A5033489378- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Organic Compounds
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Neuroscience and Neuropharmacology Research
- Synthesis of β-Lactam Compounds
- Estrogen and related hormone effects
- Carbohydrate Chemistry and Synthesis
- Quinazolinone synthesis and applications
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Biochemical effects in animals
- Nicotinic Acetylcholine Receptors Study
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Reactivity of Heterocycles
- Neurotransmitter Receptor Influence on Behavior
- Research on Leishmaniasis Studies
Tehran University of Medical Sciences
2016-2025
University of Illinois Urbana-Champaign
2016
University of Tehran
2004-2008
University of Waterloo
2005-2006
The essential oil of Nepeta menthoides Boiss. & Bohse., from Iran, was analysed by GC/MS. Two types multivariate analyses were done based on the chemical composition investigated sample in this study and 12 other samples reported literature to show chemodiversity composition. Antimicrobial, acetylcholinesterase inhibitory cytotoxic activities its major component assessed. Twenty-one compounds identified, representing 96.81% total constituent 1,8-cineole (70.06%). Multivariate revealed two...
A green, simple, and stability-indicating RP-HPLC method was developed for the determination of diltiazem in topical preparations. The separation based on a C18 analytical column using mobile phase consisted ethanol: phosphoric acid solution (pH = 2.5) (35 : 65, v/v). Column temperature set at 50°C quantitation achieved with UV detection 240 nm. In forced degradation studies, drug subjected to oxidation, hydrolysis, photolysis, heat. validated specificity, selectivity, linearity, precision,...
Abstract A series of 2‐phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic anti‐inflammatory activities. Several compounds having an unsubstituted phenyl/4‐pyridyl or C‐4 methoxy substituent on the terminal phenyl ring showed moderate to high activity in comparison mefenamic as reference drug. The with highest subjected vitro COX‐1/COX‐2 inhibition assays good COX‐1 weak COX‐2
Amyloids are protein fibrils of nanometer size resulting from self-assembly. They have been shown to be associated with a wide variety diseases such as Alzheimer's and Parkinson's may contribute various other pathological conditions, known amyloidoses. Insulin is prone form amyloid under slightly destabilizing conditions in vitro structures when subcutaneously injected into patients diabetes. There great deal interest developing novel small molecule inhibitors amyloidogenic processes,...
A group of cycloalkyl and aryl ester analogues nifedipine (CAS 21829-25-4), in which the ortho-nitrophenyl at position 4 is replaced by a 2-phenyl-4(5)-im-idazolyl substituent, were synthesized evaluated as calcium channel antagonist using high K<sup>+</sup> contraction guinea-pig ileal smooth muscle. The results for symmetrical esters showed that increasing length methylene chain C3 C5 substituents (from n = 0 to 3) increased activity. comparison effect cyclohexyl relative phenyl...