A5016939868- Natural Antidiabetic Agents Studies
- Arsenic contamination and mitigation
- Drug-Induced Hepatotoxicity and Protection
- Saffron Plant Research Studies
- Chemotherapy-induced organ toxicity mitigation
- Heavy Metal Exposure and Toxicity
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Sperm and Testicular Function
- Retinoids in leukemia and cellular processes
- Garlic and Onion Studies
- Pomegranate: compositions and health benefits
- Mesenchymal stem cell research
- Phytochemistry and Biological Activities
- Nerve injury and regeneration
- Antioxidant Activity and Oxidative Stress
- Neurogenesis and neuroplasticity mechanisms
- Renal and related cancers
- Chemotherapy-induced cardiotoxicity and mitigation
- Paraquat toxicity studies and treatments
- Curcumin's Biomedical Applications
- Diet, Metabolism, and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Sulfur Compounds in Biology
Ahvaz Jundishapur University of Medical Sciences
2016-2025
Cellular Research (United States)
2020
Faculty (United Kingdom)
2020
Islamic Azad University, Ahvaz Branch
2020
Islamic Azad University of Najafabad
2019
OBJECTIVE: This study investigated the quercetin (Que) effects on growth of MCF-7 human cancer breast cell line and its cellular death mechanism.BACKGROUND: Quercetin has been found to be very effi cacious against many different types cells.However, is not suffi ciently powered demonastrate anticancer mechanisms.METHODS: MCF-7cells were treated by 50 μM/ ml Que for 48 hours.MCF-7 cells also pretreated with 10 Μm ZVAD (apoptosis inhibitor) or 3 mM Nec-1 (necroptosis evaluation induced...
Background and objectives: Previous studies have shown anti-tumor activity of quercetin (QT). However, the low bioavailability QT has restricted its use. This study aimed to assess toxic effect encapsulated in solid lipid nanoparticles (QT-SLNs) on growth MCF-7 human breast cancer cells. Materials Methods: MCF-10A (non-tumorigenic cell line) lines treated with 25 µmol/mL or QT-SLNs for 48 h. Cell viability, colony formation, oxidative stress, apoptosis were evaluated determine effects...
Background . Liver ischemia‐reperfusion (IR) injury is one of the chief etiologies tissue damage during liver transplantation, hypovolemic shock, and so forth. This study aimed to evaluate hepatoprotective effect crocin on IR microRNAs (miR‐122 miR‐34a) expression. Materials Methods 32 rats were randomly divided into four groups: sham, IR, pretreatment (Cr), + (Cr IR) groups. In sham Cr groups, animals given normal saline (N/S) (200 mg/Kg) for 7 consecutive days, respectively, laparotomy...
Lung fibrosis is a chronic and intermittent pulmonary disease, caused by damage to the lung parenchyma due inflammation fibrosis. Epicatechin (Epi) as flavonoid has antioxidant anti-inflammatory properties. This study was conducted evaluate effect of Epi on oxidative stress, induced bleomycin (BLM) in mice. Accordingly, animals were randomly assigned into two groups 7 14 days role early late fibrotic phases BLM-induced injury, respectively. Each group divided six subgroups include control,...
Renal ischemia-reperfusion occurs in some clinical conditions such as kidney surgery that can leads to acute renal failure. The aim of this study was investigate the effect p-coumaric acid (CA) on ischemia reperfusion (I/R) injury.Thirty rats were randomly divided into five groups; control, CA (100mg/kg), I/R, propylene glycol (10%)+I/R and CA+I/R, (n=6 each). administered orally for 2 weeks. Then, subjected bilateral 45min followed by 24h. All killed function tests, tissue malondialdehyde...
Background and purpose: Acetaminophen (APAP) is a commonly used antipyretic pain reliever that its overdose causes acute liver toxicity. Umbelliferone (UMB) has many pharmacological effects. In this study, the hepatoprotective effect of UMB on hepatotoxicity induced by APAP was investigated. Experimental approach: Forty-nine male mice were separated into seven groups. The control received vehicle (i.p.), group (120 mg/kg, i.p.), treated with single dose (350 pretreated groups...
OBJECTIVE: The present study was designed to investigate the possible protection of pravastatin against hepatic oxidative stress and dysfunctions induced by doxorubicin in rats.BACKGROUND: Statins have benefi cial effects on infl ammation.METHODS: Male Sprague-Dawley rats were divided into four groups.Control group (received saline orally), Group 2 received (20 mg/kg, i.p. for 15 days), 3 single dose (15 i.p.), 4 treated with i.p.) daily from 5 days before 10 after injection i.p.).Hepatic...
Use of medicinal plants with high antioxidant properties could be effective to increase fertility and improvement disorders such as hormonal imbalance, impotency, oligospermia immotile sperm. Celery (Apium graveolens) is rich in agents. The leaf stems celery contain phenols, furanocoumarin luteolin. Apigenin one the main flavonoids leaf.This study aimed investigate effects hydroalcoholic extract on histological testis number sexual cells male rats.Thirty-two Wistar rats were divided into...