A5009008659- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Natural Antidiabetic Agents Studies
- Nanocomposite Films for Food Packaging
- Curcumin's Biomedical Applications
- Ocular Surface and Contact Lens
- Phytochemicals and Antioxidant Activities
- Analytical Methods in Pharmaceuticals
- Bee Products Chemical Analysis
- Retinoids in leukemia and cellular processes
- Liver Disease Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Electrohydrodynamics and Fluid Dynamics
- Gastrointestinal motility and disorders
- Advanced Glycation End Products research
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
- Essential Oils and Antimicrobial Activity
- Polysaccharides Composition and Applications
- Anesthesia and Pain Management
- Glaucoma and retinal disorders
Ahvaz Jundishapur University of Medical Sciences
2015-2024
The aim of this study was to develop and characterize 5-Fluorouracil (5FU) containing targeted liposomes in order enhance the efficacy safety drug. Folic acid (FA) used as a targeting ligand. vitro cytotoxicity formulation against HT-29, Caco-2, CT26, HeLa MCF-7 cell lines evaluated using MTT assay. Mechanism death induced by further investigated via production reactive oxygen species (ROS), change mitochondrial membrane potential (ΔΨm), release cytochrome c activity caspase 3/7. vivo tumor...
Type 2 diabetes mellitus (T2DM) may occur via oxidative stress. Myricitrin is a plant-derived antioxidant, and its solid lipid nanoparticle (SLN) be more potent. Hence, the present study was conducted to evaluate effects of myricitrin SLN on streptozotocin-nicotinamide- (STZ-NA-) induced T2DM mouse hyperglycemic myotube. In this experimental study, cold homogenization method used prepare SLN. Then, 120 adult male NMRI mice were divided into 7 groups: control, vehicle, (received STZ 65 mg/kg...
Implication for health policy/practice/research/medical education: Development of polymeric in situ gels controlled release various drugs provides a number advantages over conventional dosage forms.Some important these smart systems are ease application and reduced frequency administration, as well protection the drug from environmental conditions.
Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. The availability effective therapeutic options for management CKD-associated remains treatment challenge.The aim this study was to compare cromolyn sodium cream 4% with placebo the renal pruritus.A randomized, double-blind, prospective, 4-week designed. 60 ESRD in our dialysis ward were randomly allocated or placebo. All them completed period and their...
Hyperglycemia induced oxidative stress inside the cells. Myricitrin, as an antioxidant plant-derived component, may be useful in hyperglycemia. Hence, aim of this study was conducted to evaluate effects myricitrin on hyperglycemia-induced damage myotubes (C2C12 cells). In experimental study, mouse myoblast cell line (C2C12) obtained and divided into five groups: control, hyperglycemia, hyperglycemia + 1, 3, 10 μM. After treatment period for 48 h, cells were collected, homogenized,...
The aim of this study was to design and evaluate a chitosan-based film that has properties required for successful wound dressing, can control drug penetration maintenance time in the location. Several formulations containing chitosan (3%) different concentrations Eudragit RL (0.5%, 1%, 1.5%) were prepared using casting/solvent evaporating technique. Mechanical properties, water vapor transmission rate (WVTR), oxygen permeability, uptake, nitrofurazone permeability through films...
Importance: To reduce the frequency of dorzolamide eye drop administration and increasing duration action.Background: This study aims to compare effect loaded-nanoliposome with marketed HCl on intraocular pressure in primary open angle glaucoma ocular hypertension patients.Design: A randomized was conducted a hospital.Participants: Twenty patients or (in both eyes) diagnosis were recruited as participants.Methods: Dorzolamide prepared by thin layer hydration method characterized. Intra...
Griseofulvin is an antifungal drug and available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections the skin. In this study, films prepared from incorporation griseofulvin-loaded liposomes in chitosan film delivery infections. The properties were characterized regarding mechanical properties, swelling, ability to transmit vapor, release, thermal behavior, efficacy against Microsporum gypseum Epidermophyton floccosum. presence led...
Background: Chitosan-based nanoparticle systems have gained wide interest, mainly for their biocompatibility, biodegradability and mucoadhesive properties. Objectives: The aim of this study was to prepare evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. Materials Methods: Chitosan (CS) containing diclofenac prepared using Sodium tripolyphosphate (TPP) used as a polyanion in process. effect some parameters particle size drug loading efficiency...
The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice.In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicle, diabetes, diabetes + 1, 3, 10 mg/kg and, SLN containing mg/kg. After period, plasma tissue samples collected for experimental, histopathological, real-time PCR apoptosis assessments.Total antioxidant...