Epithelial Mesenchymal Transition (EMT) is a dedifferentiation process implicated in many physio-pathological conditions including tumor transformation. EMT regulated by several extracellular mediators and under certain it can be reversible. Autophagy conserved catabolic which intracellular components such as protein/DNA aggregates abnormal organelles are degraded specific lysosomes. In cancer, autophagy plays controversial role, acting different both suppressor tumor-promoting mechanism....

Breast cancer is a widely prevalent and life-threatening malignancy that affects women worldwide. The identification of novel molecular markers associated with tumor progression highly important for enhancing early detection, tailoring treatment approaches, monitoring therapeutic outcomes. In this study, we investigated the expression patterns four long noncoding RNAs (lncRNAs): USP30 antisense RNA1 (USP30-AS1), ELFN1 (ELFN1-AS1), GAS8 (GAS8-AS1), small nucleolar RNA host gene 11 (SNHG11)....

The antioxidant system can be critical in reducing exacerbated inflammation COVID-19. This study compared the and inflammatory responses between COVID-19 outpatients seemingly healthy individuals. descriptive-analytical cross-sectional was conducted on 53 individuals as controls. serum concentrations of amyloid A (SAA), total capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx) were measured patients controls using independent sample t-test before after controlling for...

Abstract Mesenchymal stem cells (MSCs), recognized as a promising candidate for treating degenerative diseases, have garnered significant attention from scientists in recent decades. However, notable concern associated with MSCs is their low stability and viability. In previous study, we found that dimethyl fumarate (DMF) at 10 μM concentration can enhance the proliferation of increase stability. this research, performed protein extraction digestion on both DMF-treated MSCs, subsequently...

Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations 25-hydroxyvitamin (25(OH)D) in COVID-19 outpatients with those potentially non-infected participants. The association clinical symptoms vitamin status was also examined. A checklist laboratory examination were applied to collect data a cross-sectional conducted on 53 infected Serum concentration 25(OH)D not significantly lower patients moderate illness (19 ± 12 ng/mL) than...

The accumulation of amyloid plaques and disturbance cholesterol homeostasis are implicated in the pathophysiology Alzheimer's disease. Apolipoprotein E (ApoE) 24-hydroxylase (CYP46A1) key proteins involved efflux metabolism excess cholesterol, small non-coding RNAs (miRNAs), can help to regulate expression genes encoding these proteins. aim present study was investigate alterations APOE CYP46A1 genes, as well their respective regulatory miRNAs, astrocytes treated with beta (Aβ). In this...

Based on the available evidence, cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed examine levels CIRBP and HIF1α mRNA within breast tumor tissues explore relationship between their gene expression Microvascular density (MVD). The results revealed significant upregulation (5.07-fold) (4.5-fold) BC samples compared surrounding normal (p < 0.001). was also associated with various...

Airway remodelling is characterized by the thickening and reorganization of airways seen in mustard lung patients. Mustard general description for chronic obstructive pulmonary disease induced sulfur mustard(SM). Pulmonary was diagnosed as most important disorder individuals that had been exposed to mustard. Sulfur a chemical warfare agent developed during Wars. Iraqi forces frequently used it against Iranian Iran -Iraq 1980-1988. Peribronchial fibrosis result from airway remodeling include...

We aimed to evaluate whether traditional and non-traditional adiposity indicators are associated with cardiometabolic risk factors among adult patients type 2 diabetes mellitus (DM).In this cross-sectional study 240 inpatients DM, we determined anthropometric including body mass index, waist circumference, hip circumference (HC), waist-to-hip ratio (WHR), waist-to-height ratio, lipid accumulation product (LAP), visceral index (VAI), deep abdominal adipose tissue (DAAT), Després indices....

Abstract Objective Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors breast cancer. The large family Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role TRIM3 and TRIM16 have shown suppressive activity different cancers. This study aimed to evaluate expression cancerous normal samples investigate association clinical pathological parameters. Results qRT-PCR was utilized...

Since the outbreak of COVID-19 in China, it has rapidly spread across many other countries. We evaluated antioxidant defense systems and inflammatory status related to SARS-CoV2 infection a population from southwestern Iran. Comorbidities clinical symptoms 104 subjects (comprising negative positive-PCR outpatients) were assessed. Serum concentrations glutathione reductase (GR) interleukin-10 (IL-10) measured using ELISA. In group, follow-ups on carried out for 28 days at 7-day intervals....

Sepsis-associated encephalopathy (SAE) is a common brain dysfunction following sepsis. Due to the beneficial effects of mesenchymal stem cells (MSCs) therapy on anxiety, an extreme and early manifestation SAE, we hypothesized that MSCs-derived conditioned medium (CM) may be able attenuate anxiety in cecal ligation puncture (CLP)-induced sepsis.Rats were assigned into 4 groups: sham, CLP, MSC, CM. All animals, except sham group, underwent CLP procedure induce Two hours after sepsis induction,...

Evidence show that the recommended dose of zinc may not be sufficient for controlling pathological conditions such as type 2 diabetes mellitus (T2DM).This study aimed to evaluate effects supplementation on oxidative status in overweight T2DM. In addition, routine glycaemic parameters were determined and compared zinc-treated placebo groups.In this randomised, double-blind, placebo-controlled trial, 70 patients with T2DM selected. They divided into two groups 50 mg gluconate or (zinc group,...

Breast cancer is a leading cause of incidence and mortality in women globally. Identifying new molecular markers can aid diagnosis, targeted therapy, treatment monitoring. This study aimed to measure the expression X-box binding protein 1 (XBP1) gene, an index unfolded response (UPR), long noncoding RNAs (lncRNAs), including Nuclear Enriched Abundant Transcript (NEAT1), Cancer Susceptibility Candidate 2 (CASC2), Long Intergenic Nonprotein Coding RNA 299 (LINC00299), as possible regulators...