A5100419428- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ion Channels and Receptors
- Circular RNAs in diseases
- Electrocatalysts for Energy Conversion
- Asthma and respiratory diseases
- Ubiquitin and proteasome pathways
- Respiratory and Cough-Related Research
- Catalytic Processes in Materials Science
- Supercapacitor Materials and Fabrication
- Advanced Photocatalysis Techniques
- Cancer-related gene regulation
- RNA modifications and cancer
- Advancements in Solid Oxide Fuel Cells
- Platelet Disorders and Treatments
- Plant Reproductive Biology
- CRISPR and Genetic Engineering
- Retinoids in leukemia and cellular processes
- RNA Research and Splicing
- Complement system in diseases
- CO2 Reduction Techniques and Catalysts
- Plant Molecular Biology Research
- Natural product bioactivities and synthesis
- Catalysis and Oxidation Reactions
Lanzhou University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Beihai People's Hospital
2025
Eye & ENT Hospital of Fudan University
2025
Fudan University
2025
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2022-2024
Zhengzhou University
2013-2024
ShanghaiTech University
2024
Beijing Foreign Studies University
2024
For the 2D metal-free carbon catalysts, atomic coplanar architecture enables a large number of p
Abstract Accumulating data have suggested exosome‐delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR‐6803‐5p on development prognosis colorectal (CRC). Levels serum were determined by microarray analysis verified quantitative real‐time PCR (qRT‐PCR). Outcomes overall survival (OS) disease‐free (DFS) CRC patients estimated Kaplan‐Meier analysis. We used cox regression to investigate association...
Abstract The goal of global carbon peak and neutrality gives an impetus to the utilization clean energy (e.g., fuel cell) dioxide (CO 2 ) at a large scale, where oxygen reduction reaction (ORR) CO RR) are key reactions via sustainable system, respectively. As main precursor for fabricating affordable carbon‐based electrocatalysts with uniformly dispersed active centers tailorable performances ORR RR, metal organic frameworks (MOFs) have captured surge interest in recent years. Despite...
Breast cancer (BC) is a common malignant tumor in females. The challenge treating BC overcoming chemoresistance. Exosome-mediated transfer of miRNAs molecule-shuttle intercellular communication. Thus, we aimed to investigate whether exosomal miRNA-205 could affect chemoresistance and tumorigenesis recipient cells elucidate the underlying mechanism vivo vitro. Microarray qRT-PCR assays demonstrated that was upregulated tamoxifen resistance MCF-7/TAMR-1 (M/T) M/T cell-derived exosomes...
Daqu is a traditional Chinese baijiu starter. To investigate the composition of microbial community daqu starters, high-throughput sequencing (HTS) combined with culture-dependent method was used to analyze fungal diversity thirty starters made at three temperatures (low-, medium- and high-temperature). In study, we isolated 420 isolates strains through plate culture method. Saccharomyces cerevisiae, Wickerhamomyces anomalus Saccharomycopsis fibuligera were most common yeasts encountered in...
Magnetic core–shell structures provide abundant opportunities for the construction of multifunctional composites. In this article, magnetic core–shells were fabricated with Co nanoparticles (NPs) as cores and g-C3N4 shells. fabrication process, Co@g-C3N4 anchored onto rGO nanosheets to form a Co@g-C3N4-rGO composite (CNG-I). For hydrogen generation from hydrolysis NaBH4 or NH3BH3, NP act catalytic active sites. The shells protect NPs aggregating growing. connection between was strengthened...
Abstract Background Postmenopausal osteoporosis (PMO) that results from estrogen withdrawal is the most common primary among older women. However, little known about mechanism of PMO, and effective treatment PMO limited. Methods We used real-time polymerase chain reaction (qPCR), Western blotting, RNA pull down to investigate relationship between miR-186 MOB Kinase Activator 1A (Mob1). Also, we investigated effect exosome in osteogenesis using alkaline phosphatase (ALP) staining. And...
Exosome-encapsulated microRNAs have been recognized as novel and stable biomarkers for cancer. However, little is known about the role of exosomal in colon In present study, we investigated expression serous microRNA-638 (miR-638) its prognostic effect patients with Serous samples were assayed by quantitative real-time PCR. Kaplan-Meier analysis was adopted to determine overall survival (OS) disease-free (DFS) cancer patients. Cox regression applied assess potential association between...
Human mesenchymal stem cells (hMSCs) possess the potential to differentiate into endothelial (EC). DNA methylation plays an important role in cell differentiation during development. However, of methyltransferases Dnmt1 and Dnmt3a specific arterial hMSCs is not clear. Here, we show that CpG islands promoter regions EC specification marker genes were highly methylated based on bisulfite genomic sequencing. Treatment with DNMT inhibitor 5-aza-dc induced reactivation by promoting demethylation...
Activated neutrophil-derived exosomes reportedly contribute to the proliferation of airway smooth muscle cells (ASMCs), thereby aggravating wall remodeling during asthma; however, specific mechanism remains unclear. Lipopolysaccharide (LPS)-EXO and si-CRNDE-EXO were extracted from media human neutrophils treated with LPS + si-CRNDE (a siRNA targets long non-coding RNA CRNDE), respectively. Human ASMCs co-cultured LPS-EXO or si-CRNDE-EXO, cell viability, migration measured. The interplay...
Background Nonunion of femoral neck fractures following internal fixation presents a significant challenge, particularly in young patients. This study evaluated the efficacy valgus osteotomy treating fracture nonunion after failed adults. Methods A retrospective analysis was conducted including total 23 male patients with mean age 32.9 years, who underwent for nonunion. The procedure involved lateral closing wedge at subtrochanteric level, followed by dynamic hip screw (DHS). postoperative...
The increasing uncertainties and model computational complexity of large-scale power system state estimation have led to the emergence a class multi-source metrology devices provide vector data for grid improve observability. Considering difficult problem optimizing configuration measurement due large number nodes, distributed optimal framework is proposed. First, based on concepts sensitivity electrical distance, distance derived partitioned using improved community partitioning principle;...
Purpose To investigate the genetic characteristics of four Chinese families affected by keratoconus (KC). Methods In KC, medical records, clinical observations, and blood samples were collected from all individuals. One hundred subjects without KC served as healthy controls. All controls in underwent whole exome sequencing their genomic DNA polymerase chain reaction to confirm variants. variants analyzed using online software; silico predictions three-dimensional protein structures...
Tissue resident stem cells are believed to exist in every organ, and their identification is commonly done using a combination of immunostaining for putative cell markers label-retaining (LRC) strategy. In this study, we employed these approaches identify potential the penis. Newborn rats were intraperitoneally injected with thymidine analog, 5-ethynyl-2-deoxyuridine (EdU), penis was harvested at 7 h, 3 days, 1 week, 4 weeks. It processed EdU stains immunofluorescence staining A2B5, PCNA,...
Hyperplasia of airway smooth muscle cells (ASMC) is a major contributor to remodeling in asthma. Transient receptor potential vanilloid 1 (TRPV1) an important channel mediate Ca(2+) influx. This study explores the expression TRPV1 and its effect on proliferation apoptosis rat ASMC, order find new target treat asthma.Rats were sensitized challenged with ovalbumin replicate asthmatic models. Proliferating cell nuclear antigen (PCNA) was detected by immunohistochemistry. Reverse...
Cancer-associated fibroblasts (CAFs) are continuously activated and one of the most important cellular components tumor matrix. The role CAFs in microenvironment has been widely recognized. However, underlying molecular mechanism by which promote characteristics breast cancer (BC) remains poorly understood. aim present study was to investigate potential mechanisms possible pathways collagen triple helix repeat containing-1 (CTHRC1) epithelial-mesenchymal transition (EMT) BC cells. level...
Abstract Background Over-proliferation of airway smooth muscle cell (ASMC) is one the important contributors to remodeling in asthma. The aim this study was investigate effect Shenmai injection (SMI) on proliferation rat ASMC Methods Rats were randomly divided into three groups: control group, asthma and SMI treatment group. Reverse transcription-polymerase chain reaction (RT-PCR) immunocytochemistry staining used detect mRNA protein expression transient receptor potential vanilloid 1...
Abstract For the 2D metal‐free carbon catalysts, atomic coplanar architecture enables a large number of p z orbitals to overlap laterally, thus forming π‐electron delocalization, and delocalization degree central atom dominates catalytic activity. Herein, designing sulfur‐doped defect‐rich graphitic nitride (S‐Nv‐C 3 N 4 ) materials as model, we propose strategy promote localized electron polarization by enhancing ferromagnetism ultra‐thin nanosheets. The introduction sulfur (S) further...