A5027660207- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Asthma and respiratory diseases
- Immune cells in cancer
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
- Cancer Immunotherapy and Biomarkers
- User Authentication and Security Systems
- Multiple and Secondary Primary Cancers
- Biomedical Research and Pathophysiology
- interferon and immune responses
- Dermatologic Treatments and Research
- Inflammatory mediators and NSAID effects
- Diet and metabolism studies
- Allergic Rhinitis and Sensitization
- Microbial Inactivation Methods
- RNA regulation and disease
- Phytoestrogen effects and research
- Biochemical effects in animals
- Chromatin Remodeling and Cancer
- HIV Research and Treatment
- Lymphoma Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
McGill University Health Centre
2019-2025
Midwestern University
2023-2024
University of South Alabama
2024
Cancer Institute (WIA)
2023
Shree Krishna Hospital
2022-2023
Gandhi Medical College & Hospital
2023
Creative Commons
2023
Pramukhswami Medical College
2022
Palacký University Olomouc
2020
McGill University
2018-2020
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been proposed to be at anatomical barrier sites. Here, we examine regulation IFN-λR1 expression measure downstream effects IFN-λ3 stimulation in human blood cells, compared with lung or liver epithelial cells. directly bound upregulated IFN-stimulated gene...
A deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function CF leads to chronic lung disease. is associated with abnormalities fatty acids, ceramides, and cholesterol, their relationship pathology not completely understood. Therefore, we examined the impact of CFTR on lipid metabolism pro-inflammatory signaling airway epithelium using mass spectrometric, protein array. We observed a striking imbalance acid ceramide metabolism, oxidative stress under basal conditions...
Advanced metastatic colorectal cancer (CRC) with deficient DNA mismatch repair (MMR-d), or immune-hot CRCs, show significantly improved clinical outcomes compared to MMR-proficient (MMR-p), immune-cold CRCs. While the prior represents about 5% of all latter represent 95% and are characterized by low immunogenicity. This study investigates bis-diethyldithiocarbamate (CuET), a novel anticancer compound, its impact on tumor microenvironment (TME). CuET is shown convert immunologically inactive...
The prevalence of obesity and related consequences, including insulin resistance Alzheimer's-like neuropathology, has increased dramatically. Contributing to this is the shift in lifestyle preference away from wholesome foods exercise Western-style diet sedentarism. Despite advances drug development, a healthy regular remain most effective approaches mitigating unwanted sequelae diet-induced on brain health. In study, we used high-fat high-sugar (HFHS) mouse model neurodegeneration examine...
Zona pellucida binding protein 2 (<i>Zpbp2</i>) and ORMDL sphingolipid biosynthesis regulator 3 (<i>Ormdl3</i>), mapped downstream of <i>Zpbp2</i>, were identified as two genes associated with airway hyper-responsiveness (AHR). <i>Ormdl3</i> gene product has been shown to regulate the ceramides. Allergic asthma was be an imbalance between very-long-chain ceramides (VLCCs) long-chain (LCCs). We hypothesized that Fenretinide can prevent allergic asthma–induced augmentation expression,...
Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality. Although the specific etiology unknown, previous research shows that maternal environment may be contributing factor. Gestational stress lead to development NEC by interfering with barrier function intestinal epithelial barrier. The migration cells from crypts tips villi crucial in maintaining integrity Previously, Martin lab found pups psychologically stressed pregnant dams were more susceptible NEC-like...
Cystic fibrosis (CF) is the most common autosomal recessive genetic disease in Caucasians, affecting more than 100,000 individuals worldwide. It caused by pathogenic variants gene encoding CFTR , an anion channel at plasma membrane of epithelial and other cells. Many CF disrupt biosynthesis trafficking or reduce its ion function. The frequent mutation, loss a phenylalanine position 508 (F508del), leads to misfolding, retention endoplasmic reticulum, premature degradation protein....
Abstract Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, contributing to one million deaths yearly. While survival expected in early-stage disease, 5-year rate only 15% metastatic CRC (mCRC). Frequently patients develop resistance their chemotherapy regimens resulting lesions appear lungs, liver, and brain. In recent years, development immunotherapy has become a promising avenue for treatment cold-tumor environments such as CRC. Indeed,...
Abstract Background: Radiofrequency (RF) surgery is an office-based procedure in the treatment of various skin conditions. It has advantage having both cut and coagulation modes, making easy, fast, effective, cheaper, causes minimal collateral thermal damage, resulting rapid healing esthetically pleasant scars. Objective: The present study was a clinical audit done with aim to improve quality practice for RF electrocautery outpatient department (OPD) setup. Materials Methods: This...
Abstract Type III interferons (IFN-lambdas(λ)) are the most recently discovered interferon cytokine family that inhibit viruses by signaling through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, IFN-λs were thought to primarily act on anatomical barrier epithelial cells, neutrophils and subset of dendritic although majority studies have been performed in mice. Here, we examine regulation IFN-λR1 expression downstream effects IFN-λ3 stimulation primary human blood immune cells...
Reticulate acropigmentation of Dohi is a rare genodermatosis inherited as an autosomal dominant trait. It localized form dyschromatosis universalis hereditarian, characterized by the presence hyperpigmented and hypopigmented macules with symmetrical, irregular size shape forming reticulate pattern over dorsa hands feet. Onset normally in first decade but occasionally be delayed. Biopsy not diagnostic helps to rule out its differentials. Dermoscopy new investigative tool which gives specific...