A5069114352- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Renin-Angiotensin System Studies
- Acute Kidney Injury Research
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Cholinesterase and Neurodegenerative Diseases
- Advanced Glycation End Products research
- Calpain Protease Function and Regulation
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Traditional Chinese Medicine Analysis
- Hydrogen's biological and therapeutic effects
- COVID-19 diagnosis using AI
- Renal and Vascular Pathologies
- Metabolism, Diabetes, and Cancer
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
Children's Hospital of Zhejiang University
2018-2024
Zhejiang University
2014-2022
The Seventh Affiliated Hospital of Sun Yat-sen University
2021
Shanghai Changzheng Hospital
2013-2021
Humboldt-Universität zu Berlin
2019-2021
Charité - Universitätsmedizin Berlin
2018-2021
Freie Universität Berlin
2020-2021
First Affiliated Hospital Zhejiang University
2018-2021
Sun Yat-sen University
2021
Guangzhou Medical University
2018-2020
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity atherosclerosis. We test, whether augments angiotensin II (Ang II)-induced vasoconstriction hence promotes Ang II-induced hypertension. Plasma levels were indeed elevated hypertensive patients, thus potential pathways which mediates these effects explored. (400...
Fenofibrate, a peroxisome proliferator-activated receptors α (PPARα) agonist, reduces vascular complications of diabetic patients but its protective mechanisms are not fully understood. Here we tested the hypothesis that fenofibrate improves endothelial dysfunction by balancing endothelium-dependent relaxation and contractility aorta in diabetes mellitus (DM). In streptozotocin-induced mice, eight weeks treatment (100 mg/Kg/d) improved endothelium dependent macro- microvessels, increased...
Abstract We investigated the fate of proliferating cells in adult monkey brain after global ischemia. used thymidine analogue bromodeoxyuridine (BrdU) to label S‐phase and their progeny Japanese macaques subjected cerebral ischemia for 20 min or a sham operation. Subsequently, newly generated were identified by BrdU immunohistochemistry, immunophenotype was determined quantitatively, using specific markers. The ischemic insult significantly increased number hippocampus temporal neocortex,...
Background: To provide tacrolimus is first-line treatment after liver and kidney transplantation. However, hypertension nephrotoxicity are common side effects that limit its use. Although tacrolimus-related well known, the underlying mechanisms not. Here, we test whether tacrolimus-induced involves RhoA (Ras homolog family member A)/ROCK (Rho-associated protein kinase) pathway in male C57Bl/6 mice. methods: Intra-arterial blood pressure was measured under anesthesia. The reactivity of renal...
Acute kidney injury (AKI) is a serious condition without efficient therapeutic options. Recent studies have indicated that recombinant human disintegrin and metalloprotease with thrombospondin motifs 13 (rhADAMTS13) provides protection against inflammation. Therefore, we hypothesized ADAMTS13 might protect AKI by reducing Bilateral renal ischemia-reperfusion (I/R) was used as models in this study. Prophylactic infusion of rhADAMTS13 employed to investigate potential mechanisms protection....
The objective of this study was to the role hydrogen-rich saline (HRS) on acute hepatic injury (AHI) in necrotizing pancreatitis (ANP).Rats were used for and an ANP model induced by injecting 5% sodium taurocholate into biliary-pancreatic duct. Experiments performed 3 groups: sham, ANP, + HRS (HRS). Animals killed at 3, 12, 24 hours after operation, then blood tissue samples harvested. Various physiological, histological, cellular molecular parameters analyzed.Analyses serum, lipase, alanine...
Abstract Aims Acute kidney injury (AKI), a major health burden, lacks effective therapy. Anti‐inflammatory actions of disintegrin and metalloproteinase with thrombospondin type 1 motif member 13 (ADAMTS13) may provide new treatment option for AKI. Along inflammation, oxidative stress is critical AKI development, yet the impact ADAMTS13 on in remains to be fully elucidated. Methods We assess recombinant human (rhADAMTS13) murine ischaemia/reperfusion (IR) model. Antioxidant stress‐enzyme...
A myokine secreted by skeletal muscles during exercise called irisin mitigates ischemia-reperfusion (I/R) injury in epithelial cells of various organs limiting damage to mitochondria. We test whether may preserve the mitochondrial integrity and function renal tubular protect against ischemia-reperfusion-induced acute kidney (AKI).
Acute kidney injury (AKI) causes multiple organ dysfunction. Here, we identify a possible mechanism that can drive brain vessel after AKI. We induced 30-minute bilateral renal ischemia-reperfusion in C57Bl/6 mice and isolated microvessels macrovessels 24 hours or 1 week later to test their responses vasoconstrictors found AKI vessels were sensitized Ang II (angiotensin II). Upregulation of FGF2 (fibroblast growth factor 2) FGFBP1 (FGF binding protein 1) expression both serum tissue suggested...
Reduced A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif member 13 (ADAMTS13) levels are observed in kidney disease. We test whether recombinant human ADAMTS13 (rhADAMTS13) mitigates renal injury chronic disease (CKD) and the potential mechanisms.CKD was established 3 months after ischaemia/reperfusion (IR). von Willebrand factor (vWF) levels, function morphological changes were analysed. Afferent arteriolar responses to angiotensin II (Ang II) acetylcholine (ACh)...
The aim of the study was to investigate influence hyperphosphorylation tau induced by okadaic acid on expression nicotinic acetylcholine receptors and neurotoxicity β-amyloid peptide. Primary cultures neurons isolated from hippocampus brains neonatal rats were exposed or/and Aβ1-42 Tau phosphorylated at Ser404 Ser202, protein expressions α7, α4 α3 nAChR subunits quantified Western blotting, their corresponding mRNAs real-time PCR. Superoxide dismutase activity assayed biochemically...
Sodium bicarbonate has long been used to treat chronic kidney disease. It demonstrated slow the decline in glomerular filtration rate disease patient; however, mechanisms are not completely understood. We hypothesized that NaHCO3 dilates afferent arterioles (Af-Art) by stimulating nitric oxide (NO) release mediated Na+/HCO3- cotransporter (NBC) contributing elevation rate. Isolated microperfused mouse renal Af-Art, preconstricted with norepinephrine (1 µmol/L), dilated 45±2% (n=6, P<0.05)...
To investigate the clinical value of urine interleukin-18 (IL-8), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for early diagnosis acute (AKI) in patients with ureteroscopic lithotripsy (URL) related urosepsis.A retrospective study was carried out 157 urosepsis after URL. The were divided into AKI group non-AKI according to Kidigo guideline IL-8, NGAL KIM-1 levels detected by enzyme-linked immunosorbent assay at 0, 4, 12, 24 48 h surgery. Receiver...
Previously, in monkeys undergoing 20 min whole brain ischemia we demonstrated that the activated calpain-induced lysosomal disruption with resultant leakage of cathepsins B and L, causes neuronal death cornu Ammonis (CA) 1 sector on day 5. Selective cathepsin inhibitors significantly protected ischemic CA1 neurons from delayed necrosis. Recently, pyridoxal phosphate (PLP) (hydrochloride) (PL) were to inhibit L vitro, because active aldehyde at position 4 pyridine ring has an affinity for...
In patients with renal disease, high serum phosphate shows a relationship cardiovascular risk. We speculate that (HP) impairs arterial vasodilation via the endothelium and explore potential underlying mechanisms. Isolated vessel relaxation, endothelial function, glomerular filtration rate (GFR), oxidative stress status protein expression were assessed in HP diet mice. Mitochondrial function HP-treated human umbilical vein cells (HUVECs). High (1.3%) for 12 weeks impaired...
Butylphthalide sodium chloride injection for patients with acute cerebral infarction has a certain effect. Although there are several proposed mechanisms of drug action, no related research on improving the inflammatory cytokines that regulate body's immune system through hypothalamus-pituitary-adrenal axis been published.To determine impact butylphthalide and (HPA) after in basal ganglia.Patients were randomly divided into treatment control groups; group received intravenous drips...