A5079171526- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Pharmaceutical studies and practices
- Maternal and Perinatal Health Interventions
- Pregnancy and Medication Impact
- Biosimilars and Bioanalytical Methods
- Eosinophilic Esophagitis
- Acute Lymphoblastic Leukemia research
- Breastfeeding Practices and Influences
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Maternal and fetal healthcare
- Primary Care and Health Outcomes
- Sex work and related issues
- Diabetes Management and Education
- Child Nutrition and Water Access
- Acute Ischemic Stroke Management
- Adolescent Sexual and Reproductive Health
- Obesity and Health Practices
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- Liver Diseases and Immunity
- Reproductive Health and Contraception
Clalit Health Services
2021-2025
Hebrew University of Jerusalem
2019-2021
The Ohio State University
2016-2017
Nationwide Children's Hospital
2017
In a nationwide cohort, we aimed to compare the durability of infliximab and adalimumab as first biologic treatment in children with Crohn's disease (CD), stratified combotherapy or monotherapy.
It is still of debate whether the advent biologics has been associated with a change in natural history ulcerative colitis [UC]. In this nationwide study we evaluated trends long-term outcomes all patients diagnosed UC Israel during biologic era.Data epi-IIRN cohort were retrieved from four Israeli Health Maintenance Organizations covering 98% population, and linked to Ministry prospective registry on surgeries hospitalizations. Joinpoint Regression Kaplan-Meier survival analyses used,...
Since data on predictors of complicated Crohn's disease (CD) from unselected populations are scarce, we aimed to utilize a large nationwide cohort, the epi-IIRN, explore course in children and adults with CD.
Summary Background Both corticosteroids and exclusive enteral nutrition (EEN) have been used as induction therapy in children with Crohn's disease (CD). Aim To compare a nationwide study the long‐term outcomes of CD receiving either EEN or therapy. Methods We retrieved data all diagnosed (2005–2020) from epi‐IIRN cohort covering 98% Israeli population. The primary outcome was time to complicated course (i.e., surgery, steroid‐dependency, at least 2 biologic class). Patients were matched...
Abstract Background Fatigue is a common and burdensome symptom experienced by patients with Inflammatory Bowel Diseases (IBD), yet it remains under-recognised understudied. This study aimed to assess the prevalence incidence of recorded fatigue in first nationwide cohort investigation this topic. Methods We utilised epi-IIRN cohort, encompassing all IBD Israel across four Health Maintenance Organisations (HMOs), covering 98% population. These were matched non-IBD controls (by birth year,...
Abstract Background Systematic interpretation and quantification of inflammation stenosis in inflammatory Bowel Disease (IBD) from radiology reports CT MR enterography exams are challenging due to their unstructured nature, often leading variability reduced reproducibility. This study leverages data the epi-IIRN nationwide cohort develop evaluate machine-learning-based scores for derived these reports. Methods We identified IBD-diagnosed patients within cohort, which encompasses Israel’s...
Abstract Background Data regarding burden of depression and anxiety in pediatric-onset inflammatory bowel diseases (PIBD) are limited. We aimed to study the prevalence a nationwide cohort PIBD Methods were retrieved from epi-IIRN, 4 Israeli Health Maintenance Organizations covering 98% population 2005. matched children non-IBD controls for calculating time depression/anxiety. Patients with depression/anxiety prior IBD diagnosis excluded. Poor disease course (PDC) was defined as IBD-related...
Abstract Background In this nationwide study, we aimed to explore health care services utilization, medical management, and disease outcomes of inflammatory bowel diseases (IBD) across the two major ethnic groups in Israel. Methods We utilized a cohort including all patients diagnosed with IBD Israel since 2005. The primary outcome was steroid dependency, secondary use biologics, time surgery, hospitalizations. Outcomes were controlled for possible inherent differences course phenotype....
Few postpartum women use effective contraception and those who less methods have increased rates of unintended pregnancy. Little is known about intentions among breastfeeding women. Our objectives were to measure the extent prenatal contraceptive counseling, assess intentions, identify correlates both planning breastfeed.
Milk expression has become common, but little is known about women's intentions and motivations for pumping. Our objectives were to measure, among newly postpartum women, related breast milk feeding pumping, reasons intending pump, timing of pumping initiation.We conducted a cross-sectional study at large university hospital in 2015 using convenience sample 100 women before their discharge following delivery, who intended feed infant least 6 months.All participants planned baby the breast....
Abstract Background In this nationwide study, our objective was to compare the durability of first-line biologics in ulcerative colitis (UC), categorized into monotherapy and combotherapy with immunomodulators. Methods We utilized data from epi-IIRN cohort 2005 2020. Durability defined as consistent treatment without surgery. Comparisons were based on stringent propensity score-matching. Results included 15 111 patients UC, whom 2322 (15%) received biologics, a median follow-up 7.0 years...
Data on predictors of complicated ulcerative colitis (UC) course from unselected populations cohorts are scarce. We aimed to utilize a nationwide cohort explore at diagnosis disease in children and adults with UC.
Abstract Background In this nationwide study we aimed to compare the durability of first initiated biologic in Crohn’s disease [CD], stratified by monotherapy and combotherapy. Methods We used data from epi-IIRN cohort, which includes 98% Israeli inflammatory bowel population [2005–2020]. Durability was defined as consistent treatment without surgery or added medications [except for combination therapy with thiopurines methotrexate]. All comparisons were based on stringent propensity-score...
Introduction Few studies have compared midwife‐led and physician‐led care in the United States. Our objective was to compare frequency of birth interventions maternal neonatal outcomes between women who received prenatal from a midwife those physician, among were low risk when they initiated care. Methods We performed retrospective cohort study giving at large public hospital had least one visit before 20 weeks’ gestation years 2012 through 2015. classified according provider type (midwife...
The effectiveness of biologics for improving long-term outcomes in patients with Crohn's disease [CD] is still controversial. In this nationwide study, we aimed to evaluate trends all CD Israel during the era.Trends were analysed using data from four Israeli health maintenance organisations, covering 98% population; joinpoint regression models used explore changes these over 2005 2019.A total 16 936 diagnosed since (2932 [17%] paediatric onset, 14 004 [83%] adult onset) 114 947 person-years...
Anti-drug antibodies (ADA) to anti-tumour necrosis factor (anti-TNF) therapy drive treatment loss of response. An association between intestinal microbial composition and response anti-TNF was noted. We therefore aimed assess the implications antibiotic treatments on ADA formation in patients with inflammatory bowel disease (IBD).We analysed data from epi-IIRN (epidemiology group Israeli IBD research nucleus), a nationwide registry all Israel. included treated who had available levels....
The growing use of GLP-1 analogs for type 2 diabetes mellitus (DM2) and obesity necessitates studies about their in patients with inflammatory bowel diseases (IBD).
Abstract Background Data regarding patients with ulcerative colitis (UC) not receiving maintenance treatment are scarce. In this nationwide study, we aimed to explore the frequency and long-term outcomes of untreated UC vs treated patients. Methods We retrieved data from Israel’s Health Maintenance Organizations, covering 98% population. No (NMT) was defined as lack during period 3 6 months diagnosis, allowing at most for induction treatment. Results A total 15 111 have been diagnosed since...
Thiopurines and methotrexate have long been used to maintain remission in Crohn's disease [CD]. In this nationwide study, we aimed compare the effectiveness safety of these drugs CD.We data from epi-IIRN cohort, including all patients with CD diagnosed Israel. Outcomes were compared by propensity-score matching included therapeutic failure, hospitalisations, surgeries, steroid dependency, adverse events.Of 19264 since 2005, 3885 [20%] ever received thiopurines as monotherapy 553 [2.9%]...
For the many millions of migrants, mobility creates vulnerabilities and elevates risk for sexually transmitted infections (STIs). We document, among Tanzanian agricultural plantation residents, migrant characteristics test associations between status prevalent STI (HSV-2, syphilis, HIV). From 623 resident participants, we limit this analysis to participants about whom know migration (migrants n = 242, non-migrants 291). collected behavioral data via audio-computer assisted self-interview...
Little is known about how in-hospital supplementation with water, infant formula, or sugar water affects the relationship between breastfeeding intentions and duration, whether this differs by gestational diabetes mellitus (GDM) history. Our study objectives were to assess associations GDM exclusive intentions, hospital supplementation, including mediates association duration.Using data from Infant Feeding Practices Study II (2005-2007), we included women (n = 160) without prepregnancy (no...
Abstract Background Both adult and pediatric patients with inflammatory bowel disease (IBD) are at risk of osteopenia osteoporosis, nevertheless, whether IBD subjected to a higher for bone fractures is debated. Thus, we aimed assess the fractures, osteoporosis in vs non-IBD patients, using epi-Israeli Research Nucleus (IIRN) data. Methods Data matched controls (approximately 3 per case) were retrieved from epi-IIRN cohort (January 2005- June 2020) that maintain data on all four Israeli HMOs....