A5039089177- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Dermatology and Skin Diseases
- Immune cells in cancer
- S100 Proteins and Annexins
- RNA modifications and cancer
- Psoriasis: Treatment and Pathogenesis
University of Toronto
2022-2024
Sun Yat-sen University
2024
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i) stands as effective approach for psoriasis treatment, the potential efficacy application TYK2i remains unexplored. Herein, carbomer/alginic acid hydrogel is embedded with borneol (BO) new carrier achieving enhanced transdermal permeation and...
A diverse antibody repertoire is essential for humoral immunity. Antibody diversification requires the introduction of deoxyuridine (dU) mutations within immunoglobulin genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR). dUs are normally recognized excised by base excision repair (BER) protein uracil-DNA glycosylase 2 (UNG2). However, FAM72A downregulates UNG2 permitting persist trigger SHM CSR. How promotes degradation unknown. Here, we show that recruits a...
In the tumor microenvironment (TME), cells secrete a cytokine known as transforming growth factor-β (TGF-β), which polarizes tumor-associated neutrophils (TANs) towards protumor phenotype. this work, C57BL/6 mice with TGF-β1 gene knocked out selectively in myofibroblasts receive orthotopic implantation of Lewis lung carcinoma (LLC). Then, TANs' differentiation and are studied both vivo vitro, to examine potential effects TGF-β levels TME on neutrophil polarization cancer progression....