A5057753900- Nanoparticle-Based Drug Delivery
- Curcumin's Biomedical Applications
- Advancements in Transdermal Drug Delivery
- Dental Trauma and Treatments
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Electrospun Nanofibers in Biomedical Applications
- Biochemical effects in animals
- Antiplatelet Therapy and Cardiovascular Diseases
- Bioactive Compounds and Antitumor Agents
- Surfactants and Colloidal Systems
- Bone Metabolism and Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Berberine and alkaloids research
- Synthesis and bioactivity of alkaloids
- Multiple Sclerosis Research Studies
- Lipid Membrane Structure and Behavior
- Flavonoids in Medical Research
- Plant-based Medicinal Research
- Signaling Pathways in Disease
- Saffron Plant Research Studies
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Memory and Neural Mechanisms
George Mason University
2025
Zanjan University of Medical Sciences
2015-2023
Tehran University of Medical Sciences
2011-2017
Universitas Sahid Jakarta
2014
Shiraz University of Medical Sciences
2006
The blood–brain barrier (BBB) acts as a physical/biochemical that protects brain parenchyma from potential hazards exerted by different xenobiotics found in the systemic circulation. This is created "a lipophilic gate" well series of highly organized influx/efflux mechanisms. BBB bottleneck adversely affects efficacy chemotherapeutic agents treating CNS malignancies such glioblastoma, an aggressive type cancer affecting brain. In present study, mesoporous silica nanoparticles (MSNs) were...
Cytotoxic effects of some the members papaveraceae family have been reported in Iranian folk medicine. Recent reports has indicated that alkaloids fraction opium may be responsible for its cytotoxic effect; however, mechanism this effect is not fully understood. This study designed to investigate selective cytotoxic, genotoxic and also apoptosis induction noscapine, papaverine narceine, three non-addictable alkaloids, on HT29, T47D HT1080 cancer cell lines. Mouse NIH3T3 line was chosen...
Erlotinib is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor, but development erlotinib resistance during chemotherapy can lead to treatment failure. To shed light on erlotinib‐resistant pathway, this study investigated effect combination therapy using curcumin‐ erlotinib‐loaded nanoparticles expression α v β 3 integrin pyruvate dehydrogenase kinase 4 (PDK4) in an SW480 colon cancer cell line. An line was produced by long‐term exposure erlotinib....
In the hippocampal formation, cholinergic modulation from medial septum/diagonal band of Broca (MSDB) is known to correlate with speed an animal's movements at sub-second timescales and also supports spatial memory formation. Yet, extent which dynamics, if all, align transient behavioral cognitive states supporting encoding novel information remains unknown. this study, we used fiber photometry record temporal dynamics in population activity septo-hippocampal neurons resolution during a...
Context: Cancer is a disease characterized by abnormal growth of cells. One the most common types liver cancers called hepatocellular carcinoma (HCC) which highly metastatic. As cannabinoids have shown anticancer effect against different cell lines in number reports, biological investigation two cannabinoids, CB65 (CB2 receptor agonist) and ACEA (CB1 was carried out this study.Objective: In an attempt to find natural products as new solution cancer, study designed investigate potential...
: Chemotherapy fails to eradicate cancer cells, mainly due the lack of selective drug accumulation into tumor site, which can affect healthy as well. In this research, we studied magnetite nanostructured lipid carriers (NLCs) for targeted delivery curcumin breast cells. Superparamagnetic iron oxide nanoparticles (SPIONs) were prepared using coprecipitation method by mixing FeCl2 and FeCl3 in a suitable ratio alkaline media. The resultant ferrofluid was very stable possessed high magnetic...
Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor activated T cell (NFAT) pathway unclear. AhR NFAT signaling pathways have common roles pathological functions immunotoxicity lung cancer. In this study, effect activation on expression cross talk NFATc1...
Background:The association of prior cerebrovascular disease (CeVD) with adverse clinical outcomes in PCI patients is unclear Purpose: To determine whether history CeVD influences physicians' treatment choices and after presenting acute coronary syndromes (ACS).Methods: PROMETHEUS a multicenter observational registry comprising 19914 ACS treated receiving either clopidogrel or prasugrel at the physician discretion.Patients were grouped according to presence CeVD, defined as stroke, transient...