A5092260718- MicroRNA in disease regulation
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Retinoids in leukemia and cellular processes
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Phagocytosis and Immune Regulation
- Curcumin's Biomedical Applications
- Organ Transplantation Techniques and Outcomes
- Adipose Tissue and Metabolism
- Synthesis and biological activity
Ahvaz Jundishapur University of Medical Sciences
2023-2025
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are 2 common diseases that currently lack effective treatment options.This study aimed to investigate the effect of lipopolysaccharide (LPS)-stimulated adipose-derived stem cells (ADSCs) on NAFLD in an animal model.Male Wistar rats were fed a high-fat diet (HFD) induce for 7 weeks. The then categorized into 3 groups: Mesenchymal cell (MSC), MSC + LPS, fenofibrate (FENO) groups. Liver body weight measured,...
Abstract: Ovarian cancer (OC) is a gynecologic disease characterized by the uncontrolled growth and proliferation of abnormal cells in ovaries, fallopian tubes, or peritoneum. Emerging evidence has shown pivotal role non-coding RNAs (ncRNAs), such as miRNAs, driving pathogenesis OC. miRNAs are recognized small ncRNAs that play critical roles regulating gene expression normal development states, including Among miR-34a was found to be downregulated Elevated levels this miRNA associated with...
The accumulation of amyloid plaques and disturbance cholesterol homeostasis are implicated in the pathophysiology Alzheimer's disease. Apolipoprotein E (ApoE) 24-hydroxylase (CYP46A1) key proteins involved efflux metabolism excess cholesterol, small non-coding RNAs (miRNAs), can help to regulate expression genes encoding these proteins. aim present study was investigate alterations APOE CYP46A1 genes, as well their respective regulatory miRNAs, astrocytes treated with beta (Aβ). In this...
Non-alcoholic fatty liver disease (NAFLD) is the most common liver-related metabolic disorder in world, with a global prevalence of 25%. Compounds anti-inflammatory, lipid-lowering, and insulin-sensitizing properties can be used for prevention or treatment NAFLD. Therefore, this study was conducted to investigate effect saroglitazar (a dual PPARα/γ agonist) diosmin flavonoid) on non-alcoholic induced by high-fat diet (HFD) Wistar rats.
Background: Hepatic fibrosis is characterized by the increased proliferation and activation of hepatic stellate cells. Transforming growth factor-beta (TGF-β) stimulates these cells, leading to development liver fibrosis. MicroRNA-146a microRNA-29b have been identified as significant regulatory factors in fibrogenesis. Objectives: In this study, we investigated ability exosomes alleviate enhancing antifibrotic effects miR-146a miR-29b. Methods: The LX-2 cells were exposed TGF-β for 24 hours....
Combining natural compounds with chemotherapeutic agents has emerged as a promising approach for cancer treatment. Curcumin (Cur), polyphenol, is known its anti-cancer properties, including the ability to induce apoptosis and arrest cell cycle progression. This study aimed evaluate effects of Cur etoposide (ETO), both individually in combination, on induction breast (BC) lines. The impact ETO proliferation was assessed using MTT viability assays. Apoptosis by these drugs evaluated through...