The present study investigates the antioxidant and hepatoprotective effects of

Acrylamide (ACR) is an environmental contaminant and a well-known neurotoxin. Ellagic acid (EA), natural plant polyphenol, has shown variety of beneficial effects. The present study was designed to explore whether EA could attenuate ACR-induced neurotoxicity in rats the underlying mechanisms. Animals were divided into five groups. Group 1 treated with normal saline (2 mL/kg) for 30 days. 2 ACR (20 mg/kg, orally) Groups 3 4 (10 5 (30 Open field, rotarod passive avoidance test conducted...

In multiple studies, involvement of oxidative stress in the pathogenesis methotrexate (MTX)-mediated liver damage has been confirmed. Use many drugs examined experimentally order to prevent or diminish stress. However, no study yet effects ferulic acid (FA) on MTX-induced damage. This aimed at evaluating FA protection against induced by MTX mice.In this mice were divided into five groups a random manner: I) control; II) (20 mg/kg); III and IV) (50 100 mg/kg) + MTX; V) (100 mg/kg), we...

The major side effect of gentamicin (GEN) is nephrotoxicity which in turn restricts the clinical use this drug. In study, gallic acid (GA) on gentamicin-induced was studied. A total number 28 male Wistar rats were randomly divided into four experimental groups: control, GEN (100 mg/kg/day), + GA (30 mg/kg/day). All drug administrations done intraperitoneally (i.p) for eight consecutive days. Twenty-four hours after last administration, blood samples collected to determine serum creatinine...

Bisphenol A (BPA), which is an applied endocrine disrupting chemical in industry for producing epoxy resins and polycarbonate plastics naringin, active flavanone glycoside of grapefruit many citrus fruits. The present study evaluated the protective effect naringin against cardiotoxicity induced by BPA. Male Wistar rats were divided into six groups. Control group received oral olive oil; BPA orally administrated 50 mg/kg 30 d consecutively to induce toxicity. 40, 80, 160 administered...

The present study was designed to investigate the changes in rat liver tissue after administration of acrylamide (ACR) and ellagic acid (EA). latter compound applied for its strong antioxidant anti-inflammatory properties. In study, 35 male Wistar rats were randomly divided into five equal groups. These groups normal saline (NS), ACR (20 mg/kg), + EA (10 30 mg/kg EA), (30 mg/kg). At end experiment, decapitated. Biochemical histopathological studies conducted on serum samples. significantly...

Context: Oxidative stress and mitochondrial dysfunction are thought to be the main mechanism of T-2 toxin toxicity. is most potent trichothecene mycotoxin which present in agricultural products. L-carnitine, besides its anti-oxidative properties, facilitates transportation long-chain fatty acids matrix. Objective: In this study we tested whether an antioxidant a facilitator for acid across membranes, could protect rat hepatocytes against toxicity induced by toxin. Materials methods:...

Abstract In this study, combinations of Ginkgo biloba leaf extract (EGb761) plus the carotenoid antioxidant astaxanthin (ASX) and vitamin C were evaluated for a summative dose effect in inhibition asthma‐associated inflammation asthmatic guinea‐pigs. Ovalbumin‐sensitized Hartley guinea‐pigs challenged with ovalbumin aerosol to induce asthma, administered EGb761, ASX, or ibuprofen. Following killing, bronchoalveolar lavage (BAL) fluid was inflammatory cell infiltrates lung tissue cyclic...

Glyoxal is a physiological metabolite formed by lipid peroxidation, ascorbate autoxidation, oxidative degradation of glucose, and glycated proteins. has been linked to stress can cause number cellular damages, including covalent modification amino thiol groups proteins form advanced glycation end products. However, the mechanism glyoxal toxicity not fully understood. In this study, we have focused on in isolated rat liver mitochondria. Isolated mitochondria (0.5 mg protein per milliliter)...

Overdose of acetaminophen (APAP) is the main reason for acute liver failure. Oxidative stress associated with hepatotoxicity caused by APAP. Betaine a methyl donor and S-adenosylmethionine precursor. The present study investigated effect betaine role nuclear factor-erythroid-2-related factor 2 (Nrf2) heme oxygenase-1 (HO-1) genes in induced APAP mice. In this study, male Naval Medical Research Institute (NMRI) mice were treated 500 mg/kg 5 days followed single dose 300 on fifth day....

Due to the fact that methotrexate is widely used both as an immunosuppressive drug and a chemotherapy agent, many studies are needed reduce side effects of this on non-target organs.This study was designed investigate epicatechin (Epi) MTX (methotrexate)-induced hepatotoxicity in mice.After 1 week for adaptation, we randomly divided 42 male Naval Medical Research Institute mice into six groups: (I) control; (II) Epi (100 mg/kg, po); (III) (20 i.p.) fifth day; (IV, V, VI) (25, 50, 100 po) +...

In the present study, hepatoprotective effect of Cassia fistula fruit extract was investigated in mice. Animals were divided into six groups receiving normal saline (1), bromobenzene (460 mg/kg) alone (2) and together with increasing doses (200, 400, 600, 800 a crude hydro-alcoholic (3-6, respectively). All administrations carried out orally, daily, for 10 days. On 11th day, animals sacrificed. Serum activities aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP) gamma...

The present report describes outcomes of animal studies conducted to determine the systemic and dermal toxicity Prunus cerasus (sour cherry) seed kernel contents; a separate evaluation photoprotective capacity oil fraction. B6 mice Hartley guinea-pigs were used for these experiments. Dosage groups 6-8 animals administered whole meal in dose range 0-3000 mg/kg by gavage 8 days, following which they killed. liver kidney weights recorded histological examination performed on sections organs....

Background: Hepatotoxicity is one of the most life-threatening side-effects Methotrexate therapy. Former studies highlighted significance oxidative stress in promoting Methotrexate-induced hepatotoxicity (MIH). Hence, current study investigated protective effect Ellagic acid (EA), a poly-phenolic antioxidant, against MIH.Methods: Twenty-eight male Wistar rats were grouped into four sets: group 1 (control), 2 (injected intraperitoneally with 20 mg/kg on 9th day), 3 (treated orally 10...

Cyclophosphamide (CP) as an alkylating compound has been widely applied to treat cancer and autoimmune diseases. CP is observed be nephrotoxic in humans animals because it produces reactive oxygen species. Gallic Acid (GA), a polyhydroxy phenolic compound, reported exhibit antioxidant anti-inflammatory effects.The current research aimed at evaluating the GA effect on CP-related renal toxicity.In total, 35 male mice were assigned 5 groups. Group1: receiving normal saline, group 2: group, one...

Single-walled carbon nanotubes (SWCNTs) and multiwalled (MWCNTs) are broadly applicable across a variety of industrial fields. Despite their usefulness in many different applications, oxidative stress-induced toxicity SWCNTs MWCNTs has not been widely investigated. The present study examined the effects on rat brain mitochondria using 3,4 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay indices reactive oxygen species (ROS), based measurements malondialdehyde (MDA),...