A5083856551- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Redox biology and oxidative stress
- Curcumin's Biomedical Applications
- Sulfur Compounds in Biology
- Glutathione Transferases and Polymorphisms
- Receptor Mechanisms and Signaling
- Nanoplatforms for cancer theranostics
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine Tumor Research Advances
- Regulation of Appetite and Obesity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Selenium in Biological Systems
- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Oral microbiology and periodontitis research
- T-cell and Retrovirus Studies
- Cancer Immunotherapy and Biomarkers
- Tuberculosis Research and Epidemiology
Mashhad University of Medical Sciences
2016-2025
Imam Reza Hospital
2014-2018
Nobel Foundation
2006-2008
Karolinska Institutet
2006-2008
Hohenstein Institute
2008
Mercury toxicity mediated by different forms of mercury is a major health problem; however, the molecular mechanisms underlying remain elusive. We analyzed effects mercuric chloride (HgCl(2)) and monomethylmercury (MeHg) on proteins mammalian thioredoxin system, reductase (TrxR) (Trx), glutaredoxin glutathione (GR) (Grx). HgCl(2) MeHg inhibited recombinant rat TrxR with IC(50) values 7.2 19.7 nm, respectively. Fully reduced human Trx1 bound lost all five free thiols activity after incubation...
This study investigates the efficacy and toxicity profiles of pegylated liposomal doxorubicin (Doxil) compared to conventional doxorubicin. Additionally, it evaluates potential combination therapy involving Doxil with aprepitant, an FDA-approved agent for management chemotherapy-induced nausea vomiting. Using a mouse model induced 4T1 breast cancer cells, tumor size, weight were assessed following treatment either single doses or therapies. The also examined oxidative antioxidant stress...
The mammalian cytosolic/nuclear thioredoxin system, comprising (Trx), selenoenzyme reductase (TrxR), and NADPH, is the major protein-disulfide of cell has numerous functions. active site reduced Trx comprises Cys32-Gly-Pro-Cys35 thiols that catalyze target disulfide reduction, generating a disulfide. Human Trx1 also three structural Cys residues in positions 62, 69, 73 upon diamide oxidation induce second Cys62–Cys69 as well dimers multimers. We have discovered after incubation with H2O2...
Motexafin gadolinium (MGd) is a chemotherapeutic drug that selectively targets tumor cells and mediates redox reactions generating reactive oxygen species. Thioredoxin (Trx), NADPH, thioredoxin reductase (TrxR) of the cytosol/nucleus or mitochondria are major thiol-dependent reductases with many functions in cell growth, defense against oxidative stress, apoptosis. Mammalian TrxRs selenocysteine-containing flavoenzymes; MGd was an NADPH-oxidizing substrate for human rat TrxR1 Km value 8.65...
Turmeric is a widely used spice derived from the rhizomes of Curcuma longa. Having been as dietary spice, it has drawn scientists' attention to possible medicinal benefits its active compounds called curcuminoids which consist curcumin, demethoxycurcumin and bisdemethoxycurcmin. Considering wide range pharmacological properties that curcumin offers, numerous studies have investigated potency therapeutic agent in various diseases such autoimmune, cardiovascular, neoplastic, pulmonary,...
Glutathione (GSH) is the major intracellular thiol present in 1-10-mm concentrations human cells. However, redox potential of 2GSH/GSSG (glutathione disulfide) couple cells varies association with proliferation, differentiation, or apoptosis from -260 mV to -200 -170 mV. Hydrogen peroxide transiently produced as second messenger receptor-mediated growth factor signaling. To understand oxidation mechanisms by GSSG nitric oxide-related nitrosylation we studied effects on glutaredoxins (Grx),...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic disease, while no drugs have been approved for its treatment. The pieces of evidence indicate that propolis as a novel anti‐inflammatory agent might be promising candidate to treat NAFLD. We aimed evaluate efficacy on hepatic steatosis and fibrosis in patients with This randomized clinical trial was conducted 54 Patients were randomly assigned receive tablets at dose 250 mg twice daily 4 months or placebo. improvement...
Although there is no doubt regarding the involvement of oxidative stress in development glioblastoma, many questions remained unanswered about signaling cascades that regulate redox status. Given importance substance P (SP)/neurokinin 1 receptor (NK1R) system different cancers, it was particular interest to evaluate whether stimulation this cascade glioblastoma-derived U87 cells associated with induction stress. Our results showed SP-mediated activation NK1R not only increased intracellular...