A5101620742- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- Hidradenitis Suppurativa and Treatments
- Autoimmune and Inflammatory Disorders
- Insect Resistance and Genetics
- Oral Health Pathology and Treatment
- Insect-Plant Interactions and Control
- Systemic Sclerosis and Related Diseases
- Nanocluster Synthesis and Applications
- Neurobiology and Insect Physiology Research
- Bone health and osteoporosis research
- CRISPR and Genetic Engineering
- Bone health and treatments
- Inflammatory Myopathies and Dermatomyositis
- Photoacoustic and Ultrasonic Imaging
- Eosinophilic Disorders and Syndromes
- Advanced biosensing and bioanalysis techniques
- Hippo pathway signaling and YAP/TAZ
- Rheumatoid Arthritis Research and Therapies
- Vascular Tumors and Angiosarcomas
- Whipple's Disease and Interleukins
- Skin Diseases and Diabetes
- Cancer and Skin Lesions
University of Michigan
2011-2025
Tongren Hospital
2017-2025
Shanghai Jiao Tong University
2017-2025
Sun Yat-sen Memorial Hospital
2022-2024
Sun Yat-sen University
2022-2024
Peking Union Medical College Hospital
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Michigan United
2020-2021
National Clinical Research Center for Digestive Diseases
2020
China Jiliang University
2017-2018
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by abscess formation and development of multiple draining sinus tracts in the groin, axillae, perineum. Using proteomic transcriptomic approaches, we responses HS depth, revealing immune centered on IFN-γ, IL-36, TNF, with lesser contribution from IL-17A. We further identified B cells plasma cells, associated increases immunoglobulin production complement activation, as pivotal players...
Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease the skin, is incompletely understood. Here we demonstrate, using combination single cell and spatial RNA sequencing, IL-36 dependent amplification IL-17A TNF responses in absence neutrophil proteases, which primarily occur within supraspinous layer psoriatic epidermis. We further show that subset SFRP2 + fibroblasts psoriasis contribute to immune network through transition pro-inflammatory state. fibroblast...
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis skin other internal organs. However, the main cellular participants in SSc remain incompletely understood. Here using differentiation trajectories at single cell level, we demonstrate dual source matrix deposition from both myofibroblasts endothelial-to-mesenchymal-transitioning cells (EndoMT). We further define central role...
IL-17C is an epithelial cell-derived proinflammatory cytokine whose transcriptional regulation remains unclear. Analysis of the IL17C promoter region identified TCF4 as putative regulator, and siRNA knockdown in human keratinocytes (KCs) increased IL17C. stimulation KCs (along with IL-17A TNF-α stimulation) decreased NFKBIZ ZC3H12A expression IL-17RA/RE-dependent manner, thus creating a feedback loop. (MCPIP1/Regnase-1), immune-response also following knockdown, NFKBIZ, IL1B, IL36G, CCL20,...
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i) stands as effective approach for psoriasis treatment, the potential efficacy application TYK2i remains unexplored. Herein, carbomer/alginic acid hydrogel is embedded with borneol (BO) new carrier achieving enhanced transdermal permeation and...
Abstract CCN2 is widely regarded as a profibrotic factor involved in fibrotic disorders by regulating extracellular matrix (ECM). We report here that functions critical cell cycle regulator primary human dermal fibroblasts (HDFs). siRNA‐mediated knockdown of halted proliferation HDFs, which was rescued siRNA‐resistant expression vector. Furthermore, caused significant accumulation cells G1/G0 phase and blocked entry into S‐phase. Mechanistically, cyclin E CDK4/cyclin D nuclear translocation,...
This article presents a simple label-free detection of nucleic acids by using Pt@mesoporousSiO2 as "smart" reporter, whose pores are first capped single-stranded (ss) probe DNA. The signal is then amplified the TMB oxidation reaction catalysed Pt NPs while hybridizing with complementary ss target DNA, which makes mesoporous SiO2 open through hybridization.
Abstract Spodoptera litura is a widespread polyphagous insect pest that can develop resistance and cross-resistance to insecticides, making it difficult control. Insecticide exposure has previously been linked with induction of specific olfactory-related proteins, including some chemosensory proteins (CSPs) odorant-binding (OPBs), which may disrupt detection environmental factors reduce fitness. However, functional evidence supporting insecticide OBPs/CSPs mediation remains unknown. Here we...
CRISPR/Cas9 has been proposed as a treatment for genetically inherited skin disorders. Here we report that CRISPR transfection activates STING-dependent antiviral responses in keratinocytes, resulting heightened endogenous interferon (IFN) through induction of IFN-κ, leading to decreased plasmid stability secondary the cytidine deaminase gene APOBEC3G. Notably, CRISPR-generated KO keratinocytes had permanent suppression IFN-κ and IFN-stimulated (ISG) expression, hypermethylation IFNK...
Dual-modal imaging contrast agents with unique X-ray computed tomography (CT) and optical capabilities have attracted much attention in recent years. Herein, the new silica hybrid nanocomposites containing Au nanoparticles FITC dyes (FITC–Au@SiO2) were investigated as this kind of agent. TEM characterization showed that as-synthesized FITC–Au@SiO2 nanoprobes uniform morphology average size 90 nm. After PEGylation, obtained FITC–Au@SiO2@PEG exhibited good dispersion stability under different...
Abstract Background Psoriasis is a common chronic inflammatory skin disease that features the abnormal proliferation of keratinocytes. This could partly result from disturbances in vitamin A metabolism. Changes psoriasis patients levels retinol-binding protein 4 (RBP4), carrier retinol (vitamin A); transmembrane stimulated by retinoic acid 6 (STRA6); and other metabolic molecules have not yet been fully established. Therefore, we investigated A-related proteins mice with imiquimod...
Background . Psoriasis is an immune-mediated chronic inflammatory skin disorder in which the dysregulation of immune cells plays important role its development. Tumor necrosis factor- (TNF-) α antagonists affect repertoire, while TNF- -induced protein 3 (TNFAIP3) has a protective against deleterious effects inflammation and participates regulation. Objective We investigated regulation TNFAIP3 pathogenesis psoriasis determined whether it involved antipsoriatic effect antagonists. Methods mRNA...
Spodoptera litura (S. litura) is one of the most serious agricultural insect pests worldwide. Takeout (TO) involved in a variety physiological and biochemical pathways performs various biological functions. We characterized 18 S. TO genes investigated their differential responses to insecticides sex pheromones. All predicted proteins have two Cysteines that are unique N-terminal family contain four highly conserved Prolines, Glycines, Tyrosine. The expression levels seven male antennae were...
Cytokines like IL-17A have been consistently found to be elevated in psoriatic lesional skin, and therapeutic antibodies IL-17 demonstrated efficacy treating skin joint disease. However, results about the circulating cytokines psoriasis patients remained controversial. Anticytokine autoantibodies (ACAAs) were detected various autoimmune diseases but largely unknown psoriasis. We aimed investigate serum levels of ACAAs patients. The study included 44 biologics-naive 40 healthy controls. Serum...
A new strategy for signal amplification by labeling DNA with Pd/GO nanoparticles, which further act as catalysts to reduce copper ions metallic enhance the signal, is presented.
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that highly associated with inflammatory bowel disease (IBD). Certain PG patients no systemic disorders have been diagnosed idiopathic PG. This study sought to clarify the difference between IBD and based on clinical features, laboratory tests, medications.Twelve 24 PG, who were hospitalized in Peking Union Medical College Hospital from 2000 2017, retrospectively categorized into group control group, respectively. Data of...
Abstract Background The ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is a rare X‐linked genodermatosis characterized by noninflammatory spiny follicular hyperkeratosis, severe photophobia, non‐scarring alopecia with variable severities. IFAP results from mutations in the gene encoding membrane‐bound transcription factor peptidase, site 2 ( MBTPS2 ). Methods We present an 11‐year‐old male typical clinical features of syndrome, including diffuse psoriasiform plaques,...