A5029506257- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Liver Diseases and Immunity
- Intraperitoneal and Appendiceal Malignancies
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diverticular Disease and Complications
- Photoacoustic and Ultrasonic Imaging
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
University Medical Center Utrecht
2020-2025
Utrecht University
2024
Abstract Background Patients with colonic inflammatory bowel disease (IBD) undergo endoscopic surveillance to detect and remove colorectal neoplasia (CRN). Although high-definition dye-based chromo-endoscopy (HD-CE) is the recommended modality in guidelines, white light endoscopy (HD-WLE) matched procedural time may yield similar detection rates. We designed a non-blinded, randomized controlled trial four academic hospitals aiming compare three techniques IBD patients for outcome of CRN...
Background It remains unclear if the increased colorectal neoplasia detection rate in inflammatory bowel disease (IBD) by high-definition (HD) dye-based chromoendoscopy compared with HD white-light endoscopy is due to enhanced contrast or inspection times. Longer withdrawal times may yield similar rates as found chromoendoscopy. Objective To compare for segmental re-inspection and chromoendoscopy, using single-pass an additional control group. Design In a multicentre, randomised controlled...
Background & AimsColonoscopic surveillance is recommended in patients with colonic inflammatory bowel disease (IBD) given their increased risk of colorectal cancer (CRC). We aimed to develop and validate a dynamic prediction model for the occurrence advanced neoplasia (aCRN, including high-grade dysplasia CRC) IBD.MethodsWe pooled data from 6 existing cohort studies Canada, The Netherlands, United Kingdom, States. Patients IBD an indication CRC were included if they underwent at least 1...
Prior studies on the effect of smoking risk colitis-associated colorectal neoplasia (CRN) have reported conflicting results. We aimed to further elucidate association between smoking, including possible dose-effects, and development in patients with inflammatory bowel disease (IBD).
Abstract Background Patients with inflammatory bowel disease (IBD) undergo surveillance colonoscopies at fixed intervals to reduce the risk of colorectal cancer (CRC). Taking patients’ preferences for determining strategies into account could improve adherence and patient satisfaction. This study aimed determine CRC in IBD. Methods We conducted a web-based, multicenter, discrete choice experiment among adult IBD patients an indication surveillance. Individuals were repeatedly asked choose...
Abstract Background Patients with inflammatory bowel disease (IBD) undergo surveillance colonoscopies at fixed intervals to reduce the risk of colorectal cancer (CRC). Taking patients’ preferences for determining strategies into account could improve adherence and patient satisfaction. This study aimed determine preference heterogeneity CRC in IBD. Methods We conducted a web-based, multicentre, discrete choice experiment among adult IBD patients an indication surveillance, treated two...
Abstract Background There is an increasing demand of agents that can promote mucosal healing in Inflammatory Bowel Disease (IBD). Wnt/β-catenin signaling plays a critical role epithelial regeneration and repair, stimulating the damaged epithelium by modulating Wnt has been suggested as potential treatment option for IBD. To guide development therapeutic molecules IBD, understanding how may be altered IBD tissues required. While earlier work showed pathway gene expression UC tissues, these...