A5012100996- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Curcumin's Biomedical Applications
- MicroRNA in disease regulation
- Phytochemicals and Antioxidant Activities
- Organ Transplantation Techniques and Outcomes
- Phytochemical and Pharmacological Studies
- Cancer Mechanisms and Therapy
- Tannin, Tannase and Anticancer Activities
- Nitric Oxide and Endothelin Effects
- interferon and immune responses
- Entomological Studies and Ecology
- Medicinal plant effects and applications
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Treatment and Pharmacology
- Angiogenesis and VEGF in Cancer
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
- Cell death mechanisms and regulation
- Coconut Research and Applications
- RNA modifications and cancer
Ahvaz Jundishapur University of Medical Sciences
2019-2025
Shiraz University of Medical Sciences
2017
Hamedan University of Medical Sciences
2010
Background: Cancer is one of the major threatening factors human health worldwide. Unfortunately, chemotherapy, powerful arm cancer therapy, accompanied with many side effects, so alternative treatments greater specificities and fewer effects are highly required. Methods: Human cell lines including SW-742, HCT116, HepG2, Hep2, MKN45 LNcap were selected anti-cancer potential Cyrtopodion scabrum extract (CsE) on their growth was studied. Vero cells used to study cytotoxicity normal cells. Cell...
Breast cancer (BC) cells' ability to metastasize other tissues increases mortality. The Matrix metalloproteinases 2 and 9 (MMP-2 MMP-9) facilitate cell migration. 5-fluorouracil is a frequently applied chemotherapeutic agent in treatment with destructive side effects on normal tissues. Hence, researchers have focused finding way reduce the dose of drugs. Quercetin, natural polyphenolic compound, has inhibitory proliferation migration tumor cells. This study evaluated effect combination...
Curcumin Modulates NOX Gene Expression and ROS Production via P-Smad3C in TGF-β-Activated Hepatic Stellate Cells
Abstract Objective Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors breast cancer. The large family Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role TRIM3 and TRIM16 have shown suppressive activity different cancers. This study aimed to evaluate expression cancerous normal samples investigate association clinical pathological parameters. Results qRT-PCR was utilized...
Breast and colorectal cancers rank high in Iran as causes of mortality. Most the current treatments are expensive non-specific. The potential anticancer properties common home gecko, Cyrtopodion scabrum, were investigated this study. effects C. scabrum extract on proliferation, viability migration cancer (SW-742), breast (MCF-7) normal (MSC) cell lines using MTT vitro wound healing assay. <TEX>$IC_{50}$</TEX> values calculated for <TEX>$559{\pm}28.9{\mu}g/mL$</TEX> MCF-7...
The use of complementary and/or alternative medicine to increase the efficacy and decrease side effects current cancer treatment is highly required. In this in-vivo study, we aimed investigate anti-tumor activity probable a natural treatment, Cyrtopodion scabrum extract (CsE), in model tumor bearing mice.We established 28 female CT26-tumor balb/c-mice model. We divided them randomly into four groups (n=7): Negative control received distilled water (DW) three were administered with 5-FU two...
Currently, liver fibrosis is growing worldwide; unfortunately, there no definite cure for this disease. Hence, understanding the molecular pathways involved in development of can help to find a proper treatment. In study, we aimed evaluate effects isorhamnetin as an antifibrotic agent on platelet-derived growth factor (PDGF)-BB-activated hepatic stellate cells (HSC)-T6 concentration-dependent manner. We have also attempted assess signaling that may affect fibrosis.
Activated cells which are called star-shaped cells, some of the key factors in development liver fibrosis. Activation NADPH oxidase (NOX) is associated with increased HSCs activity and progression hepatic In this study, effects human exosomes derived from WJ-MSCs on NOX1, NOX2, NOX4 gene expression TGF-β-induced fibrosis were investigated.LX2 cell line was treated 2 ng/ml TGF-β for 24 hr, order to induce after starvation. next step, several concentrations (10, 20, 30, 40, 50 μg/ml). Finally,...
Background: The endothelial nitric oxide synthase (eNOS) gene encodes the eNOS enzyme in humans; it synthesizes (NO), which prevents or promotes colorectal cancer (CRC) progression. Polymorphisms of are correlated with probability cancer, but findings not consistent. Objectives: present study aimed at investigating correlation rs1799983 polymorphism CRC compared to control group. Methods: (G894T) was assessed 100 healthy subjects and patients CRC. Polymerase chain reaction (PCR) polymerase...
<title>Abstract</title> <bold>Background: </bold>Quercetin (QC) is a natural flavonoid abundant in fruits and vegetables. The anticancer anti-inflammatory effects of quercetin have been reported previously, but the clinical application has limited because its low bioavailability. Triple-negative breast cancer type that responds poorly to chemotherapy. This study aims determine anti-cancer impact quercetin-solid lipid nanoparticles (QC-SLN) on triple-negative cell line MDA-MB231....
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. The current remedies for cancer, including chemotherapy and radiation therapy, might damage patients’ organs, sometimes causing death. Etoposide (ETO), as a widely used chemo-drug, possesses same problems. For years, combinational therapy has been considered potential adjustor treatments, alleviating their side effects. Quercetin (Que), phytochemical drug, due to its against cancer. Objectives: This...
Free cholesterol in the diet can cause liver fibrosis by accumulating Hepatic stellate cells (HSCs). The rate of mortality this disease is high worldwide and there no definite remedy for it, but might be treated anti-fibrotic therapies. MSCs-derived exosomes are known as new mechanism cell-to-cell communication, showing that used a treatment. In study, we investigated ability WJ-MSCs to reduce cholesterol-induced LX2 cell line.MSCs were isolated from Wharton's jelly umbilical cord extracted....
Elevated brain cholesterol increases the risk of Alzheimer's disease. Production 24-hydroxycholesterol (24s-OHC) by neurons prevents accumulation in brain. In this study, we investigated effect 24s-OHC on HMG-COA reductase and ABCA1 which are involved homeostasis with or without β-amyloid astrocytes.Astrocytes were treated Aβ. Western blot real-time polymerase chain reaction done to detect protein gene expression β-hydroxy-3-methyl-glutaryl-coenzyme A (HMGCR) ABCA1, respectively. Cholesterol...