A5011820031- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- Vitamin D Research Studies
- Ion Channels and Receptors
- Bacteriophages and microbial interactions
- Herbal Medicine Research Studies
- Exercise and Physiological Responses
- Ion channel regulation and function
- Poxvirus research and outbreaks
University of Alberta
2018-2023
25-Hydroxyvitamin D (25OHD) is a partial agonist of TRPV1 whereby 25OHD can weakly activate yet antagonize the stimulatory effects full agonists capsaicin and oleoyl dopamine. binds to within same vanilloid binding pocket as capsaicin. inhibits potentiating PKC-mediated activity. reduces T-cell activation trigeminal neuron calcium signalling mediated by These results provide evidence that novel receptor for biological actions vitamin in addition well-documented upon nuclear receptor. The may...
Highly self-reactive T cells are censored from the repertoire by both central and peripheral tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered a major driver tolerance; however, other such as induction regulatory functional impairment have been described. An understanding interplay between these different still lacking. We previously showed that impaired clonal to model tissue-restricted Ag did not compromise tolerance. In this study, we determined...
Abstract Vaccinia virus (VACV) is a double-stranded DNA that devotes large portion of its 200 kbp genome to suppressing and manipulating the immune response host. Here, we investigated how targeted removal immunomodulatory genes from VACV impacted cells in tumor microenvironment with intention improving therapeutic efficacy breast cancer. We performed head-to-head comparison six mutant oncolytic VACVs, each harboring deletions modulate different cellular pathways, such as nucleotide...
Several unique waves of γδ T cells are generated solely in the fetal/neonatal thymus, whereas additional cell subsets adults. One intriguing feature development is coordination differentiation and acquisition effector function within fetal thymus; however, it less clear whether this paradigm holds true adult animals. In study, we investigated relationship between maturation thymic export adult-derived thymocytes mice. Rag2pGFP model, immature (CD24+) expressed high levels GFP only a minority...
The autoimmune disease of type 1 diabetes (T1D) results in the immune destruction β-cells. Recent studies suggest supplementation vitamin D along can significantly improve patients’ β-cell function and glycemic control possibly by dampening naïve T-cell activation. However, underlying cellular mechanism for this effect has not been elucidated completely, especially as T-cells possess absent or very low VDR expression. Therefore, effects Vitamin on may involve a VDR-independent pathway....
Abstract Highly self-reactive T cells are censored from the repertoire by both central and peripheral tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered a major driver tolerance; however, other such as induction regulatory functional impairment have been described. An understanding interplay between these different still lacking. We previously showed that impaired clonal to model tissue-restricted antigen (TRA) did not compromise tolerance. In this...
<div>Abstract<p>Vaccinia virus (VACV) is a double-stranded DNA that devotes large portion of its 200 kbp genome to suppressing and manipulating the immune response host. Here, we investigated how targeted removal immunomodulatory genes from VACV impacted cells in tumor microenvironment with intention improving therapeutic efficacy breast cancer. We performed head-to-head comparison six mutant oncolytic VACVs, each harboring deletions modulate different cellular pathways, such as...
<p>Supplemental tables 1-2 and supplemental figures 1-7</p>
<p>Supplemental tables 1-2 and supplemental figures 1-7</p>
<div>Abstract<p>Vaccinia virus (VACV) is a double-stranded DNA that devotes large portion of its 200 kbp genome to suppressing and manipulating the immune response host. Here, we investigated how targeted removal immunomodulatory genes from VACV impacted cells in tumor microenvironment with intention improving therapeutic efficacy breast cancer. We performed head-to-head comparison six mutant oncolytic VACVs, each harboring deletions modulate different cellular pathways, such as...