A5029938462- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Neonatal Health and Biochemistry
- Effects and risks of endocrine disrupting chemicals
- Neuroscience of respiration and sleep
- Pituitary Gland Disorders and Treatments
- Human Health and Disease
- Neonatal Respiratory Health Research
- Per- and polyfluoroalkyl substances research
- Intensive Care Unit Cognitive Disorders
- Bone health and osteoporosis research
- Family and Patient Care in Intensive Care Units
- Sexual Differentiation and Disorders
- Gestational Trophoblastic Disease Studies
- Chemical Analysis and Environmental Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Hypothalamic control of reproductive hormones
- Pediatric Pain Management Techniques
- Toxic Organic Pollutants Impact
- Ectopic Pregnancy Diagnosis and Management
- Cancer Risks and Factors
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2024
Belfast Health and Social Care Trust
2023
Rotterdam University of Applied Sciences
2020-2022
Sint Franciscus Gasthuis
2021
Sir Charles Gairdner Hospital
2020
Biogipuzkoa Health Research Institute
2020
The University of Sydney
2020
University Medical Center
2020
Erasmus MC - Sophia Children’s Hospital
2015-2019
Premature delivery is an important risk factor for child mortality and psychiatric, metabolic, cardiovascular disease later in life. In the majority of cases, cause prematurity cannot be identified. Currently, it remains controversial whether abnormal maternal thyroid function during pregnancy increases premature delivery. Therefore, we investigated relation between serum parameters a large prospective population-based study. Serum TSH, free T4 (FT4), T4, TPO antibodies (TPOAbs) were...
The association of thyroid function with risk type 2 diabetes remains elusive. We aimed to investigate the incident and progression from prediabetes in a population-based prospective cohort study.We included 8452 participants (mean age 65 years) measurement, defined by thyroid-stimulating hormone (TSH) free thyroxine (FT4), longitudinal assessment incidence. Cox-models were used TSH FT4 diabetes. Multivariable models adjusted for age, sex, high-density lipoprotein cholesterol, glucose at...
Abnormal maternal thyroid function during pregnancy is associated with various complications. International guidelines advocate the use of population-based trimester-specific reference ranges for tests. When unavailable, an upper TSH limit 2.5 first trimester and 3.0 mU/L second third trimesters recommended. Although interindividual differences in tests can partially be explained by ethnicity, data on influence ethnicity free T4 are sparse.Serum TSH, T4, TPO-antibody levels were determined...
Human chorionic gonadotropin (hCG) is a pregnancy hormone secreted by the placental synctiotrophoblast cell layer that has been linked to fetal growth and various placental, uterine functions. In order investigate effects of hCG on clinical endpoints, knowledge reference range (RR) methodology determinants gestational levels crucial. Moreover, better understanding physiology can improve current screening programs future management. Serum total were determined in 8195 women participating...
Overt hypo- and hyperthyroidism are associated with an increased risk of depression. Little is known about the effects variation in thyroid function within normal range on depression.The objective study was to examine association between normal-range depression.This a cohort 1503 Dutch men women, aged 70.6 (7.3) (mean [SD]) years. At baseline, serum TSH, thyroperoxidase antibody levels, depressive symptoms [Center for Epidemiologic Studies Depression Scale (CES-D)] were assessed. A CES-D 16...
To study the role of thyroid function in dementia, cognitive function, and subclinical vascular brain disease with MRI.Analyses were performed within Rotterdam Study (baseline 1997), a prospective, population-based cohort. We evaluated association thyroid-stimulating hormone (TSH) free thyroxine incident dementia using Cox models adjusted for age, sex, cardiovascular risk factors, education. Absolute risks calculated accounting death as competing factor. Associations test scores (white...
Information on determinants and change of thyroid function over time is sparse conflicting but crucial for clinical interpretation research. Therefore, our aim was to systematically investigate thyroid-stimulating hormone (TSH), free thyroxine (FT4) (as markers function), their mutual relation marker set point) changes in time.We included 9402 participants from the Rotterdam Study not taking medication with available measurements. Repeated measurements (6.5-year interval) were 1225...
Thyroperoxidase antibody (TPOAb) positivity is the main risk factor for thyroid dysfunction during pregnancy and consistently associated with premature delivery. However, underlying mechanism currently unknown. We hypothesized that TPOAb may interfere gestational stimulation induced by hormone human chorionic gonadotropin (hCG). Thyrotropin (TSH), free thyroxine (FT4), TPOAbs, and/or hCG concentrations were measured in early late of 7587 pregnant women from 2 Dutch population-based...
The extent of thyroid disruptive effects phthalates during pregnancy remains unclear.To investigate the association maternal urinary with markers system early pregnancy.Urinary concentrations phthalate metabolites and serum stimulating hormone (TSH), free total thyroxine (FT4 TT4) triiodothyronine (FT3 TT3) were measured in pregnant women Swedish Environmental Longitudinal, Mother child, Asthma allergy study (2007-ongoing), a population-based prospective cohort.In 1,996 included women,...
Although psychological sequelae after intensive care unit (ICU) treatment are considered quite intrusive, robustly effective interventions to treat or prevent these long-term lacking. Recently, it was demonstrated that ICU-specific virtual reality (ICU-VR) is a feasible and acceptable intervention with potential mental health benefits. However, its effect on ICU aftercare in COVID-19 survivors unknown.This study aimed explore the effects of ICU-VR patients' perceived quality of, satisfaction...
Context: Hypertensive disorders during pregnancy are associated with a wide range of maternal and fetal complications, only few risk factors known for the development these pregnancy. Conflicting limited data available on relationship between thyroid (dys)function hypertensive Objective: The objective investigation was to study associations early-pregnancy dysfunction, function within normal range, disorders. Design, Setting, Participants: In early pregnancy, serum TSH, free T4 (FT4),...
Intrauterine adaptation to the outside environment is an important mechanism via which fetus increases its chance thrive after birth. Therefore, various maternal-, pregnancy-, and labor-related factors are potential determinants of thyroid function offspring. Animal studies suggest that very high maternal hormone levels during pregnancy can alter development hypothalamic-pituitary-thyroid axis set point child. However, what extent birth characteristics (including function, smoking, weight)...
Background: Studies indicate that mild to moderate iodine deficiency in pregnancy may have a long-term negative impact on child neurodevelopment. These effects are likely mediated via changes maternal thyroid function, since is essential for the production of hormones. However, availability function during and reference ranges understudied. The aim this study was investigate association between intake pregnancy. Design: In population-based cohort including 2910 pregnant women participating...
Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal function can result adverse pregnancy child developmental outcomes, there is still uncertainty whether bisphenols or interfere with during pregnancy. We aimed to investigate the association of urinary bisphenol A (BPA), S (BPS), F (BPF) early function. This study was embedded Swedish Environmental Longitudinal, Mother child, Asthma allergy (SELMA), a population-based prospective...