A5102735253- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Psoriasis: Treatment and Pathogenesis
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Cholangiocarcinoma and Gallbladder Cancer Studies
- interferon and immune responses
- Viral-associated cancers and disorders
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Bioactive Compounds and Antitumor Agents
- Dermatology and Skin Diseases
- Virus-based gene therapy research
- Advanced Breast Cancer Therapies
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Microbial Applications in Construction Materials
- Complement system in diseases
Sun Yat-sen Memorial Hospital
2021-2024
Sun Yat-sen University
2021-2024
Affiliated Hospital of Hebei University
2020-2024
Hebei Medical University
2023
Chifeng University
2020
Soochow University
2014-2018
First Affiliated Hospital of Soochow University
2018
Soochow University
2014-2016
Hanzhong People's Hospital
2016
Zhejiang Cancer Hospital
2010-2013
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i) stands as effective approach for psoriasis treatment, the potential efficacy application TYK2i remains unexplored. Herein, carbomer/alginic acid hydrogel is embedded with borneol (BO) new carrier achieving enhanced transdermal permeation and...
Microabscess of neutrophils in epidermis is one the histological hallmarks psoriasis. The axis neutrophil-keratinocyte has been thought to play a critical role pathogenesis However, features and mechanism interaction between two cell types remain largely unknown. Herein, we found that blood were increased psoriasis patients, positively correlated with disease severity highly expressed CD66b, but not CD11b CD62L compared healthy controls. Keratinocytes high levels psoriasis-related...
Psoriasis is a common inflammatory skin disease resulting from an interplay of keratinocytes and immune cells. Previous studies have identified essential role autophagy in the maintenance epidermal homeostasis including proliferation differentiation. However, much less known about autophagy-related proteins cutaneous response. Herein, we showed that ULK1, key autophagic initiator, its phosphorylation at Ser556 were distinctively decreased epidermis lesional psoriasis patients. Topical...
In this study, we have analyzed both administrative and clinical data from our hospital during 2002 to 2012 evaluate the influence of government medical policies on reducing abandonment treatment in pediatric patients with acute lymphoblastic leukemia. Two funding for catastrophic diseases new rural cooperative care system (NRCMS) were initiated 2005 2011, respectively. About 1151 children diagnosed leukemia enrolled study period 316 cases abandoned treatment. Statistical differences sex,...
Treatment with TNF-α inhibitors improve psoriasis minimize/minor neutrophils infiltration and CXCL-1/8 expression in psoriatic lesions. However, the fine mechanism of initiating inflammation by tuning keratinocytes is unclear. Our previous research identified deficiency intracellular galectin-3 was sufficient to promote characterized neutrophil accumulation. This study aims investigate whether participated development through dysregulating expression.
A survey of the clinical data on acute myeloid leukemia (AML) over past 10 years in treatment center Children's Hospital was presented. The aim study to identify factors influencing abandonment rate (AR) AML. Of 474 AML cases examined, 264 were abandoned (55.7%). most important factor affecting AR appeared be subtype-that is, M3 versus non-M3 (42% vs. 60%). Patient age observed closely related AR-the older patients, lower AR-and infants had highest prevalence (84.2%). patient's residential...
Cytokines like IL-17A have been consistently found to be elevated in psoriatic lesional skin, and therapeutic antibodies IL-17 demonstrated efficacy treating skin joint disease. However, results about the circulating cytokines psoriasis patients remained controversial. Anticytokine autoantibodies (ACAAs) were detected various autoimmune diseases but largely unknown psoriasis. We aimed investigate serum levels of ACAAs patients. The study included 44 biologics-naive 40 healthy controls. Serum...
Objective To explore a chemotherapeutic regimen suitable for non-small cell lung cancer (NSCLC) in elderly patients. Methods A total of 68 patients with NSCLC (stage Ⅲb/Ⅳ )were equally and randomly divided into single-agent combinded groups. Patients group received gemcitabine 1000 mg/m~2 at Days 1 8 21-day cycle. Those combined combination carboplatin AUC5 Day 2 The drugs were intravenously administered. All 3 cycles treatment. Results In groups, CR 1, PR 12 13, response rates 38% 41%...
Duodenal adenocarcinoma (DA) is a subtype of small bowel (SBA).Compared with gastrointestinal cancers such as colorectal cancer and gastric cancer, SBA less common.For patients advanced metastatic DA, chemotherapies are usually extrapolated from but the therapeutic effects remain undefined.Herein, we reported 50-year-old female patient whom was diagnosed stage IV DA metastasis to both lungs retroperitoneal lymph nodes.The next generation sequencing (NGS) using panel consisting 168 related...
Mucinous adenocarcinoma is a rare type of colorectal cancer (CRC) associated with poor prognosis, particularly when it includes signet ring cell components. Furthermore, its rate microsatellite instability-high (MSI-H) significantly higher compared to non-mucinous adenocarcinoma. Immunotherapy has emerged as the standard treatment for MSI-H metastatic CRC (mCRC). In KEYNOTE-177 trial, individuals advanced exhibiting or mismatch repair deficiency (dMMR), pembrolizumab single agent...
10031 Background: In this multicenter NCI CTEP-sponsored trial [funded by R21CA13763301A1 (AN), U01CA62461 (RK), and U01CA62487 (PL)], we combined the mTOR inhibitor temsirolimus with cixutumumab, a fully humanized IgG1 monoclonal antibody directed at insulin growth factor-1 receptor (IGF-1R), on basis of preclinical data suggesting that combination could putatively overcome resistance observed when individual agents were used as monotherapy in Ewing's sarcoma. Methods: Patients received...
The appearance of highly effective and low toxic drugs enables an increasing number advanced non-small cell lung cancer (NSCLC) patients to receive third-line therapy. No other standard choice for therapy aside from erlotinib is possible. This study respectively explores the efficacy safety single chemotherapy, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), doublet chemotherapy in NSCLC treatment.This included 115 stage IIIb or IV who were retrospectively reviewed...
Objective: To observe the clinical efficacy of neoadjuvant chemotherapy combined with laparoscopic surgery in patients middle and low rectal cancer its effect on serum VEGF level quality life.
 Methods: Retrospective analysis was performed 80 admitted to Baoding No.1 Central Hospital from June 2018 2020.They were randomly divided into two groups. Patients control group underwent radical surgery, while those experimental before surgery. The differences various surgical indicators between...