A5043420575- Metabolism, Diabetes, and Cancer
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Diabetes Treatment and Management
- Transgenic Plants and Applications
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- SARS-CoV-2 and COVID-19 Research
- Curcumin's Biomedical Applications
- Phytochemical compounds biological activities
- Microbial Inactivation Methods
- Peptidase Inhibition and Analysis
- vaccines and immunoinformatics approaches
- Blood Coagulation and Thrombosis Mechanisms
- Pancreatic function and diabetes
- Synthesis and biological activity
- Advanced Drug Delivery Systems
- Estrogen and related hormone effects
- Protease and Inhibitor Mechanisms
- Kruppel-like factors research
- Bacillus and Francisella bacterial research
- Synthesis and bioactivity of alkaloids
- Advancements in Transdermal Drug Delivery
- Nanocomposite Films for Food Packaging
Iran University of Medical Sciences
2017-2024
Tehran University of Medical Sciences
2015
X-ray computed tomography (CT) requires an optimal compromise between image quality and patient dose. While high is important requirement in CT, the radiation dose must be kept minimal to protect patients from ionizing radiation-associated risks. The use of probes based on gold nanoparticles (AuNPs) along with active targeting ligands for specific recognition cancer cells may one balanced solutions. Herein, we report effect folic acid (FA)-modified AuNP as a targeted nanoprobe contrast...
Side effects and chemotherapy resistance, demand new therapeutics with minimal side effects. Here, we investigated the combined effect of curcumin metformin on LNCaP prostate cancer cell line. cells were treated curcumin, metformin, their combination at different concentrations. Cell viability was assessed by MTT assay expression Bax, Bcl-2, mTOR, hTERT, PUMA, p53 p21 genes analyzed real-time PCR. Apoptosis cycle flow cytometry. Our results revealed that significantly (P < 0.05) reduced...
Breast cancer is the most common in women; it has been affecting lives of millions each year globally and microfluidic devices seem to be a promising method for future advancements this field. This research uses dynamic cell culture condition concentration gradient device, helping us assess breast anticancer activities probiotic strains against MCF-7 cells. It shown that cells could grow proliferate at least 24 h; however, specific supernatant induce more death signaling population after 48...
Paliurus spina-christi Mill. (PSC) fruit is frequently used in the treatment of diabetes mellitus Mediterranean regions. Here, we investigated effects various PSC extracts (PSC-FEs) on glucose consumption and some key mediators insulin signaling pathways high insulin-induced insulin-resistant HepG2 cells.The methanolic, chloroform total cell proliferation were assessed by MTT assay. The potential non-toxic utilization cells was checked using a oxidase AKT AMP-activated protein kinase (AMPK)...
Glucagon-like petide-1 (GLP-1) agonists such as liraglutide are widely employed in type 2 diabetes due to their glucose reducing properties and small risk of hypoglycemia. Recently, it has been shown that GLP-1agonists can inhibit breast cancer cells growth. Nonetheless, concerns remained about tumor promoting effects stated by population studies.We evaluated the on proliferation MDA-MB-231 MTT assay then ATP-binding cassette (ABC) transporters expressions assessed Real time PCR. Statistical...
Abstract Cell invasion is an important process in cancer progression and recurrence. Invasion implantation of cells from their original place to other tissues, by disabling vital organs, challenges the treatment patients. Given importance matter, many molecular treatments have been developed inhibit cell invasion. Because low production cost ease production, peptides are valuable therapeutic molecules for inhibiting In recent years, advances field computational biology facilitated design...
Tamoxifen (TAM), the most widely used anti-estrogenic drug, inhibits progression of breast cancer through competing with estrogen for binding to receptor (ER). has been first-line adjuvant endocrine therapy in pre- and postmenopausal patients ER + two decades. However, due its side effects, interest using anticancer agents derived from natural foods increased. It recently stated that some probiotics can improve efficacy drugs via synergistic effects. Here, Local Probiotic Lactobacillus...
Immunotoxin targeted therapy is a promising way of cancer that made from toxin attached to an antibody which target specific protein presented on cells. In this study, we introduce immunotoxins comprising truncated pseudomonas exotoxin A (PEA) and diphtheria (DT) conjugated trastuzumab. The effectiveness 20 30 μg/ml trastuzumab were studied SK-BR-3 BT-474 HER2/neu positive breast cell lines by death assay test. produced have the potential reduce therapeutic dose in same time achieve higher...
Local probiotic Lactobacillus brevis downregulates LPAR1 and LPAR2 gene expression reduces invasion of MDA-MB-231 MCF-7 breast cancer cell lines