A5035782018- Natural Antidiabetic Agents Studies
- Chemotherapy-induced organ toxicity mitigation
- Wound Healing and Treatments
- Arsenic contamination and mitigation
- Phytochemicals and Antioxidant Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obsessive-Compulsive Spectrum Disorders
- Saffron Plant Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Medicinal Plants
- Drug Transport and Resistance Mechanisms
- Ginger and Zingiberaceae research
- Natural Products and Biological Research
- Complementary and Alternative Medicine Studies
- Diverse Scientific Research Studies
- Analytical Methods in Pharmaceuticals
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Metabolism, Diabetes, and Cancer
- Chemical synthesis and alkaloids
- Surgical Sutures and Adhesives
- Heavy Metal Exposure and Toxicity
- Medicinal plant effects and applications
- Date Palm Research Studies
- Antioxidants, Aging, Portulaca oleracea
- Plant chemical constituents analysis
Ahvaz Jundishapur University of Medical Sciences
2012-2024
Abstract Objective To assess the efficacy and tolerability of ondansetron in combination with selective serotonin reuptake inhibitors (SSRIs) patients obsessive‐compulsive disorder (OCD). Methods The study was an 8‐week pilot double‐blind randomized clinical trial. Forty‐two adult outpatients who met Diagnostic Statistical Manual, Fourth Edition, Text Revision (DSM‐IV‐TR) criteria for OCD based on structured interview participated In this study, were randomly assigned to receive either (4...
The present study aimed to investigate the protective effects of two potent natural antioxidants, gallic acid and quercetin as single or combination treatment against bleomycin-induced pulmonary fibrosis (PF). A total 50 Wistar rats were randomly divided into 5 groups. Group 1 2 intratracheally received saline bleomycin (7.5 UI/kg), respectively, on day 7, accompanied by oral administration for 28 day. Groups 3, 4, a dose acid, quercetin, their combination, Finally, lungs removed biochemical...
Hepatotoxicity is an adverse side effect of methotrexate (MTX) administration for the treatment different malignancies, psoriasis, and rheumatoid arthritis (RA). Naringenin (NAR) a citrus flavone with multiple pharmacological characteristics. In this study, we aimed to investigate protective effects NAR on MTX-induced hepatotoxicity in rats. For purpose, 32 Wistar rats were randomly divided into four experimental groups as group 1 Control, 2 (50 mg/kg/d, o.p.), 3 MTX (20 i.p.), 4 + MTX. was...
Background: Hepatotoxicity is one of the most life-threatening side-effects Methotrexate therapy. Former studies highlighted significance oxidative stress in promoting Methotrexate-induced hepatotoxicity (MIH). Hence, current study investigated protective effect Ellagic acid (EA), a poly-phenolic antioxidant, against MIH.Methods: Twenty-eight male Wistar rats were grouped into four sets: group 1 (control), 2 (injected intraperitoneally with 20 mg/kg on 9th day), 3 (treated orally 10...
Background: Pulmonary fibrosis is a deadly and destructive disease. Various chemicals, drugs, environmental factors are responsible for pulmonary fibrosis. The disease can also be idiopathic. A number of inflammatory mediators cytokines, such as interleukin-13 (IL-13), platelet‐derived growth factor (PDGF), tumor necrosis α (TNF-α), play an important role in Profibrotic cytokines accelerate the maturation proliferation fibroblasts, which ultimately increases amount collagen deposits alveolar...
Type 2 diabetes mellitus (T2DM) is the most common type of diabetes. A decrease in number pancreatic beta cells a pathological sign diabetes, and to date there no drug treatment that targets damage these cells. Pancreatic have weak antioxidant system are highly sensitive oxidative stress reactions occur within Thioredoxin interacting protein (TXNIP) inhibits thioredoxin, which part intracellular system, thereby accelerating apoptosis Verapamil non-dihydropyridine calcium channel blocker. The...
Traditionally Rheum ribes L. has been used in Iran as sedative and mood enhancer. This study investigated the efficacy safety of a hydroalcholic extract of R. ribes in treatment mild to moderate major depression disorder 33 patients were randomly assigned receive either Rheum ribes hydroalcoholic (1200 mg/day) or placebo 6-week, double blind parallel-group trial. Patients assessed before during weeks 1, 2, 4 6 by Hamilton Rating Scale for Depression (HAM-D) score sheet on adverse effects. In...
Objective: Regarding the unfavorable side effects of anti-diabetic drugs including peripheral edema, gastrointestinal discomfort and hypoglycemia, using medicinal plants due to their useful contents such as flavonoids, alkaloids, glycopeptides, terpenoides, phenolic compounds other constituents with antioxidant anti-inflammatory effects, is encouraged in treatment diabetes mellitus. Thus, hypothesis was that Eryngium Caucasicum extract will decrease inflammation oxidative stress...