A5010037994- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Heart rate and cardiovascular health
- Cardiovascular Syncope and Autonomic Disorders
- Neural dynamics and brain function
- Cardiac pacing and defibrillation studies
- Organic Electronics and Photovoltaics
- Diabetes Management and Research
- stochastic dynamics and bifurcation
- Diabetes Treatment and Management
- Neuroscience and Neural Engineering
- Conducting polymers and applications
- IgG4-Related and Inflammatory Diseases
- Mesoporous Materials and Catalysis
- Machine Learning in Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroscience of respiration and sleep
- Renin-Angiotensin System Studies
- Supramolecular Self-Assembly in Materials
- Complex Systems and Time Series Analysis
- Blood Pressure and Hypertension Studies
- Obstructive Sleep Apnea Research
Keio University
2023-2024
National Institute of Advanced Industrial Science and Technology
2021-2023
Yamagata City Hospital Saiseikan
2013-2019
University of Tsukuba
2012-2015
Nippon Veterinary and Life Science University
2011
Andrews University
2011
Glasgow Royal Infirmary
2006-2011
Washington University in St. Louis
2011
Saint Louis University Hospital
2006-2010
Saint Louis University
2005-2010
Discordant alternans has the potential to produce larger of ECG T wave than concordant alternans, but its mechanism is unknown.We demonstrate by one- and two-dimensional simulation action propagation models that discordant can form spontaneously in spatially homogeneous tissue through one two mechanisms, due interaction conduction velocity duration restitution at high pacing frequencies or dispersion diastolic interval produced ectopic foci. In first mechanism, boundaries marking regions...
Abstract The purpose of this study was to determine whether biphasic restitution action potential duration (APD) in ventricular muscle permits the development complex dynamic behavior. Such behavior is expected because steep ascending slope and presence a maximum. Action potentials recorded from strips epicardial which APD occurred demonstrated characteristic pattern phase locking during progressive shortening pacing cycle length. 1:1 replaced by irregular dynamics, turn higher order...
Background — Heart rate turbulence (HRT) is a promising noninvasive risk stratifier for mortality after myocardial infarction. On the basis of study ventricular premature complex coupling interval and sympathetic nerve burst amplitude, we hypothesized that measures HRT would increase with increased prematurity interval. Methods Results Twenty-eight patients undergoing programmed electrical stimulation were studied (12 prior infarction, aged 60±18 years). An extrastimulus was delivered from...
The contribution of cumulative changes in action potential duration (memory) to complex cellular electrophysiological behavior was investigated canine cardiac Purkinje fibers. Complex induced during constant pacing caused by reciprocal interactions between the time full repolarization (TFR), where TFR = response + latency, and diastolic interval (DI). relationship preceding DI differed from that obtained using a standard restitution protocol. In particular, higher-order periodicities chaos...
To test the prognostic value of ventricular late potentials (LPs) in a large cohort post-infarction patients modern reperfusion era.1800 consecutive survivors acute myocardial infarction sinus rhythm and under 76 years age were enrolled. Many (99%) received reperfusion/revascularization therapy (91% percutaneous coronary intervention) up-to-date pharmacological treatment (99% aspirin, 93% beta-blockers, 90% ACE-inhibitors, 85% statins). LPs calculated 968 found to be present 90 (9.3%). The...
Decreasing the slope of dynamic, but not conventional, restitution curves is antifibrillatory. Cardiac memory/accommodation underlies difference. We measured diastolic interval (DI) and action potential duration (APD) in epicardial, endocardial, Purkinje tissue from eight dogs. Consecutive 100-stimulus trains were given to study transitions between basic cycle lengths (BCL) ranging 400 1,300 ms. (DI,APD) pairs aligned immediately on line DI + APD = BCL (64/67) or oscillated (3/67). The...
To assess the association of prolonged QRS duration and late mortality in unselected post-infarction patients revascularization era.A total 1455 survivors acute myocardial infarction (MI) sinus rhythm under 76 years age were enrolled. Ninety eight percent received reperfusion/revascularization therapy (90% percutaneous coronary intervention). After revascularization, (>or=120 ms) was present 87 (6.0%). Additional risk factors studied (>or=65 years), presence diabetes mellitus, history...
1. To determine the cellular electrophysiological mechanisms for unidirectional conduction block and re‐entrant excitation, single cycles of circus movement re‐entry were induced in canine Purkinje fibre‐papillary muscle preparations containing two fibre‐muscle junctions (PMJs). The mounted a partitioned tissue bath that permitted independent superfusion each PMJ. pre‐existing dispersion refractoriness between PMJs was accentuated by superfusing PMJ1 with normal Tyrode solution or 6‐8 mM KCl...
Polythiophene bearing a 2-phenylnaphthalene side group at 3-position was synthesized from 2,5-dibromothiophene monomer by two polymerization methods, i.e., Yamamoto dehalogenative polycondensation using Ni(cod)2 and Ni-catalyzed chain-growth polymerization. Polymers prepared the former method had good solubility for organic solvents, 6300–8400 g mol–1 of number-average molecular weights, absorption bands around 300 385 nm due to π–π* transitions phenylnaphthalene moiety polythiophene...
Aim To evaluate the clinical effects of switching from premixed human insulin to a rapid-acting analogue in type 2 diabetic patients. Research Design and Methods Thirty patients, who were treated with twice-daily injection insulin, enrolled randomized (i) 50/50 lispro at same daily dose as (analogue mix group), or (ii) continued (control group). The doses adjusted every month by registered diabetologists achieve adequate blood glucose levels. At beginning study, again 4 months later, HbA1c...
To prevent end-stage renal disease caused by diabetic kidney disease, we created a predictive model for high-risk patients using machine learning.