A5081224953- Microscopic Colitis
- Inflammatory Bowel Disease
- COVID-19 and Mental Health
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- COVID-19 and healthcare impacts
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Diagnosis and treatment of tuberculosis
- Gastroesophageal reflux and treatments
- Colorectal Cancer Treatments and Studies
- Chronic Disease Management Strategies
- Autoimmune and Inflammatory Disorders
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Tumor Research and Treatment
- Adolescent and Pediatric Healthcare
- Iron Metabolism and Disorders
- Celiac Disease Research and Management
- Multiple and Secondary Primary Cancers
- Health, psychology, and well-being
University of Manitoba
2011-2025
University of Chicago
2019-2021
University of Toronto
2020
CancerCare Manitoba
2020
AIDS Vancouver
2020
Queen's University
2016
University of Winnipeg
2012
Summary Background Comorbidity is an important predictor of how disease course in inflammatory bowel (IBD) evolves. Aims To determine pre‐diagnosis relative rates (RR) and post‐diagnosis hazard ratios (HR) component diseases the Charlson Index (CCI) a cohort study persons with IBD. Methods The University Manitoba IBD Epidemiology Database includes all Manitobans from 1 April 1984 through 31 March 2018 matched controls. All outpatient physician claims hospital discharge abstracts were...
Abstract Background Ustekinumab has been recently approved for the treatment of moderately to severely active ulcerative colitis (UC). The registry trials ustekinumab in UC demonstrated efficacy and safety, but data on real-world outcomes are limited. We describe effectiveness safety patients with from 2 US tertiary inflammatory bowel disease centers. Methods Patients treated at NYU Langone Health (New York, New York) University Chicago Medical Center (Chicago, Illinois) between January 2016...
Abstract Background Microscopic colitis (MC) is an inflammatory disease of the colon, causing chronic diarrhea, with 2 histologic sub-types, collagenous and lymphocytic colitis. It tends to affect older individuals, a female predominance. MC diagnosed in 10% patients across all age groups, 20% those over 70 among persons undergoing colonoscopy for watery diarrhea. However, there paucity data Canadian populations, thus we performed population-based study Manitoba assess prevalence MC. Aims...
Abstract Background Inflammatory bowel disease (IBD) significantly impacts both physical and mental health, with patients experiencing elevated levels of anxiety depression. Nutritional management is also crucial, as dietary choices can influence symptoms. Despite the importance integrated health nutrition services, numerous barriers, such limited awareness access, contribute to suboptimal engagement among IBD. Aims We sought assess uptake psychologist dietician services in a clinical...
Abstract Background In Canada, approximately 0.8% of people have inflammatory bowel disease (IBD), which is estimated to rise by 2.4% annually over the next decade. Iron deficiency anaemia (IDA) common in with IBD, who can experience high levels fatigue that may be alleviated iron treatment. Intravenous (IV) recommended for are intolerant or unresponsive oral those require rapidly. Ferric carboxymaltose (FCM) and ferric derisomaltose (FDI) high-dose, rapid-infusion formulations approved...
Abstract Background We aimed to determine patient perspectives on inflammatory bowel disease (IBD) research participation and potential changes related the COVID pandemic experience. Methods Participants of population-based University Manitoba IBD Research Registry were surveyed 3/2022-3/2023. The survey inquired about views in pre-, peri- post-COVID era. Questions included aspects from home or in-person, reimbursement, results reporting, study design. determined a rank order reasons for...
Objectives Surveillance colonoscopy is thought to prevent colorectal cancer (CRC) in patients with long-standing colonic IBD, but data regarding the frequency of surveillance and findings thereof are lacking. Our aim was determine whether consecutive negative colonoscopies adequately predict low neoplastic risk. Design A multicentre, multinational database IBD colitis without high-risk features undergoing regular CRC constructed. ‘negative’ predefined as a technically adequate procedure...
ABSTRACT We have demonstrated the effectiveness and safety of combining cyclosporine vedolizumab to treat ulcerative colitis (UC). present 2 cases hospitalized acute severe UC who had failed therapy with antitumor necrosis factor were treated successfully induction safely bridged ustekinumab maintenance therapy. Both patients avoided colectomy. There no adverse events. propose this novel treatment combination in medically resistant UC.
Abstract Background Proton pump inhibitors (PPIs) have an impact on the gut microbiome. We investigated whether increased use of PPIs was associated with a diagnosis inflammatory bowel disease (IBD). Methods The University Manitoba IBD Epidemiology Database includes all Manitobans diagnosed between 1984 and 2018 age-, sex-, geography-matched control subjects comprehensive prescription drug data from April 1995. Subjects were considered to be users if they received 2 PPI prescriptions....
Background & AimsColonoscopic surveillance is recommended in patients with colonic inflammatory bowel disease (IBD) given their increased risk of colorectal cancer (CRC). We aimed to develop and validate a dynamic prediction model for the occurrence advanced neoplasia (aCRN, including high-grade dysplasia CRC) IBD.MethodsWe pooled data from 6 existing cohort studies Canada, The Netherlands, United Kingdom, States. Patients IBD an indication CRC were included if they underwent at least 1...
Abstract We have previously demonstrated that histological normalization in ulcerative colitis (UC) is associated with superior maintenance of remission outcomes. This single-center, retrospective case-control study assessed outcomes after the therapeutic de-escalation UC patients who achieved histologic normalization. A total 111 were included, which 24 underwent de-escalation, and 87 without changes. The most commonly withdrawn therapy was aminosalicylates (50%), followed by...
Complete histologic normalization is associated with improved clinical outcomes in ulcerative colitis (UC). However, it currently unknown what effect achieving has on the development of dysplasia.We performed a retrospective analysis 495 patients confirmed diagnosis UC from tertiary center. Patients were categorized according to best assessment they had during their disease course: normalization, quiescence, or persistent activity. We assessed dysplasia rates these patient groups after 8...
IPAA is rarely performed in patients with a known diagnosis of Crohn's disease, although it may be done highly selected an absence perianal disease or small bowel inflammation. Patients preoperative are, however, at increased risk developing the pouch. pouch can also occur people ulcerative colitis; unknown whether this phenotype similar to classic involving intact bowel, distinct entity.This study aimed describe pouch, including luminal inflammation, and fibrostenotic perforating...
Medications are major cost drivers in the treatment of patients with inflammatory bowel disease. Recent analyses suggest that there is no added efficacy continuing nor harm stopping 5-aminosalicylate (ASA) therapy disease escalated to biological therapies or tofacitinib. We assessed cost-effectiveness discontinuing 5-ASA ulcerative colitis on tofacitinib, compared therapy.We performed a analysis biologic and tofacitinib same without 5-ASA. Our primary outcome was determine whether...
Inflammatory bowel disease (IBD) can lead to substantial impairments of quality-of-life. Clinical guidelines and quality indicators aid physicians in practice but may not reflect the perspectives experiences patients with IBD. To address this, objectives this study were understand patient IBD care explore priorities.Based on a convenience sample 36 participants, five focus groups completed at four sites across Canada. Data analyzed using deductive thematic analysis approach assess emergent...
To assess the association between maladaptive health behaviours and elevated mental (MH) symptoms during COVID-19 pandemic among persons with inflammatory bowel disease (IBD).Participants of population-based University Manitoba IBD Research Registry (n = 2,942) were invited to participate in a survey November 2020, regarding their experiences pandemic. Maladaptive included increased use alcohol, marijuana, cigarettes, reduced exercise relative pre-pandemic levels. Clinically significant MH...
This study examines colonic histological features in ulcerative colitis [UC] endoscopic remission to determine which cell types and biopsy sites best predict a patient's likelihood of remaining remission.This is retrospective chart, endoscopy histology review 166 patients with UC followed single inflammatory bowel disease practice over median 6 years [range, 2-11 years]. Clinical was based on global physician assessment colonoscopy reports, clinical relapse chart review. Histological...
We aimed to determine both direct (medical) and indirect (lost wages) costs of IBD the association between degree IBD-related disability extent costs.Persons age 18-65 from population-based University Manitoba Research Registry completed a survey including Disability Index (IBDDI) questions related employment, missed work (absenteeism), reduced productivity at (presenteeism). Administrative health data surgeries, hospitalizations, physician claims, prescriptions were linked assessed. To...
Gastroenterology training in Canada is guided by the Royal College of Physicians and Surgeons Canada. Resident perspectives on degree heterogeneity across programs have not been previously surveyed.This study aims to evaluate current Canadian adult gastroenterology experience from a resident perspective provide insight into among programs.A survey designed three residents was distributed trainees attending Residents-in-Training course at Digestive Diseases Week 2018. Categorical data...
Abstract Background Hospitalization admissions and discharge databases (DAD) using the International Classification of Diseases (ICD) codes are often used to describe epidemiology Clostridioides difficile infections (CDI) among those with Inflammatory bowel disease (IBD), even though DAD CDI definition can miss many cases CDI. There no data comparing assessment IBD by versus laboratory diagnosis. We a population-based dataset determine effect diagnosis on IBD. Methods linked University...