A5054937802- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Fetal and Pediatric Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Brain Metastases and Treatment
- Cancer-related cognitive impairment studies
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Meningioma and schwannoma management
- Neural dynamics and brain function
- Mental Health Research Topics
- Congenital heart defects research
- Cerebrovascular and genetic disorders
University of California, San Diego
2018-2025
San Diego State University
2017-2024
Center for Autism and Related Disorders
2021
Intracortical myelin is thought to play a significant role in the development of neural circuits and functional networks, with consistent evidence atypical network connectivity children autism spectrum disorder (ASD). However, little known about intracortical first years life ASD, during critical neurodevelopmental period when symptoms emerge. Using T1-weighted (T1w) T2w structural magnetic resonance imaging (MRI) 21 young ASD 16 typically developing (TD) children, ages 1.5-5.5 years, we...
Extensive MRI evidence indicates early brain overgrowth in autism spectrum disorders (ASDs). Local gyrification may reflect the distribution and timing of aberrant cortical expansion ASDs. We examined data from (Study 1) 64 individuals with ASD typically developing (TD) controls (7–19 years), 2) an independent sample Autism Brain Imaging Data Exchange (n = 31/group). Gyrification Index (lGI), thickness (CT), surface area (SA) were measured. In Study 1, differences lGI (ASD > TD) found left...
Resting state fMRI (rsfMRI) is frequently used to study brain function, including in clinical populations. Similarity of blood-oxygen-level-dependent (BOLD) fluctuations during rsfMRI between regions thought reflect intrinsic functional connectivity (FC), potentially due history coactivation. To quantify similarity, studies have almost exclusively relied on Pearson correlation, which assumes linearity and can therefore underestimate FC if the hemodynamic response function differs regionally...
Autism postmortem studies have shown various cytoarchitectural anomalies in cortical and limbic areas including increased cell packing density, laminar disorganization, narrowed minicolumns. However, there is little evidence on dendritic axonal organization ASD. Recent imaging techniques the potential for non-invasive, vivo of small-scale structure human brain, gray matter. Here, Restriction Spectrum Imaging (RSI), a multi-shell diffusion-weighted technique, was used to examine matter...
<h3>Objective</h3> To examine changing features of cortical morphology in middle-aged adults with autism spectrum disorders (ASDs) vs typical comparison (TC) participants, hypothesizing regionally decreased local gyrification index (lGI), given our previous findings accelerated lGI decline during adolescence. <h3>Methods</h3> After quality assurance, T1-weighted MRI sequences from 20 participants ASD and 21 TC (40–61 years) matched on age were analyzed. lGI, thickness (CT), surface area (SA)...
Machine learning techniques have been implemented to reveal brain features that distinguish people with autism spectrum disorders (ASDs) from typically developing (TD) peers. However, it remains unknown whether different neuroimaging modalities are equally informative for diagnostic classification. We combined anatomical magnetic resonance imaging (aMRI), diffusion weighted (DWI), and functional connectivity MRI (fcMRI) using conditional random forest (CRF) supervised compare how each...
In vivo myeloarchitectonic mapping based on Magnetic Resonance Imaging (MRI) provides a unique view of gray matter myelin content and offers information complementary to other morphological indices commonly employed in studies autism spectrum disorder (ASD). The current study sought determine if intracortical (MC) its age-related trajectories differ between middle aged older adults with ASD age-matched typical comparison participants.
Abstract Background Patients with primary brain tumors demonstrate heterogeneous patterns of cognitive dysfunction, which we explore using latent profile analysis (LPA) to identify phenotypes and their trajectories in patients receiving radiotherapy (RT). Methods Ninety-six completed neuropsychological testing before post-RT (3, 6, 12-months) on a prospective longitudinal trial, including measures processing speed, executive function, language, verbal visual memory. Models 2-4 classes were...
Individuals with autism spectrum disorder (ASD) show motor impairment into adulthood and risk decline during aging, but little is known about brain changes in aging adults ASD. Few studies of ASD have directly examined the corticospinal tract (CST)-the major descending pathway responsible for voluntary behavior-outside its primary (M1) connections. In 26 middle-aged age-matched typical comparison participants, we used diffusion imaging to examine microstructure volume CST projections from...
Individuals with autism spectrum disorder (ASD) frequently present impairments in motor skills (e.g., limb coordination, handwriting and balance), which are observed across the lifespan but remain largely untreated. Many adults ASD may thus experience adverse outcomes aging, when physical decline naturally occurs. The 'hand knob' of sensorimotor cortex is an area that critical for control fingers hands. However, this region has received little attention research, especially after midlife....
Background Recently recognized as a distinct entity, myxoid glioneuronal tumor (MGNT) is rare, low-grade central nervous system tumor. MGNTs are commonly located at the septum pellucidum or in third ventricle, increasing likelihood of treatment-related damage to adjacent structures critical for memory, such fornix. Though there have been handful case reports neurosurgical and oncological outcomes MGNTs, memory following resection fornix not previously reported. Methods We present high...
Neuroimaging studies of autism spectrum disorder (ASD) have been predominantly unimodal. While many fMRI reported atypical activity patterns for diverse tasks, the MEG literature in ASD remains comparatively small. Our group recently atypically increased event-related theta power individuals with during lexicosemantic processing. The current multimodal study examined relationship between BOLD signal and anatomically-constrained (aMEG) power. Thirty-three adolescents 23 typically developing...
Patients with brain tumors demonstrate heterogeneous patterns of cognitive impairment, likely related to multifactorial etiologies and variable tumor-specific factors. Cognitive phenotyping offers a patient-centered approach parsing heterogeneity by classifying individuals based on impairment. The aim this study was investigate the neuroanatomical associated each phenotype gain better understanding mechanisms underlying impairments.
Abstract Purpose Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for accelerated or early-onset cognitive and neurological decline in ASD. While it well established that brain development children, adolescents young adults with ASD diverges from neurotypical (NT) peers, unknown how function impacted older Understanding age-related changes of crucial to establish best practices health screenings develop interventions...
Abstract Individuals with autism spectrum disorder (ASD) frequently present impairments in motor skills (e.g., limb coordination, handwriting and balance), which are observed across the lifespan but remain largely untreated. Many adults ASD may thus experience adverse outcomes aging, when physical decline naturally occurs. The ‘hand knob’ of sensorimotor cortex is an area that critical for control fingers hands. However, this region has received little attention research, especially after...
Many neurodevelopmental conditions imply absent or severely reduced language capacities at school age. Evidence from functional magnetic resonance imaging is highly limited. We selected a series of five cases scanned with the same fMRI paradigm and aim relating individual profiles onto underlying patterns connectivity (FC) across auditory cortex: three neurogenetic syndromes (Coffin-Siris, Landau-Kleffner, Fragile-X), one idiopathic intellectual disability, autism spectrum disorder (ASD)....
The absence of speech is a clinical phenotype seen across neurodevelopmental syndromes, offering insights for neural language models. We present case bilateral perisylvian polymicrogyria (BPP) and complete with considerable comprehension production difficulties. extensively characterized the auditory perception circuitry by employing multimodal neuroimaging approach. Results showed extensive cortical thickening in motor auditory-language regions. cortex lacked sensitivity to stimuli despite...