A5058273518- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Genital Health and Disease
- AI in cancer detection
- Colorectal Cancer Screening and Detection
- Women's cancer prevention and management
- Colorectal and Anal Carcinomas
- Social Media in Health Education
- Endometrial and Cervical Cancer Treatments
- Reproductive tract infections research
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Vaccine Coverage and Hesitancy
- Mobile Health and mHealth Applications
- Virus-based gene therapy research
- Esophageal Cancer Research and Treatment
- IL-33, ST2, and ILC Pathways
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Porphyrin Metabolism and Disorders
- Bladder and Urothelial Cancer Treatments
- Amino Acid Enzymes and Metabolism
- Cancer and Skin Lesions
- Infectious Diseases and Mycology
- Child Nutrition and Water Access
Hospital de Câncer de Barretos
2015-2024
Hospital São Paulo
2022-2024
Insper
2016-2018
Universidade Federal do Triângulo Mineiro
2006-2007
OBJECTIVE: To evaluate the histologic response rate of high-grade squamous intraepithelial lesions (HSIL) cervix after topical application 5% imiquimod cream. METHODS: In this phase II trial, women with cervical HSIL (cervical neoplasia [CIN] 2–3) were randomly assigned to 250 mg cream applied weekly for 12 weeks, followed by loop electrosurgical excision procedure (LEEP) without preceding treatment. The sample size was calculated based on regression rates previously reported Grimm et al....
Cervical cancer is a public health emergency in low- and middle-income countries where resource limitations hamper standard-of-care prevention strategies. The high-resolution endomicroscope (HRME) low-cost, point-of-care device with which care providers can image the nuclear morphology of cervical lesions. Here, we propose deep learning framework to diagnose intraepithelial neoplasia grade 2 or more severe from HRME images. proposed multi-task convolutional neural network uses segmentation...
The objective of this study was to compare the accuracies double staining for p16/Ki-67 and molecular test high-risk HPV (hr-HPV) identify high-grade cervical intraepithelial neoplasia (CIN2/CIN3) in women with cytology atypical squamous cells undetermined significance (ASC-US) low-grade lesion (LSIL). Data were collected from 201 who underwent screening Barretos Cancer Hospital their results categorized as ASC-US (n=96) or LSIL (n=105). All patients colposcopy without biopsy diagnosis...
Cervical cancer is a leading cause of death in underserved areas Brazil. This prospective randomized trial involved 200 women southern/central Brazil with abnormal Papanicolaou tests. Participants were by geographic cluster and referred for diagnostic evaluation either at mobile van upon its scheduled visit to their local community, or central hospital. both arms underwent colposcopy,
To evaluate the reproducibility and accuracy of HPV16/18-E6 test.The study population was comprised 448 women with a previously abnormal Pap who were referred to Barretos Cancer Hospital (Brazil) for diagnosis treatment. Two cervical samples collected immediately before colposcopy, one hr-HPV-DNA test cytology other using high-affinity monoclonal antibodies (mAb). Women histologic intraepithelial neoplasia grade 2 or 3 considered be positive cases. Different strategies combination screening...
Persistent infection by high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer and its precursor lesions. While some cytokines help immune cells in virus clearance, others contribute to persistence neoplastic progression. Here, levels interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-10, IL-6, IL-4, IL-2 were quantified serum exfoliated (ECCs) patients with HR-HPV, presence IL-6 + was investigated uterine cervix biopsies. Cytokine ECCs 26 HR-HPV...
Cervical cancer (CC) is caused by persistent infection of human papillomavirus high oncogenic risk (hr-HPV); however, several cofactors are important in its carcinogenesis, such as smoking, multiparity, and prolonged use oral hormonal contraceptives (COCs). Worldwide, 16% women COCs, whereas Brazil this rate ∼ 30%. The safety adverse effects COCs widely discussed the literature, including increase carcinogenic risk. Due to existence drugs, combinations, dosages it hard have uniform...
Cervical cancer is the third leading cause of cancer-related death among women in low-to-middle income countries. Pap testing and pathological services are difficult to implement under these settings. Alternative techniques for diagnosis cervical precancer settings needed reduce burden disease. The objective this study was evaluate diagnostic accuracy a low-cost, high-resolution microendoscope imaging system identifying precancerous lesions cervix vivo. A retrospective 59 patients undergoing...
Abstract We conducted a prospective evaluation of the diagnostic performance high‐resolution microendoscopy (HRME) to detect cervical intraepithelial neoplasia (CIN) in women with abnormal screening tests. Study participants underwent colposcopy, HRME and biopsy. The using an automated morphologic image analysis algorithm was compared that colposcopy histopathologic detection CIN as gold standard. To assess potential further improve analysis, we also retrospective assessing multi‐task...
Nearly 90% of cervical cancer cases and deaths occur in low- middle-income countries that lack comprehensive national HPV immunization screening programs. In these settings, it is difficult to implement programs due a infrastructure shortage trained personnel. Screening based on visual inspection with acetic acid (VIA) have been successfully implemented some low-resource settings. However, VIA has poor specificity up patients receiving treatment positive exam are over-treated. A number...
Objective: Early detection and treatment of cervical precancers can prevent disease progression. However, in low-resource communities with a high incidence cancer, equipment costs shortage specialists hinder preventative strategies. This manuscript presents low-cost multiscale vivo optical imaging system coupled computer-aided diagnostic that could enable accurate, real-time diagnosis high-grade precancers. Methods: The combines portable colposcopy high-resolution endomicroscopy (HRME) to...
Patients with AIDS are particularly susceptible to infection intestinal coccidia. In this study the prevalence of infections Cryptosporidium sp and Cystoisospora belli were evaluated among HIV/AIDS patients in Triângulo Mineiro region, Brazil. Between July 1993 June 2003 faecal samples from 359 collected stained by a modified Ziehl-Neelsen method, resulting 19.7% positivity for coccidian (8.6% sp, 10.3% 0.8% both coccidian). diarrhoea T CD4+ lymphocyte levels < 200 cells/mm3 presented...
Objective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained two different collection modalities in a population Brazilian women: self-collection (vaginal lavage) Pap testing. Methods: We enrolled 204 women who were aged 18-64 years had previously abnormal test results; 83.8% them agreed to participate. The sample was divided into aliquots: one for cytological study molecular analysis HPV. Results: Fifty-eight percent participants preferred utilize as...
Human papillomavirus (HPV) DNA testing can be crucial for women who have limited access to traditional screening. The current study compared the results obtained through HPV with those cytology-based screening.A total of 3068 aged 18 85 years were enrolled in an opportunistic cervical cancer screening program developed by Barretos Cancer Hospital and performed a team health professionals working within mobile unit from March December 2012, followed statistical analyses. For each patient, 2...
Cervical cancer remains a leading cause of death among women in low-and middle-income countries. Globally, cervical prevention programs are hampered by lack resources, infrastructure, and personnel. We describe multimodal mobile colposcope (MMC) designed to diagnose precancerous lesions at the point-of-care without need for biopsy. The MMC integrates two complementary imaging systems: 1) commercially available 2) high speed, high-resolution, fiber-optic microendoscope (HRME). Combining these...
Persistent human papillomavirus (HPV) infection is closely associated with cervical carcinoma. Co-infection in the endocervical environment other microorganisms, such as Chlamydia trachomatis, may increase risk of HPV and neoplastic progression. While some individuals, trachomatis resolved activation Th1/IFN-γ-mediated immune response, others develop a chronic marked by Th2-mediated resulting intracellular persistence bacterium increasing infection. This work aimed to quantify cytokines...
Cervical cancer is a significant public health problem, especially in low- and middle-income countries, where women have little access to cervical screening; consequently 80% of related mortality occurs these regions. The development screening methods that need less infrastructure thus represents an urgent medical need. study aims compare the detection rates high-risk human papillomavirus 16 18 E6 oncoprotein urine, vaginal self-collected, scrapes using OncoE6™ Test HPV16 and/or HPV18 with...
The present study aims to establish a risk profile for high-grade cervical lesions and cancer (CIN2 + ) in women undergoing colposcopy at the Hospital do Câncer de Barretos, through analysis of Human Papillomavirus (HPV) infection, cytology, patient's age. Retrospective cross-sectional based on computerized database aged ≥ 18 years old who underwent Prevention Department Barretos from 2017 2019. A total 3,411 were included, 58.0% positive high-risk-HPV test, with higher prevalence CIN2+...
Proflavine is an acridine dye used with high-resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short-term exposure tissue to dilute proflavine may increase cancer risk. We performed a retrospective analysis women referred colposcopy Barretos Cancer Hospital comparing the risk disease progression those whose was (n = 232) or not exposed 160) proflavine. Patients both groups underwent treatment and follow-up based on...
High-risk human papillomavirus (hrHPV) is an essential cause of cervical carcinoma and also strongly related to anal cancer development. The hrHPV E6 oncoprotein plays a major role in carcinogenesis. We aimed evaluate the frequency DNA anuses women with carcinoma. analyzed 117 103 controls for oncogene. Positive test results included 66.7 % hrHPV-16 7.7 hrHPV-18. One case tested positive both HPV variants (0.9 %). samples from canal were HPV-16 59.8 cases. Simultaneous presence cervix was...
The aim of this report is to demonstrate the Barretos Cancer Hospital initiative organizational, laboratorial, and human resources training in implementation an organized cervical screening program low-resource settings.We developed a computational all epidemiological, clinical, laboratorial findings, trace necessary information recruit women for regular or referral complementary exams after liquid-based Pap test analyses.All tests were collected liquid medium 2014 more than 160,000 analyzed...