A5009342270- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Curcumin's Biomedical Applications
- Dendrimers and Hyperbranched Polymers
- Endoplasmic Reticulum Stress and Disease
- Metal-Organic Frameworks: Synthesis and Applications
- Lipoproteins and Cardiovascular Health
- Computational Drug Discovery Methods
- Nanomaterials for catalytic reactions
- Corneal Surgery and Treatments
- Iron oxide chemistry and applications
- Ocular Surface and Contact Lens
- Herpesvirus Infections and Treatments
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Photodynamic Therapy Research Studies
- Autophagy in Disease and Therapy
- Chemical Synthesis and Characterization
- Nonlinear Optical Materials Studies
- Atherosclerosis and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Magnetic Properties and Synthesis of Ferrites
- Advanced Breast Cancer Therapies
- Fullerene Chemistry and Applications
Université de Montréal
2024
Hôpital Maisonneuve-Rosemont
2024
University of Guilan
2022-2024
Zanjan University of Medical Sciences
2017-2022
Biotechnology Research Center
2022
University of Tehran
2019
Cornell University
2018
Case Western Reserve University
2018
Hospital for Sick Children
2014-2017
SickKids Foundation
2017
Metal organic frameworks (MOFs) UiO‐66 (UiO stands for University of Oslo) and NH 2 ‐UiO‐66 were prepared characterized as sorbent (antidotal agents) curcumin (CUR) adsorption. The structure products by X‐ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Attenuated Total Reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), N adsorption–desorption measurements. FESEM showed displayed symmetrical crystals with...
Abstract Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness. We developed an injectable Cornea-in-a-Syringe (CIS) sealant-filler to treat damaged corneas. CIS comprises linear carboxylated polymers of inflammation-suppressing 2-methacryloyloxyethyl phosphorylcholine, regeneration-promoting collagen-like peptide, adhesive collagen-citrate glue. also incorporated GF19, a modified...
Abstract In this project, a core‐shell polymersome based on miktoarm star‐copolymer:methoxy poly‐ethylene glycol‐lysine‐(poly‐caprolactone) 2 was synthesized by new method as controlled targeted drug delivery systems for codelivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties these nanocarriers (NCs), such surface morphology, structure, charge, stability, biocompatibility, were evaluated proton nuclear magnetic resonance, dynamic scanning colorimetry,...
Miktoarm star copolymers are relatively considered to be a new and unique class of macromolecules, topical area due the properties by varying their polymer arms. This macromolecules with AmBn architecture, have m arms A n B connected at one central junction point. Over past decade, miktoarms been used in biomedical applications such as drug delivery, gene tissue engineering, diagnosis, antibacterial/antifouling biomaterials. The intensified interest is attributed topological structures...
In The present project, a variety of MnFe2O4 (Mn) and Cr2Fe6O12 (Cr)-based nanocarriers (NCs) were synthesized as photosensitizer NCs for delivery chemotherapeutic curcumin (CUR) provide new structure Photodynamic Therapy (PDT). For determining efficiency release study, MTT assay, lethal dose test hemolysis assay carried out. study showed the CUR from was pH-dependent, but, every had its own behavior releasing drug. data acquired Mn can reach to over 90% at acidic media instead 41% neutral...
In this study, methoxy poly (ethylene glycol)-poly (ε-caprolactone) (mPEG-PCL) di-block copolymers were synthesized. The purpose of work is to investigate the in vivo anti-inflammatory effects simvastatin-loaded micelles.The structure synthesized was characterized by using HNMR, FTIR, and GPC techniques. Simvastatin encapsulated micelles through a single-step nano-precipitation method, leading formation mPEG-PCL (simvastatin-mPEG-PCL) micelles. simvastatin/mPEG-PCL versus indomethacin...
AUP1 (ancient ubiquitous protein 1) is an endoplasmic reticulum-associated that also localizes to the surface of lipid droplets (LDs), with dual role in quality control and LD regulation. Here, we investigated hepatic mobilization demonstrate critical roles intracellular biogenesis apoB100 (apolipoprotein B-100), mobilization, very-low-density lipoprotein (VLDL) assembly secretion. APPROACH AND RESULTS: siRNA (short/small interfering RNA) knockdown significantly increased secretion...
In this project, a biocompatible block copolymer including poly ethylene glycol and caprolactone was synthesized using ring-opening reaction. Then, the conjugated to folic acid lysine as linker. Also, curcumin (CUR) used therapeutic anticancer agent. Nanoprecipitation method prepare CUR-loaded polymeric micelles. Different methods Fourier-transform infrared spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS) were characterize prepared nanocarriers (NCs). MTT...
In this study, we synthesized methoxy poly(ethylene glycol)-poly(ε-caprolactone) diblock copolymers as water soluble nanocarriers to investigate the in vivo anti-inflammatory characteristic of rosuvastatin-loaded nanocarriers. For determining structure prepared nanocarriers, used proton nuclear magnetic resonance, gel permeation chromatography, Fourier-transform infrared spectroscopy, atomic force microscopy, and dynamic scanning calorimetry method. Nano-precipitation method was for loading...
The graphene-based additives containing polyethyleneimine (PEI) or hydroxyapatite (HAP) were synthesized and their effects on the flame retardancy, thermal, mechanical properties of polyvinyl alcohol (PVA) matrix evaluated. Thermogravimetric analysis studies (TGA) Scanning electron microscope (SEM) images indicated that PEI HAP have a strong influence fire behavior composites which might be explained by forming uniform compact char during combustion. presence nitrogen in phosphorus are...
Abstract Corneal HSV-1 infections are a leading cause of infectious blindness globally by triggering tissue damage due to the intense inflammation. treated mainly with antiviral drugs that clear but inefficient as prophylactics. The body produces innate cationic host defence peptides (cHDP), such cathelicidin LL37. Various epithelia, including corneal epithelium, express cHDPs can disintegration pathogen membranes, stimulate chemokine production, and attract immune cells. Here, we selected...