A5103048171- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Atmospheric chemistry and aerosols
- Indoor Air Quality and Microbial Exposure
- Neonatal Respiratory Health Research
- Noise Effects and Management
- Chemical Analysis and Environmental Impact
- Delphi Technique in Research
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Tracheal and airway disorders
- Birth, Development, and Health
- Advanced Machining and Optimization Techniques
- Climate Change and Health Impacts
- Neuroscience of respiration and sleep
- Otolaryngology and Infectious Diseases
- Dermatologic Treatments and Research
- Effects of Environmental Stressors on Livestock
- Genetics and Neurodevelopmental Disorders
Harbin Medical University
2024
Karlstad University
2013-2023
Huazhong University of Science and Technology
2020-2021
Ministry of Ecology and Environment
2021
Chongqing University
2021
Stockholm University
2018-2019
École Polytechnique Fédérale de Lausanne
2014
Simon Fraser University
2014
University of Shanghai for Science and Technology
2012
Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent show placental transfer. Emerging research indicates associations between prenatal exposure low birth weight. The aim of this study was to assess the first trimester PFASs weight (BW) in Swedish Environmental, Longitudinal, Mother child, Asthma allergy (SELMA) examine whether differ girls boys.Eight were analyzed maternal serum (median: 10 weeks pregnancy). Associations PFAS outcomes with BW, BW for gestational...
Abstract Preeclampsia is a major cause of maternal and fetal morbidity. Emerging research shows an association with environmental exposures. The present aim was to investigate associations between early pregnancy serum levels perfluoroalkyl substances (PFAS) preeclampsia. Within the Swedish SELMA study, eight PFAS were measured at median 10 gestational weeks cases preeclampsia postnatally identified from registers. Associations individual assessed, adjusting for parity, age, weight smoking....
Abstract Background The ongoing outbreak of novel corona virus disease 2019 (COVID-19) in Wuhan, China, is arousing international concern. This study evaluated whether and when the infected but asymptomatic cases during incubation period could infect others. Methods We collected data on demographic characteristics, exposure history, symptom onset day confirmed cases, which had been announced by Chinese local authorities. potential transmission 50 infection clusters, including 124 cases. All...
The extent of thyroid disruptive effects phthalates during pregnancy remains unclear.To investigate the association maternal urinary with markers system early pregnancy.Urinary concentrations phthalate metabolites and serum stimulating hormone (TSH), free total thyroxine (FT4 TT4) triiodothyronine (FT3 TT3) were measured in pregnant women Swedish Environmental Longitudinal, Mother child, Asthma allergy study (2007-ongoing), a population-based prospective cohort.In 1,996 included women,...
Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal function can result adverse pregnancy child developmental outcomes, there is still uncertainty whether bisphenols or interfere with during pregnancy. We aimed to investigate the association of urinary bisphenol A (BPA), S (BPS), F (BPF) early function. This study was embedded Swedish Environmental Longitudinal, Mother child, Asthma allergy (SELMA), a population-based prospective...
Background Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure adverse health effects. Concerns have been raised with special focus childhood development. Methods Perfluoroheptanoic acid (PFHpA), perfluorooctanoic (PFOA), perfluorononanoic (PFNA), perfluorodecanoic (PFDA), perfluoroundecanoic (PFUnDA),...
The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. child is followed age 5 years, prospective characterization exposures during this critical period. Key exposure domains include indoor outdoor air pollutants, inhalation, ingestion dermal uptake...
The incidence of asthma and allergy has increased throughout the developed world over past decades. During same period time, use industrial chemicals such as phthalates, commonly used plasticizers in polyvinylchloride (PVC) flooring material, increased. aim this study was to investigate whether PVC home children age 1-5 years is associated with development 5- 10-year follow-up investigations (n = 3228). Dampness Buildings Health Study (DBH Study) commenced 2000 Värmland, Sweden. current...
Abstract Context Establishing reference ranges as well identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation optimizing research efforts. However, such data are sparse, specifically triiodothyronine measurements, most studies do not take into account antibodies or human chorionic gonadotropin. Objective To determine to identify/quantify TSH, free T4 (FT4), (FT3), total (TT4), (TT3). Design, Setting, Participants This...
Abstract Humans are continuously exposed to chemicals with suspected or proven endocrine disrupting (EDCs). Risk management of EDCs presents a major unmet challenge because the available data for adverse health effects generated by examining one compound at time, whereas real‐life exposures mixtures chemicals. In this work, we integrate epidemiological and experimental evidence toward whole mixture strategy risk assessment. To illustrate, conduct following four steps in case study: (1)...
Abstract DNA methylation (DNAm) profiles in central airway epithelial cells (AECs) may play a key role pathological processes asthma. The goal of the current study is to compare diagnostic performance DNAm markers across three tissues: AECs, nasal (NECs), and peripheral blood mononuclear (PBMCs). Additionally, we focused on results using machine learning algorithm context multi-locus effects evaluate optimal subset CpG sites. We obtained 74 subjects with asthma 41 controls from 15 14 NECs,...
Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment then become a source for human uptake. The aim of study was to investigate whether residential PVC flooring related urinary levels phthalate metabolites determined pregnant women. data were from Swedish SELMA where sampling conducted during time period 2007-2010. Spot urine samples 1674 women at end first trimester analyzed 14 seven one...
Vitamin D deficiency has been associated with the increased risk of many diseases, especially during early life. Exposure to some toxic metals may decrease vitamin levels in adults and children previous studies. However, less is known about associations maternal exposure pregnancy newborns' status. We conducted a prospective cohort study investigate relationships between urine metal mixtures Urine samples 598 pregnant women were collected each trimester cord blood newborns at delivery. The...
Background: Severe maternal iodine deficiency can impact fetal brain development through effects on and/or thyroid hormone availability. The of mild-to-moderate function are less clear. aim was to investigate the association urinary concentration corrected for creatinine (UI/Creat) with and autoantibodies in a iodine-deficient pregnant population. Methods: This study embedded within Swedish Environmental Longitudinal, Mother child, Asthma allergy (SELMA) study. Clinical reference ranges were...
Phthalates are widely used in consumer products. Exposure to phthalates can lead adverse health effects humans, with early-life exposure being of particular concern. Phthalate occurs mainly through ingestion, inhalation, and dermal absorption. However, our understanding the relative importance different routes is incomplete. This study estimated intake five from residential indoor environment for 455 Swedish pregnant women SELMA using phthalate mass fraction dust compares these total daily...
Human chorionic gonadotropin (hCG) is produced by the placenta and plays an essential role in maintenance of pregnancy. Endocrine disrupting chemicals (EDCs) have potential to interfere with functions related production secretion hCG; however associations between exposure EDCs hCG concentrations humans remain be elucidated.To investigate association urinary, serum plasma during pregnancy concentrations.We utilized data form Swedish Environmental Longitudinal, Mother child, Asthma allergy...
Abstract Aim This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods From 2007 to 2010, we used liquid chromatography‐tandem mass spectrometry, adjusted for creatinine, analyse 14 metabolites and one replacement the urine of 1062 Swedish mothers at a median 10 weeks pregnancy. determine any associations between croup, wheezing otitis their offspring until 12 months age, using logistic regression, potential...