A5022662967- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Body Image and Dysmorphia Studies
- Asthma and respiratory diseases
- Photodynamic Therapy Research Studies
- Allergic Rhinitis and Sensitization
- melanin and skin pigmentation
- Circadian rhythm and melatonin
- Autoimmune Bullous Skin Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nonmelanoma Skin Cancer Studies
- Acne and Rosacea Treatments and Effects
- T-cell and B-cell Immunology
- Infectious Diseases and Mycology
- Cutaneous lymphoproliferative disorders research
- Health Systems, Economic Evaluations, Quality of Life
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Urticaria and Related Conditions
- Obsessive-Compulsive Spectrum Disorders
- Antifungal resistance and susceptibility
- Hidradenitis Suppurativa and Treatments
- Cutaneous Melanoma Detection and Management
- Liver Diseases and Immunity
University of Michigan
2019-2025
Tohoku University
2022-2024
National Disaster Medical Center
2024
Woodruff Health Sciences Center
2024
Akita University Hospital
2022
Japan Food Research Laboratories
2022
University of California, San Francisco
2015-2021
Michigan Medicine
2021
Kyorin University Hospital
2020
Michigan United
2019
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis skin other internal organs. However, the main cellular participants in SSc remain incompletely understood. Here using differentiation trajectories at single cell level, we demonstrate dual source matrix deposition from both myofibroblasts endothelial-to-mesenchymal-transitioning cells (EndoMT). We further define central role...
Erythrodermic psoriasis (EP) is a rare and severe variant of vulgaris, with an estimated prevalence 1%-2.25% among psoriatic patients. The condition presents distinct histopathologic clinical findings, which include generalized inflammatory erythema involving at least 75% the body surface area. pathogenesis EP not well understood; however, several studies suggest that disease associated predominantly T helper 2 (Th2) phenotype. Given morbidity potential mortality condition, there need for...
<h3>Importance</h3> Melanoma in situ (MIS) is increasing incidence, and expert consensus opinion recommends surgical excision for therapeutic management. Currently, wide local (WLE) the standard of care. However, Mohs micrographic surgery (MMS) now used to treat a growing subset individuals with MIS. During MMS, unlike WLE, entire cutaneous margin evaluated intraoperatively tumor cells. <h3>Objective</h3> To assess outcomes patients MIS treated MMS compared those WLE. <h3>Design, Setting,...
Psoriasis patients demonstrate high interest in the role of diet on their skin condition. However, data are lacking to describe dietary interventions among psoriasis and associated outcomes. This study aims identify common habits, perceptions with psoriasis, examine patient-reported outcomes response these interventions. We administered a 61-question survey National Foundation membership asking about modifications, responses, perceptions. A total 1206 responded survey. Compared age-...
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate single-cell RNA sequencing, spatial transcriptomics, immunostaining to provide an unprecedented view of the pathogenesis HS, characterizing main cellular players defining their interactions. We found striking layering HS infiltrate identified contribution 2 fibroblast subtypes (SFRP4+ CXCL13+) in orchestrating this...
Prurigo nodularis (PN) is a chronic neuroimmune skin disease characterized by bilaterally distributed pruritic hyperkeratotic nodules on extremities and trunk. Neuroimmune dysregulation scratching are believed to both induce maintain the characteristic lesions.
Only a few studies have compared frequencies of photodermatoses among different races and skin types. This is an extension study performed by Kerr Lim evaluates the frequency in African-Americans with Caucasians same institution during 8-year period.
It is well known that psoriasis significantly impacts patients' quality of life (QoL). With the introduction improved treatment modalities with biologic agents, more patients moderate to severe are able achieve better results as measured by Psoriasis Area and Severity Index (PASI). PASI 75 indicates a 75% or greater reduction in scores from baseline indicative excellent disease improvement. newer agents such secukinumab, ixekizumab brodalumab, now capable achieving 90, introducing additional...
<ns4:p>Phototherapy involves repeated exposure of the skin to ultraviolet light treat various inflammatory conditions such as psoriasis. Recent studies have identified specific immunologic effects phototherapy that may underlie efficacy. Furthermore, recent advancements been made in developing safe and effective targeted modalities for difficult-to-treat areas scalp Targeted form excimer laser holds potential more aggressive, treatment long-lasting remission Phototherapy is now also used...