A5101629539- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Multiple and Secondary Primary Cancers
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Growth Hormone and Insulin-like Growth Factors
- Management of metastatic bone disease
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Lymphoma Diagnosis and Treatment
Lanzhou University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Harvard University
2017-2022
Brigham and Women's Hospital
2020-2022
Second Affiliated Hospital of Nanjing Medical University
2022
Dana-Farber Cancer Institute
2017-2020
Anlotinib is a novel multi-target tyrosine kinase inhibitor that designed to primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. We aimed evaluate the safety, pharmacokinetics, antitumor activity of anlotinib in patients with advanced refractory solid tumors. (5–16 mg) was orally administered tumor once day on two schedules: (1) four consecutive weeks (4/0) or (2) 2-week on/1-week off (2/1). Pharmacokinetic sampling performed all patients. Twenty-one were further enrolled an...
Abstract Background It remains unclear whether addition of docetaxel to the combination a platinum and fluoropyrimidine could provide more clinical benefits than doublet chemotherapies in perioperative treatment for locally advanced gastric/gastro-esophageal junction (LAG/GEJ) cancer Asia. In this randomized, phase 2 study, we assessed efficacy safety plus oxaliplatin S-1 (DOS) versus (SOX) LAG/GEJ adenocarcinoma patients. Methods Patients with cT3–4 N any M0 G/GEJ were randomized (1:1)...
Abstract Background Histological lymphocytic reaction is regarded as an independent prognostic marker in colorectal cancer. Considering the lack of adequate statistical power, adjustment for selection bias and comprehensive tumour molecular data most previous studies, we investigated strengths associations carcinoma by utilising integrative database two prospective cohort studies. Methods We examined Crohn’s-like reaction, intratumoural periglandular peritumoural tumour-infiltrating...
// Mancang Gu 1, 2 , Reiko Nishihara 3, 4, 5, 6 Yang Chen 7 Wanwan Li 1 Yan Shi Yohei Masugi Tsuyoshi Hamada Keisuke Kosumi Liu 3 Annacarolina da Silva Jonathan A. Nowak Tyler Twombly Chunxia Du Hideo Koh Wenbin Jeffrey Meyerhardt 8 Brian M. Wolpin Marios Giannakis Andrew J. Aguirre Adam Bass 8, 9, 10 David Drew 11, 12 T. Chan Charles S. Fuchs 13, 14, 15, * Zhi Rong Qian 6, and Shuji Ogino Department of Oncologic Pathology, Dana-Farber Cancer Institute Harvard Medical School, Boston, MA, USA...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with low 5-year survival rate. Treatment options for PDAC patients are limited. Recent studies have shown promising results MRTX1133, KRAS G12D inhibitor that demonstrated potent antitumor activity in various types of tumors mutation. Resistance to inhibitors frequently occurred and one the main reasons treatment failure. Understanding resistance mechanisms novel crucial ensure sustained durable remissions....
Abstract Background: Insulin-like growth factor-1 receptor (IGF1R) signaling is important in pancreatic ductal adenocarcinoma (PDAC) biology, but little known regarding IGF1R expression and patient characteristics outcomes. Methods: In 365 patients with resected PDAC, we evaluated protein using IHC on whole-slide sections genomic status next-generation sequencing. Associations of expression, measured by H-scores incorporating staining intensity proportion positive tumor cells, disease-free...
BACKGROUND Whether patients with diffuse gastric cancer, which is insensitive to chemotherapy, can benefit from neoadjuvant or adjuvant chemotherapy has long been controversial. AIM To investigate whether perioperative improve survival of locally advanced cancer. METHODS A total 2684 cancer 18 population-based registries in the United States were analyzed. RESULTS Compared surgery alone, improved prognosis Before stabilized inverse probability treatment weighting (IPTW), median overall (OS)...
Evidence suggests that high-level physical activity may potentially reduce cancer mortality through its immune enhancement effect. We therefore hypothesized survival benefits associated with might be stronger in colorectal carcinomas lower reaction at diagnosis.Using molecular pathological epidemiology databases of 470 colon and rectal carcinoma cases the Nurses' Health Study Professionals Follow-up Study, we assessed prognostic association postdiagnosis strata densities CD3+ cells, CD8+...
Vascular endothelial growth facto receptor-tyrosine kinase inhibitors (VEGFR-TKIs) are widely used for metastatic renal cell carcinoma (mRCC). The aim of this study was to investigate the association between response VEGFR-TKIs and hyperlipidemia hypothyroidism.Clinical data on 155 patients with mRCC treated at Cancer Hospital Chinese Academy Medical Sciences from 2006 2014 were retrospectively analyzed. All received first-line TKI therapy. Survival analysis performed a significance level...
Oxaliplatin induces splenomegaly, which can cause blood sequestration and relevant cytopenia, leading to further dose reductions schedule modifications of chemotherapy. Here, we aimed explore the changes spleen volume induced by oxaliplatin as well its impact on parameters anti-neoplastic treatment in patients with colon cancer.We conducted a retrospective analysis resectable stage II-IV cancer who were treated capecitabine at our institution from January 2016 December 2017. Laboratory tests...
The exact clinical significance of EGFR mutation status in NSCLC at the time initial diagnosis remains disputable.The gene expression module for chemotherapy outcome prediction needs to be developed.We analyzed 56 patients with received either (n=20) or without EGFR-TKIs (n=36) between 2008 and 2012 China.EGFR test profiling were performed samples obtained before medication treatment by liquidchip platform.Significant association (P = 0.028) was seen first-line outcomes, which even can found...
e13586 Background: To establish the safety, pharmacokinetics, recommended dose, and antitumor activity of anlotinib, a novel oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors. Methods: Anlotinib was given orally once day for consecutive 4 weeks or 2 on/1 week off. In dose group, 5mg/d (n = 4) 10mg/d explored; off 3), 16mg/d 12mg/d 21) explored. Human plasma urine samples were analyzed by liquid chromatography-mass spectrometry. Results:...
Liver cysts in infants are uncommon. With modern diagnostic imaging, we can achieve an early diagnosis of congenital hepatic cysts. Our purpose was to investigate the clinical features, surgical treatment methods and prognosis with Herein, report a case series cysts.Eleven were retrospectively analysed. Ten them had simple cysts, girl large mass diagnosed solitary intrahepatic biliary cyst accompanied by choledochal cyst. Among ten eight two multiple. A total 87.5% (7 8) detected before...
88 Background: Splenic enlargement has been reported in patients treated with oxaliplatin. However, the characteristics of oxaliplatin-induced splenomegaly were not well studied. Here we evaluated change splenic volume and its clinical significance by oxaliplatin-based regimen. Methods: Patients stage II-IV primary colon cancer oxaliplatin capecitabine China National Cancer Center from January 2016 to December 2017 screened for this retrospective study. Those complete laboratory tests...
Objective To evaluate the efficacy and safety of sorafenib in treatment Chi-nese patients with metastatic renal cell carcinoma. Methods This muhicenter phase Ⅱ clinical trial was performed from May 2006 to December 2006. Sixty-two carci-noma not suitable for curative were enrolled. All received oral as single a-gent at dose 400 mg twice a day until disease progression or intolerable toxicities occurred. Re-salts Partial responses recorded best response 11 patients, while complete remission...
Gastric adenocarcinoma (GA) is a heterogeneous tumor, and the accurate classification of GA important. Previous classifications are based on molecular analysis have not focused with primitive enterocyte phenotype (GAPEP), unique subtype poor prognosis frequent liver metastases. New substituted (SM) immunohistochemistry (IHC) needed.