A5086347172- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Nanoparticles: synthesis and applications
- Traditional Chinese Medicine Analysis
- Paraquat toxicity studies and treatments
- Carcinogens and Genotoxicity Assessment
- MicroRNA in disease regulation
- Mycotoxins in Agriculture and Food
- Plant and fungal interactions
- Kruppel-like factors research
- Heme Oxygenase-1 and Carbon Monoxide
Ahvaz Jundishapur University of Medical Sciences
2018-2024
The key features of type 2 diabetes mellitus (T2DM) caused by high fat diet (HFD) in combination with arsenic (As) exposure (pronounced glucose intolerance despite a significant decrease insulin resistance) are different from those expected for T2DM. Autophagy has been considered as possible link between resistance and obesity. Therefore this study, we utilized autophagy gene expression profiling via real-time RT-PCR array analysis livers NMRI mice exposed to an environmentally relevant...
Previous studies have demonstrated the toxic impacts of zinc oxide nanoparticles (ZO-NPs) on male reproductive cells. The effect quercetin (QCT) ZO-NPs-induced mouse Sertoli cell (TM4 line) toxicity and its underlying mechanisms were investigated in this study. TM4 cells exposed to ZO-NPs or QCT different groups for 24 hr. pre-treated with 3MA (3-Methyladenine, an autophagy inhibitor) evaluate role significantly reduced viability percentage apoptosis Bax/Bcl-2 ratio group increased, while...
In stressful conditions, cells can have either temporary or irreversible cell cycle arrest. This ability helps regulate proliferation and differentiation prevent the spread of populations that be harmful. Similar to arrest, autophagy is induced inhibited as a function different conditions plays key role in protecting cell. our previous study, it was shown exposure arsenic (As) high-fat diet (HFD) resulted upregulation autophagy. this we used gene expression profiling co-regulators...