A5064236865- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Forensic Toxicology and Drug Analysis
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Regulation of Appetite and Obesity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Circadian rhythm and melatonin
- Pharmacological Effects and Assays
- Sleep and Wakefulness Research
- Pharmacological Receptor Mechanisms and Effects
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Cardiovascular and exercise physiology
- Cardiac electrophysiology and arrhythmias
- Thermoregulation and physiological responses
Saint Louis University
2013-2025
University of Minnesota
2016
Andrews University
2011
Washington University in St. Louis
2011
Glasgow Royal Infirmary
2011
Saint Louis University
2007
Boston Children's Hospital
2005
Heidelberg University
1982-1995
UCLouvain Saint-Louis Brussels
1989-1994
University Medical Center
1990-1991
Efferent renal sympathetic nerves reinnervate the kidney after denervation in animals and humans. Therefore, long-term reduction arterial pressure following drug-resistant hypertensive patients has been attributed to lack of afferent sensory reinnervation. However, reinnervation any organ, including kidney, is an understudied question. we analyzed time course at multiple points (1, 4, 5 days 1, 2, 3, 6, 9, 12 wk) normal Sprague-Dawley rats. Sympathetic innervation innervated contralateral...
Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension; however, the therapeutic mechanisms remain unclear. Efferent renal nerve activity recently been implicated in trafficking inflammatory immune cells and chemokine cytokine release. Several of these mediators are known to activate or sensitize afferent nerves. This study aimed elucidate roles efferent nerves inflammation hypertension deoxycorticosterone acetate (DOCA) salt rat model. Uninephrectomized male...
Cocaine produces a pressor response reportedly resulting from both potentiation of peripheral catecholamine activity and centrally mediated sympathoexcitation. In the present study we sought to differentiate central nervous system contributions hemodynamic effects cocaine. conscious rats, cocaine (5 mg/kg i.v.) produced with two distinct components consisting brief, substantial increase in mean arterial pressure (MAP) associated hindquarters mesenteric vasoconstriction followed by sustained,...
Renal denervation (RDN) has been shown to restore endogenous neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) and reduce sympathetic drive during chronic heart failure (CHF). The purpose of present study was assess contribution afferent renal nerves nNOS-mediated outflow within PVN rats with CHF. CHF induced by ligation left coronary artery. Four weeks after surgery, selective RDN (A-RDN) performed bilateral perivascular application capsaicin on arteries. Seven days...
Abstract Experiments have been conducted to evaluate the effect of neuropeptide Y (NPY) administered at three distinct levels nervous system: (1) posterior hypothalamic nucleus, (2) spinal cord, and (3) vascular noradrenergic neuroeffector junction. It was observed that NPY produced varying cardiovascular effects these sites system. Microinjections into nucleus resulted in an increase blood pressure, which reduced by prior microinjection a muscarinic or H 1 ‐histamine antagonist but not 2...
1. The effect of neuropeptide Y (NPY) on cardiovascular function at three levels the noradrenergic axis where peptide is known to co‐ exist with noradrenaline (NA) and or adrenaline (A) was studied in normotensive Sprague‐Dawley (SD), Wistar‐Kyoto (WKY) spontaneously hypertensive rats (SHR). 2. In perfused mesenteric arterial bed, NPY structurally similar intestinal polypeptide (PYY) decreased periarterial nerve stimulation induced release NA potentiated increase perfusion pressure...
Endothelin is a peptide with potent, long-lasting pressor effects characterized by increases in mesenteric and hindquarters vascular resistance bradycardia following an initial, transient depressor response. This study examined the mechanisms of action endothelin on regional hemodynamics conscious, freely moving rats baroreflex sensitivity both conscious chloralose-anesthetized rats. The response to (0.67 nmol/kg) was attenuated nifedipine (25 micrograms/kg) augmented chloralose anesthesia....
We developed a new method for isolating in situ baroreceptor regions of the rabbit aortic depressor nerve (ADN) and estimated transfer function from pressure to afferent activity frequency range 0.01-5 Hz by white noise technique. Complete isolation area right ADN was made ligation innominate artery subclavian common carotid arteries. altered isolated according binary quasi-white between 80 100 mmHg 12 urethan-anesthetized rabbits. The gain increased two three times as perturbation 0.01 2...
Cocaine or air jet stress evokes pressor responses due to either a large increase in systemic vascular resistance (vascular responders) small increases both cardiac output and (mixed conscious rats. Repeated cocaine administration results elevated arterial pressure responders but not mixed responders. The present study examined the hypothesis that pattern of cardiovascular an unconditioned stimulus (UCS; jet) is related conditioned (CS; tone followed by brief foot shock) individual Our data...
The contribution of adrenergic receptors to the cardiovascular responses cocaine (5 mg/kg i.v.) were examined in conscious, free-moving rats instrumented for continuous measurement arterial pressure, heart rate and blood flows mesentery hindquarters or ascending aorta. Cocaine elicits an immediate (peak) sustained pressor response with a concomitant reduction rate. Prazosin (0.1 pretreatment significantly reduced both peak by attenuating increases systemic, mesenteric vascular resistances....
Cocaine produces apparent myocardial ischemia in some individuals without deleterious effects others. The authors identified a subset of rats which cocaine decrease cardiac output and an increase cardiomyopathies. In the present study, several potential causes this differential responsiveness were examined conscious instrumented for determination by using pulsed Doppler flowmetry. Although arterial pressure heart rate responses to (5 mg/kg i.v.) similar all rats, varied widely. Specifically,...
The anteroventral third ventricle (AV3V) region is necessary for the development of a variety models experimental hypertension. Neuroanatomic studies have identified descending projections from this to mesencephalic central gray and tegmentum. This study was done identify functionally involved in cardiovascular regulation AV3V mesencephalon. Regional hemodynamic responses electrical stimulation were compared with rostral gray, these before after ablation tissue. Stimulation elicited...