A5102017063- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Aluminum Alloys Composites Properties
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Genetic Syndromes and Imprinting
- Ferroptosis and cancer prognosis
- Advanced Welding Techniques Analysis
- Medical Research and Treatments
- Retinal Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Hematological disorders and diagnostics
- Reproductive biology and impacts on aquatic species
- Neonatal and fetal brain pathology
- Mitochondrial Function and Pathology
- Cancer Risks and Factors
- Ovarian cancer diagnosis and treatment
- Metabolism and Genetic Disorders
- Fish Biology and Ecology Studies
- Titanium Alloys Microstructure and Properties
Huangshan University
2022-2025
Peking University
2014-2025
Peking University Cancer Hospital
2014-2025
Ministry of Agriculture and Rural Affairs
2025
Ningbo University
2025
Nanjing University
2024
Shandong University
2024
Beijing Biocytogen (China)
2024
Henan Academy of Sciences
2024
Taizhou People's Hospital
2023-2024
// Lijuan Deng 1 , Yuqin Song Ken H. Young 2 Shimin Hu Ning Ding Weiwei Xianghong Li 3 Yunfei Shi Huiying Huang Weiping Liu Wen Zheng Xiaopei Wang Yan Xie Ningjing Lin Meifeng Tu Lingyan Ping Zhitao Ying Chen Zhang Yingli Sun Jun Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry Education), Lymphoma Unit, Peking University Cancer Hospital & Institute, Beijing, China Department Hematopathology, The Texas MD Anderson Center, Houston, TX, USA Pathology, Correspondence...
Abstract Cervical cancer is an infectious and the most common gynecologic worldwide. E6/E7, early genes of high-risk mucosal human papillomavirus type, play key roles in carcinogenic process cervical cancer. However, little was known about its modulating tumor microenvironment, particular extracellular matrix (ECM). In this study, we found that E6/E7 could regulate multiple ECM proteins, especially collagen triple helix repeat containing 1 (CTHRC1). CTHRC1 highly expressed tissue serum...
Refill friction stir spot welding (RFSSW) is an effective technique for achieving high-quality joints in metallic materials, with rotational speed being a critical parameter influencing joint quality. Current research on RFSSW has primarily focused low-melting-point materials such as aluminum alloys, while limited attention been given to pure copper, material characterized by its high-melting-point and high-thermal-conductivity. This study aims investigate the effects of microstructure...
To investigate the prognostic significance of lymphocyte subsets in newly diagnosed angioimmunoblastic T-cell lymphoma (AITL) patients and track dynamic changes these during treatment. We retrospectively analyzed medical records 56 with AITL. Lymphocyte were assessed by flow cytometry at diagnosis. Receiver operating characteristic curves employed to establish optimal cut-off values for subset assessment. Univariate multivariate analyses used evaluate overall survival (OS) progression-free...
<b>Objectives</b> Previous studies have suggested that the expression and function of placenta-specific microRNAs (miRNAs) are associated with placenta trophoblastic proliferation invasion. This study investigated whether altered miRNAs was involved in development fetal growth. <b>Methods</b> Placenta tissues were obtained from pregnant women large for gestational age (LGA), intrauterine growth retardation (IUGR), appropriate (AGA) infants (<i>n</i> = 30 each group). Real-time quantitative...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with low 5-year survival rate. Treatment options for PDAC patients are limited. Recent studies have shown promising results MRTX1133, KRAS G12D inhibitor that demonstrated potent antitumor activity in various types of tumors mutation. Resistance to inhibitors frequently occurred and one the main reasons treatment failure. Understanding resistance mechanisms novel crucial ensure sustained durable remissions....
In the human placenta, eight ‘placenta‐specific’ micro RNA s (mi s) are exclusively expressed and associated with high cloning frequencies. The expression of placenta‐specific mi is known to be involved in preeclampsia, but understanding these still limited. goal this study was investigate levels localisations placental villi different proliferative abilities during first trimester. Immunohistochemical analyses indicated that trophoblast proliferation ability weight same gestational week Of...
Human epididymis protein 4 (HE4), represented as an epididymis-specific gene and designated a WAP four-disulfide core domain 2 (WFDC2), is amplified in many tumors. However, little known about its clinical significance biological function gastric carcinomas. We found that HE4 was more commonly observed carcinoma tissues than normal significantly correlated with Lauren classification, TNM stage, tumor size by immunohistochemistry. The overall survival rate of patients low expression higher...
In this study, we aimed to explore the correlation between solute carrier family 38 member 4 (SLC38A4) and system A activity in human placentas from pregnancies with abnormal fetal birth weight. We collected consenting women immediately after their full-term babies were born, normal, low weight or macrosomia, used real-time PCR Western blot analysis detect levels of SLC38A4 mRNA protein [also known as sodium-coupled neutral amino acid transport (SNAT4)]. Isotope incorporation assay was...
The purpose of this study was to analyze the expression placenta-specific microRNA miR-517a in maternal serum and placental tissue from low birth weight newborns try detect effects on invasion potential trophoblasts. Placental were collected both (n = 10) normal 20). Expression assessed placenta samples by real-time qRT-PCR. In addition, human trophoblast HTR8/SVneo cells transfected with a 2'-O-methyl oligonucleotide or negative control RNA, measured using transwell migration assays....
According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature diabetic retinopathy, results in the retinal pericytes LDL, including glycated (G-LDL) and heavily oxidized LDL (HOG-LDL). We demonstrate here that inhibits proliferation survival cultured human pericytes. Modified also induced DNA fragmentation bovine Overall, HOG-LDL produced significantly higher...
In this research, Al/Cu thicker plates are overlap-joined based on an experimental simulation to improve the metallurgical quality of laser welding busbar tab interconnect plate in manufacturing production for electric vehicle battery. The influence weld vector route formation, microstructure and mechanical properties has been investigated via stereological microscope, metallographic material tensile testing machine, scanning electron microscope energy dispersive spectroscope. Ductility-dip...
Autophagy, a highly regulated process with dual role (pro-survival or pro-death), has been implicated in adverse pregnancy outcomes. The aim of this study was to explore the mechanism whereby mammalian target rapamycin (mTOR) signaling regulates autophagy by modulating protein O-GlcNAcylation human trophoblasts.HTR8/SVneo cells were incubated serum-free medium for different time intervals treated varying doses Torin1. Protein expression and cell apoptosis detected immunoblotting flow...
Amelioration of depression in patients with post-stroke (PSD) remains challenging.The primary vision was to explore the effect transcranial magnetic stimulation (TMS) combination citalopram on PSD.One hundred eligible who were diagnosed PSD recruited and randomly assigned control group (n = 50) or TMS 50). The controls given (10 mg/d for consecutive 8 weeks), while, addition citalopram, also at 5 Hz once a workday weeks. outcome patient status as reflected by 17-item Hamilton Rating Scale...
Abstract Aim To study the effect and relevant molecular mechanisms of insulin‐like growth factor 2 (IGF2) on proliferative activity first trimester human trophoblasts in vitro . Materials Methods Extravillous cytotrophoblasts (EVCTs) were isolated cultured. Cells cultured with IGF2 at different concentrations was measured using methyl thiazolyl tretrazolium assay. LY294002, a specific inhibitor phosphatidylinositol 3‐kinase (PI3K), used as an indirect indicator possible involvement PI3K...
Glioblastoma multiforme (GBM) is an aggressive tumor of the central nervous system characterized by high rates recurrence, morbidity, and mortality. This study investigated antitumor effects apoptin-derived peptide (ADP) on glioma cells explored underlying mechanisms. The U251, U87, C6 cell lines were used in present study, expression p-Akt, Akt, MMP-9 was determined through Western blotting, quantitative real-time PCR, hematoxylin eosin (HE) staining. Tumor growth evaluated magnetic...