A5103043938- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Mitochondrial Function and Pathology
- Pharmacology and Obesity Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism and Genetic Disorders
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA modifications and cancer
- Diet and metabolism studies
- Neurological and metabolic disorders
- Mobile Health and mHealth Applications
- Hormonal Regulation and Hypertension
- Cancer Treatment and Pharmacology
- Lipoproteins and Cardiovascular Health
- Gestational Diabetes Research and Management
- Dialysis and Renal Disease Management
- Fatty Acid Research and Health
- Electrolyte and hormonal disorders
- Non-Invasive Vital Sign Monitoring
Keio University
2016-2025
Saiseikai Central Hospital
2002-2013
Tokyo Dental College
2013
Keio University Hospital
2001
Background: The relationship between the percent coefficient of variation (%CV) and risk severe hypoglycemia (SH) or non-severe (NSH) in patients with type 1 diabetes (T1D) remains to be elucidated. Materials Methods: Effect Intermittent-Scanning Continuous Glucose Monitoring Glycemic Control Including Hypoglycemia Quality Life Patients Type Diabetes Mellitus (ISCHIA) study was a crossover, randomized, controlled trial for prevention T1D using multiple daily injections (MDIs). Blinded...
Type 2 diabetes is a progressive disease and most patients with type eventually need insulin therapy. The objective of this study was to clarify C-peptide immunoreactivity (CPR), marker beta cell function, as predictor requirement for We conducted retrospective 579 consecutive subjects who were admitted our hospital from 2000 2007 able be followed up at least 6 months after discharge. Fasting postprandial serum CPR urinary levels had been measured during admission. Information about therapy...
The vaccine for the coronavirus disease 2019 (COVID-19) has been reported to potentially cause or worsen diabetes. A 73-year-old Japanese woman received two doses of Moderna COVID-19 vaccine. Four weeks after second vaccination, her glycemic control began deteriorate, and 8 patient was diagnosed with new-onset type 1 diabetes that strongly positive autoantibodies showed a disease-susceptible human leukocyte antigen haplotype, DRB1*04:05:01-DQB1*04:01:01. glucagon stimulation test suggested...
It is difficult to distinguish the onset of renal function decline from typical variation in estimated glomerular filtration rate (eGFR) measurements clinical practice. In this study, we used data analysis incorporating smoothing techniques identify significant trends despite large amounts noise. We identified starting points meaningful eGFR based on trajectories. This was a retrospective observational study 2533 type 2 diabetes patients. calculated 1-year rates difference between each value...
The mechanisms of the renoprotective effects sodium-glucose cotransporter 2 inhibitors are unknown. This study aimed to explore effect and mechanism tofogliflozin on urinary albumin by administration, withdrawal, re-administration. Individuals with type diabetes mellitus stage or 3 diabetic nephropathy were enrolled. Tofogliflozin was administered for 24 weeks, withdrawn 12 weeks (withdrawal period), re-administered weeks. primary endpoint change in albumin/creatinine ratio (UACR). secondary...
Abstract Background Increased protein intake has been recommended to prevent sarcopenia/frailty, reports on the quantity and quality of needed associated prognosis, particularly in aging population Asia, are limited. In this study, we aimed investigate relationship between mortality Japanese individuals, aged 85 years older. Methods The data were obtained from Kawasaki Aging Wellbeing Project, which is a prospective cohort study older adults 89 with no physical disability at baseline. Of...
<sec> <title>BACKGROUND</title> In the management of gestational diabetes mellitus (GDM), usual medical treatment requires frequent visits, and this imposes significant physical, psychological economic burdens on pregnant women. </sec> <title>OBJECTIVE</title> To evaluate impact telemedicine quality life costs in patients with GDM. <title>METHODS</title> This single-center, two-arm, randomized, open-label, parallel-group study included GDM who started insulin injection therapy. Participants...
Diabetes is associated with several disorders of the hand, including stenosing flexor tenosynovitis (SFTS). The feature SFTS in diabetics a higher prevalence multiple digit involvement. We examined magnitude tendency for involvement more digits by diabetic patients than nondiabetic patients, and attempted to clarify factors influencing diabetics.The study comprised 302 235 SFTS. total number exhibiting within 1-year period following initial visit Department Orthopaedic Surgery was...
Aims To clarify the efficacy and safety of adding sitagliptin to insulin therapy in Japanese patients with suboptimally controlled type 2 diabetes (T2DM). Study Design Methods This was a 24-week, prospective, randomized, open-labeled, trial. Patients T2DM who were despite receiving at least twice daily injection enrolled study. The randomized continuation treatment (Insulin group) or addition 50 100 mg (Ins+Sita group). primary outcome change HbA1c week 24. Results Adding significantly...
Introduction . It was reported that 25-hydroxyvitamin D level independently associated with anemia in chronic kidney diseases, but the relation between vitamin and diabetes mellitus is not still certain. We analyzed plasma hemoglobin concentration. Materials Methods A cross-sectional study male patients type 2 performed. Correlation coefficients standardized partial regression coefficient for concentration were evaluated. Results Hemoglobin positively correlated body mass index, HbA1c,...
Objectives . We investigated the relationship between stage of diabetic retinopathy and pulse wave velocity (PWV). Methods This was a cross-sectional study 689 patients (406 men 283 women) with type 2 diabetes who were admitted to our hospital from 2004 2007. Brachial-ankle (baPWV) measured by an arterial pressure measurement device as PWV/ABI. Diagnosis made ophthalmologists based on Davis classification: no (NDR), simple (SDR), pre-proliferative (pre-PDR), proliferative (PDR). Results...
There is little information on direct comparison between metformin and glucagon-like peptide-1 (GLP-1) receptor agonists in the Asian population. This study examined efficacy safety of liraglutide monotherapy compared with overweight/obese Japanese patients type 2 diabetes (T2DM). The was a 24-week, open-labeled, randomized controlled study. Overweight or obese T2DM aged 20-75 years suboptimal glycemic control were to monotherapy. primary endpoint change HbA1c at week 24. Secondary endpoints...
Objective The significance of estimated glomerular filtration rate (e-GFR) in diabetic nephropathy has yet to be clearly determined. We therefore compared albuminuria and e-GFR for usefulness predicting progressive decline renal function. Methods A total 1,303 subjects with type 2 diabetes mellitus whose was more than 30 mL/min/1.73 m2 were followed three years. Associations clinical staging based on AER that progression insufficiency (e-GFR <30 m2) evaluated. Results On univariate analysis,...
Introduction. There is no report about risk factors for renal deterioration according to the clinical stage, divided by estimated glomerular filtration rate (eGFR) in type 2 diabetes. Materials and Methods. We evaluated correlated with annual eGFR decline 1303 subjects diabetes whose was ≥30 mL/min/1.73 m(2). strata were defined baseline value as follows: stratum 1: ≥90, 2: ≥60, <90, 3: ≥30, <60. Results. The 2.3 ± 5.4 m(2) overall subjects. Multiple linear regression analysis demonstrated...
Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease subjects type 2 diabetes mellitus. Materials Methods. We evaluated other clinical markers Japanese mellitus (n = 133, 115 men 18 women; age 64.7 ± 11.5 years; HbA1c 8.1 1.6%). Plasma was measured by...
Abstract Glucocorticoid causes hyperglycemia, which is common in patients with or without diabetes. Prolonged hyperglycemia can be experienced even after the discontinuation of glucocorticoid use. In present study, we examined time course blood glucose level hospital who received transient treatment. addition, mechanism prolonged was investigated by using dexamethasone (Dexa)-treated mice and cultured cells. The tolerance tests, insulin glucagon-like peptide 1 (GLP-1), activity dipeptidyl...