A5076113293- Heat shock proteins research
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Enzyme Production and Characterization
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Protein purification and stability
- Advanced Biosensing Techniques and Applications
- Insect and Pesticide Research
- MicroRNA in disease regulation
- Phytochemicals and Antioxidant Activities
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Essential Oils and Antimicrobial Activity
- Protein Hydrolysis and Bioactive Peptides
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- Catalysis for Biomass Conversion
- Insect Utilization and Effects
- SARS-CoV-2 and COVID-19 Research
University of Guilan
2014-2024
Islamic Azad University Rasht Branch
2017
Protecting a surface-immobilised enzyme with an enzyme-thin organosilica layer produced using protein chaperone building block allows drastic improvement in the enzyme's thermal stability.
Angiogenesis is a hallmark of various pathological conditions and controlled by variety angiogenic factors. Blockade vascular endothelial growth factor (VEGF) as the most pivotal stimulator angiogenesis offers promising therapeutic approach for some diseases, typically cancer. In present study, heterodimeric antagonistic VEGF was precisely designed based on structural information recently-crystallized VEGF/VEGF receptor-2 (VEGFR-2/fetal liver kinase 1/kinase domain region) complex. Directed...
Background: MicroRNAs (miRNAs) participate in gene regulation and the control of cancer-related mechanisms such as apoptosis, invasion differentiation. Single nucleotide polymorphisms (SNP) miRNA encoding genes may influence development cancer. We hypothesized a link between miR-559 SNP rs58450758 breast cancer.Materials & methods: Bioinformatics analyses were performed to predict target effect on stem-loop structure. A total 129 cancer cases 153 controls genotyped using PCR-RFLP.Results:...
Encysted embryos of Artemia are among the most stress-resistant eukaryotes partly due to massive amount a cysteine-rich protein termed artemin. High number cysteine residues in artemin and their intramolecular spatial positions motivated us investigate role chaperone-like activity According result Ellman's assay, there nine free thiols (seven buried two exposed) one disulfide bond per monomer Subsequent theoretical analysis predicted 3D structure confirmed data obtained by spectroscopic...
Abstract Despite research efforts to unravel the role of naturally occurring deep eutectic solvents (NADESs) in living cells, there are still many questions left unanswered. The proposed hypothesis about NADESs cryopreservation and resistance cells motivated us investigate whether DESs might possess chaperoning activity. Accordingly, here, chaperone‐like activity a well‐known DES, urea‐choline chloride DES (UC), on model protein, lysozyme, has been evaluated. results showed that UC was not...
Bioactive peptides from marine protein sources hold tremendous promise as potent antioxidant agents with plausible anticancer activity. Herein, the activities of crab hydrolysate and its ultrafiltration fractions at different molecular weights (>30 kDa,10–30 kDa,3–10 kD and<3 kDa) using various methods (DPPH, ABTS FRAP assay) were investigated carefully. The results showed that although all peptide some activity, low weight (3–10 kDa <3 generated highest a high content hydrophobic amino...
Introduction: MicroRNAs (miRNAs) are small ribonucleic acids that modulate the expression of downstream target genes. There is considerable evidence their involvement in many malignancies, such as oesophageal and gastric. We hypothesised altered expressions pri-miR-124-1 rs531564 STAT3 rs1053023 polymorphisms gastric cancer.Materials methods: Genomic DNA was extracted from peripheral blood 250 patients with cancer 310 healthy individuals. The RFLP method applied for determination pri-miR-124...
A proteochemometric study of a set phosphodiesterase 4B and 4D inhibitors sheds light on the origin their inhibition selectivities.