardial infarction (MI) secondary to ischemia due either increased oxygen demand or decreased supply. This categorization has been used for the last five years, yet, little known about patient characteristics and clinical outcomes. In current work we assessed epidemiology, causes, management outcomes of type II patients.A comparative analysis was performed between patients with type-I type-II who participated in two prospective national Acute Coronary Syndrome...
Abstract Aberrant metabolism is a hallmark of cancer, but whole metabolomic flux measurements remain scarce. To bridge this gap, we developed novel metabolic phenotypic analysis (MPA) method that infers phenotypes based on the integration transcriptomics or proteomics data within human genome-scale model. MPA was applied to conduct first study breast cancer gene expression large cohort clinical samples. The modeling correctly predicted cell lines' growth rates, tumor lipid levels, and amino...
Utilizing molecular data to derive functional physiological models tailored for specific cancer cells can facilitate the use of individually therapies. To this end we present an approach termed PRIME generating cell-specific genome-scale metabolic (GSMMs) based on and phenotypic data. We build >280 normal cell-lines that successfully predict phenotypes in individual manner. utilize set drug targets selectively inhibit cancerous but not cell proliferation. The top predicted target, MLYCD, is...
Infections are one of the most common causes for hospitalization patients with heart failure (HF). Yet, little is known regarding prevalence and predictors different types acute infections as well their impact on outcome among this growing population.We identified all aged 50 or older a major diagnosis HF at least echocardiography examination who had been hospitalized over 10-year period (January 2000 December 2009). Infection-associated admissions were according to discharge diagnoses....
Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge electronic health records (EHRs). The emergence of large EHR offers opportunity to integrate population information actively into these tools. Here, we assess ability corpus predict individual discharge diagnoses. We present method that exploits similarities between patients along multiple...
Computerized decision support systems are becoming increasingly prevalent with advances in data collection and machine learning (ML) algorithms. However, they scarcely used for empiric antibiotic therapy. Here, we predict the resistance profiles of bacterial infections hospitalized patients using ML algorithms applied to patients' electronic medical records (EMRs).The included results cultures from patients, alongside their EMRs. Five antibiotics were examined: ceftazidime (n = 2942),...
High antibiotic resistance frequencies have become a major public health issue. The decrease in new antibiotics' production, combined with increasing of multi-drug resistant (MDR) bacteria, cause substantial limitations treatment options for some bacterial infections. To diminish overall resistance, and especially the occurrence bacteria that are to all antibiotics, certain drugs deliberately scarcely used—mainly when other exhausted. We use mathematical model explore efficiency such...
A standardized agar dilution susceptibility testing method was developed for Campylobacter that consisted of on Mueller–Hinton medium supplemented with 5% defibrinated sheep blood in an atmosphere 10% CO2, O2, and 85% N2. jejuni ATCC 33560 identified as a quality-control (QC) strain. Minimal inhibitory concentration (MIC) QC ranges were determined two incubation time/temperature combinations: 36°C 48 hr 42°C 24 hr. Quality-control ciprofloxacin, doxycycline, erythromycin, gentamicin,...
Microbial resistance exhibits dependency patterns between different antibiotics, termed cross-resistance and collateral sensitivity. These differ experimental clinical settings. It is unclear whether the differences result from biological reasons or confounding, biasing results found in We set out to elucidate underlying antibiotics data, while accounting for patient characteristics previous antibiotic usage.Additive Bayesian network modelling was employed simultaneously estimate...
<h3>Objective:</h3> To assess and compare anatomical changes in the velopharynx produced by conventional uvulopalatopharyngoplasty laser-assisted uvulopalatoplasty. <h3>Design:</h3> A before-after trial of patients who underwent or palatal surgical procedures. <h3>Patients Interventions:</h3> total 174 (157 men 17 women; age range, 22-71 years; mean age, 48 years) were suffering from heavy snoring (n=16) obstructive sleep apnea. The first 100 consecutive uvulopalatopharyngoplasty, remaining...
Abstract: Neurolymphomatosis is a rare manifestation of progressive non‐Hodgkin's lymphoma. A 44‐yr‐old man with diffuse large B‐cell lymphoma presented unilateral peripheral sensorimotor neuropathy after the 7th cycle R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) therapy. No pathology in nervous system was evident by computerized tomography (CT), magnetic resonance imaging (MRI) head, spinal axis plexuses repeated analysis cerebrospinal fluid. However, hybrid...
Anal fissure is a common and painful disorder. Its relation to hypertonic anal sphincter controversial. The most surgical treatment of chronic lateral internal sphincterotomy.The aim this study was evaluate long-term manometric results healing following sphincterotomy.Between 2000 2003, 50 patients with were included in underwent sphincterotomy; 12 healthy served as controls. All evaluation using 6-channel perfusion catheter. examined 1 month before surgery 1, 3, 6, months surgery. control...
We aimed to assess associations of physician's work overload, successive shifts, and experience with physicians' risk err.This large-scale study included physicians who prescribed at least 100 systemic medications Sheba Medical Center during 2012-2017 in all acute care departments, excluding intensive units. Presumed medication errors were flagged by a high-accuracy computerized decision support system that uses machine-learning algorithms detect potential prescription errors. Physicians'...
To assess the subjective and objective medium- to long-term results of laser-assisted uvulopalatoplasty for snoring.A nonrandomized, prospective, before-after trial.Fourteen patients underwent surgery; 2 surgical techniques, which differ with respect mode midline palatal vaporization, were used.Subjective analysis included a preoperative postoperative evaluations state snoring: 4 weeks 10.1 +/- 7.9 months (mean SD) after completion last laser treatment. In addition, score on 5 other...
To assess medium- to long-term subjective and objective results of laser-assisted uvulopalatoplasty (LAUP) for patients with obstructive sleep apnea.A nonrandomized prospective before-after trial.Twenty-six underwent LAUP by means vertical trenches along either side the uvula reduction uvula.Subjective analysis included a preoperative 2 postoperative evaluations state snoring: 4 weeks mean +/- SD 12.3 9.1 months after completion treatment. In addition, score on 5 other sleep-related symptoms...
Detection of Phosphodiesterase Type 5 (PDE-5) inhibitors and their analogues in "100% natural" or "herbal" supplements have been described numerous reports. However, few reports published relation to actual harm caused by counterfeit erectile dysfunction herbal supplements. We describe a case 65-year old male admitted tertiary hospital with acute liver toxicity, possibly induced adulterated "Chinese herbal" supplement "Tiger King" for sexual enhancement. Chemical analysis the tablets...