A5067591148- Planarian Biology and Electrostimulation
- Cancer Research and Treatments
- Wound Healing and Treatments
- Reproductive System and Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Migraine and Headache Studies
- Birth, Development, and Health
- Laser Applications in Dentistry and Medicine
- Reproductive Biology and Fertility
- Neuroscience and Neural Engineering
- Mesenchymal stem cell research
- Circadian rhythm and melatonin
- Renal cell carcinoma treatment
- Reproductive tract infections research
- Single-cell and spatial transcriptomics
- Genomic variations and chromosomal abnormalities
- Digestive system and related health
- Plant and Biological Electrophysiology Studies
- Gynecological conditions and treatments
- Genetics and Neurodevelopmental Disorders
- Immune Cell Function and Interaction
Washington University in St. Louis
2024-2025
Université Laval
2019-2023
Shahid Beheshti University of Medical Sciences
2015-2020
This study evaluated the effect of low (20 and 40 mV/mm) intensities electrical stimulation on proliferation migration skin fibroblasts from diabetic donors. We also examined modulating capacity to contract collagen gel, express alpha-smooth muscle actin, secrete proteolytic enzymes involved in regulating extracellular matrix synthesis degradation. Our shows that 20 mV/mm increased growth extracted patients but not non-diabetic Electrical fibroblasts, their expression actin promoted...
There is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 samples 68 mice at developmental adult time points, creating molecular atlas mouse across lifespan for both sexes. We show that proximal tubules have most sex-biased differentially expressed genes emerging after 3 weeks age are associated with hormonal regulations. reveal potential mechanisms involving direct...
Lactobacilli are a group of beneficial bacteria whose anti cancer effects have been evaluated in different cell lines as well animal models and human subjects. Such can be exerted via mechanisms such modulation immune response inhibition pathogens colonization. In addition, lactobacilli direct cytotoxic against cells which may through expression related pathways.The aim this study is to find the mechanism two strains, Lactobacillus. crispatus (LC) rhamnosus (LR).We analyzed some mTOR Wnt/...
Effective wound healing remains a significant clinical challenge in reducing patient morbidity and improving quality of life. Wound is complex process involving the endogenous electrical field. The field can contribute to by activating keratinocytes promote reepithelialization. objective this study was determine effects exogenous stimulation (ES) on human keratinocyte viability proliferation production IL-6, IL-8, keratins (K5 K14) investigate activated signalling pathways exposed ES....
Diabetic foot ulcers are indicative of an impaired wound healing process. This delay may be resolved through electrical stimulation (ES). The goal the present study was to evaluate effect ES on diabetic fibroblast adhesion and growth, secretion cytokines growth factors. human skin fibroblasts (DHSF) were exposed various intensities direct current (100, 80, 40 20 mV/mm). evaluated using Hoechst staining, MTT trypan blue exclusion assays. cytokine factor assessed by array ELISA assay....
Hypoxia-Inducible Factor (HIF)-1 plays an essential role in the body's response to low oxygen concentrations and regulates expression of several genes implicated homeostasis, vascularization, anaerobic metabolism as well immunological responses. Increased levels HIF-1α are associated with increased proliferation more aggressive breast tumor development. Lactobacilli have been shown exert anti-cancer effects on malignancies including cancer. However, exact mechanism such effect is not clear...
Context: Ovarian cancer is the most fatal gynecological malignancy with no effective screening strategy for early detection. As cases are being detected in advance stages, conventional therapies not beneficial majority of patients. Cancer-testis antigens (CTAs) a group tumor associated specific expression pattern cancers which potentiate them application as biomarkers and targets immunotherapy. Evidence Acquisition: We performed computerized search MEDLINE/PUBMED databases key words: ovarian...
Background: Preeclampsia is a hypertensive disorder that affects pregnancy, mother, and fetus. Pathogenesis of preeclampsia could be associated with the angiogenesis pathways. The vascular endothelial growth factor (VEGF) family one important factors for normal pregnancy angiogenesis. Genetic variations in gene members may play role etiology preeclampsia. We investigated possible association between VEGFA rs3025039, VEGFR1 (FLT1) rs722503 polymorphisms sample Iranian patients. Methods:...
Uterine leiomyomas (ULMs) are benign uterine tumors that estrogen-dependent. Recent studies suggest the abnormal expression of steroid receptor RNA activator 1 (SRA1) long non-coding (lncRNA) might participate in mechanisms tumorigenesis some hormone-dependent including breast cancer. SRA1 is known to enhance transcriptional activity receptors and also promotes steroidogenesis. The level hormones, such as estrogen progesterone, their play an important role development growth leiomyoma. aim...
Abstract Aims RAR‐related orphan receptor ( RORA ) involves in regulation of several biological processes including inflammation and circadian rhythm that probably are involved migraine pathophysiology. In the current study, association between rs11639084 rs4774388 variants susceptibility to were investigated a sample Iranian patients for first time. Methods case‐control study 400 participants, 200 migraineurs healthy controls, genotyping polymorphisms was performed using tetra‐primer...
The prevalence of diabetes is increasing worldwide. Diabetes contributes to 70% all non-traumatic lower-limb amputations, which are directly caused by diabetic foot ulcers (DFU) that difficult heal. Non-healing represent one modern society's most medical challenges. One the promising initiatives treat DFU grafting autologous skin or stimulating cells at edge wound proliferate and close wound. present study was engineer a human equivalent (DHSE) contains fibroblasts keratinocytes extracted...
Background: Cancer testis antigens (CTAs) are considered cancer bio markers due to their highly specific expression pattern in human malignancies and near absence from normal somatic tissues.Their has made them potential targets for early dia gnosis, assessment of patients' prognosis treatment recent years.Lactobacilli a group probio tics with anti-cancer, immunomodulatory other beneficial features.These bacteria have been shown alter several cancer-related genes.Aim: We investigated the...
Abstract BAP1 mutations are associated with increased T cell and tumor-associated macrophage infiltration in clear renal carcinoma (ccRCC) predictive of poor prognosis. have also been found to be T-cell peritoneal mesothelioma uveal melanoma. Because known aggressive disease survival, we hypothesize that these lead a more immunosuppressive microenvironment. Using single nucleus RNA sequencing high-resolution spatial transcriptomics, confirmed mutant tumors immune hot high fraction Treg,...