A5012664323- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Meningioma and schwannoma management
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Alcoholism and Thiamine Deficiency
- Vascular Malformations Diagnosis and Treatment
- Down syndrome and intellectual disability research
- Neurological diseases and metabolism
- Amyotrophic Lateral Sclerosis Research
- Ion Transport and Channel Regulation
- Cancer, Hypoxia, and Metabolism
- Pain Mechanisms and Treatments
- Cardiovascular and Diving-Related Complications
- Drug-Induced Ocular Toxicity
- Vascular Malformations and Hemangiomas
University of California, San Diego
2018-2025
Saint John's Health Center
2024
LAC+USC Medical Center
2023
University of Southern California
2023
Cedars-Sinai Medical Center
2023
Illinois College
2023
University of California, Irvine
2023
Tripler Army Medical Center
2023
Florida College
2021
University of Florida
2021
Current treatments for chronic pain rely largely on opioids despite their substantial side effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to nociceptive processing. In particular, a hereditary loss-of-function mutation Na
BACKGROUND Rathke cleft cysts (RCCs) are benign sellar/suprasellar lesions that result from mucin-secreting vestigial remnants within the pars intermedia of pituitary gland. When symptomatic, they can present with retro-orbital headaches, visual field defects, and/or dysfunction. OBSERVATIONS A 35-year-old female presented subacute headache, right ptosis, and blurred vision. Workup revealed panhypopituitarism central hypothyroidism adrenal insufficiency. Imaging demonstrated a mass...
To report an interesting case of a massive iris cyst encompassing nearly the entire anterior chamber in adult female years after cataract surgery. A 77-year-old with history bilateral surgery presented large ciliary body mass left eye. The lesion was first incidentally noted one year prior to presentation and continued grow ultimately caused complete obstruction visual axis. Per report, patient received two YAG laser treatments subsequent recrudescence. Exam on second opinion consultation...
Abstract Cerebral amyloid angiopathy (CAA) is a common feature of Alzheimer’s disease in which amyloid-β (Aβ) deposits cerebral and leptomeningeal vessel walls, predisposing vessels to micro- macro-hemorrhages. The walls contain distinct proteins heparan sulfate (HS), yet how vascular HS jointly associate with Aβ unknown. We conducted the first multi-omics study systematically characterize as well abundance, sulfation level, disaccharide composition leptomeninges from 23 moderate severe CAA...
Primary age-related tauopathy (PART) refers to tau neurofibrillary tangles restricted largely the medial temporal lobe in absence of significant beta-amyloid plaques. PART has been associated with cognitive impairment, but contributions from concomitant limbic TDP-43 encephalopathy neuropathologic change (LATE-NC) are underappreciated.
Missense variants of the valosin-containing protein (VCP) gene cause a progressive, autosomal dominant disease termed VCP multisystem proteinopathy (MSP1). The is constellation clinical features including inclusion body myopathy (IBM), Paget bone (PDB), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), typically reported at frequency 90%, 42%, 30%, 9%, respectively. Hispanic population currently underrepresented in previous reports myopathy. We expand our...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated several neurologic manifestations including the development of cerebral lesions resembling CNS vasculitis in elderly patients disease 2019 (COVID-19).1,-,4 Here, we report additional evidence for COVID-19–related vasculitis, confirmed by biopsy, a young healthy patient otherwise mild COVID-19 infection. A 26-year-old woman experienced 4 days anosmia, dysgeusia, malaise, and fatigue 6 after an...
Patients with earlier age at onset of sporadic Alzheimer disease (AD) are more likely than those later to present atypical clinical and cognitive features. We sought determine whether this age-related heterogeneity is mediated by different topographic distributions tau-aggregate neurofibrillary tangles (NFTs) or variable amounts concomitant non-AD neuropathology.
. Purpose To develop and validate a deep learning (DL) method to detect segment enhancing nonenhancing cellular tumor on pre- posttreatment MRI scans of patients with glioblastoma predict overall survival (OS) progression-free (PFS). Materials Methods This retrospective study included 1397 MRIs in 1297 glioblastoma, including an internal cohort 243 (January 2010-June 2022) for model training cross-validation four external test cohorts. Cellular maps were segmented by two radiologists based...
Description Cerebral lymphomatosis (CL) is a rare subtype of primary central nervous system lymphoma (PCNSL). In CL, atypical lymphoid cells diffusely infiltrate the cerebral parenchyma without forming discrete mass as seen with PCNSL. We report case 66-year-old woman diffuse CL and superimposed areas She presented subacute cognitive decline weakness. CSF studies showed lymphocytosis IL-10 elevation. became increasingly somnolent despite steroid intravenous immunoglobulin trials, she...
Background Recently recognized as a distinct entity, myxoid glioneuronal tumor (MGNT) is rare, low-grade central nervous system tumor. MGNTs are commonly located at the septum pellucidum or in third ventricle, increasing likelihood of treatment-related damage to adjacent structures critical for memory, such fornix. Though there have been handful case reports neurosurgical and oncological outcomes MGNTs, memory following resection fornix not previously reported. Methods We present high...
The authors declare that there are no conflicts of interest. peer review history for this article is available at https://publons.com/publon/10.1111/nan.12783.
Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE characterized by neuronal loss, gliosis, and distinctive pattern of accumulation hyper-phosphorylated tau (p-tau) phospho-TDP43 (p-TDP43). Visual anomalies have been reported patients CTE, but the ocular underlying these symptoms unknown. We evaluated retinal post-mortem eyes collected from 8 contact sport athletes brain autopsy-confirmed stage IV...
An adolescent female presented with a several-week history of left-sided vertigo and hearing loss. Neurological examination revealed left peripheral facial nerve vestibulocochlear palsies. MRI demonstrated internal auditory canal (IAC) lesion on fast imaging employing steady-state
Motivation: Differentiating recurrent tumor from post-treatment changes is challenging in post-operative glioblastoma MRI. Goal(s): To compare the performance of DSC-CBV, DSC-CBF, and ASL perfusion MRI to differentiate treatment-related using a Deep Learning segmentation model together with multishell Diffusion Approach: 138 scans were manually segmented for enhancing non-enhancing cellular volume. A was trained segment then tested recurring disease segmentations. Results: DSC-CBV DSC-CBF...
Abstract Background Individuals with Down Syndrome (DS) exhibit a unique aging profile and have early‐onset Alzheimer’s Disease (AD) due to triplication of the amyloid precursor protein (APP) gene on chromosome 21. Method Here, we present study 73‐year‐old non‐Hispanic White female DS who underwent extensive clinical assessments for several decades. She had cognitive functional impairment consistent AD‐like symptoms. Post‐autopsy did neuropathological immunohistochemical analysis brain...
Electron spin resonance (ESR) has been used to study the reorientational motion of bis(maleonitriledithiolato)nickel trianion, [Ni(mnt)(2)](3-), in diethylene glycol dimethyl ether (diglyme). [Ni(mnt)(2)](3-) one unpaired electron and was prepared by reducing dianion, [Ni(mnt)(2)](2-), with potassium metal. The trianion dianion are members redox series [Ni(mnt)(2)](n-) n = 0, 1, 2, 3. monoanion, [Ni(mnt)(2)](-), also S 1/2 its rotational diffusion diglyme subject previous ESR studies. This...
Objective Mobilization of cranial nerve III (CNIII) at its dural entry site is commonly described to avoid damage from stretching during approaches the parasellar, infrachiasmatic, posterior clinoid, and cavernous sinus regions. The histologic relationships CNIII as it traverses dura, associated surgical implications are nonetheless poorly described. We herein assess histology CNIII-dura interface relates mobilization nerve. Methods A fronto-orbitozygomatic temporopolar approach was...
BACKGROUND Thoracic epidural capillary hemangioma is exceedingly rare, with only a few reported cases. The typical presentation usually includes chronic, progressive symptoms of spinal cord compression in middle-aged adults. To the authors’ knowledge, this case first report literature acute traumatic rupture. OBSERVATIONS A 22-year-old male presented worsening lower extremity weakness and paresthesias after fall onto his spine. Imaging showed no evidence fracture but revealed an expanding...