A5100704065- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Silk-based biomaterials and applications
- Hernia repair and management
- 3D Printing in Biomedical Research
- VLSI and FPGA Design Techniques
- Immunotherapy and Immune Responses
- VLSI and Analog Circuit Testing
- Cardiac Ischemia and Reperfusion
- Dental Implant Techniques and Outcomes
- Advancements in Photolithography Techniques
- Advanced biosensing and bioanalysis techniques
- Oral and gingival health research
- Magnesium Alloys: Properties and Applications
- Corrosion Behavior and Inhibition
- 3D IC and TSV technologies
- Advanced Nanomaterials in Catalysis
- Hydrogels: synthesis, properties, applications
University Medical Center Groningen
2022-2025
University of Groningen
2019-2025
University of Helsinki
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Beijing University of Chemical Technology
2023
Changhai Hospital
2023
Second Military Medical University
2023
Shanghai Jiao Tong University
2018-2022
Ruijin Hospital
2018-2022
Soochow University
2016-2022
Abstract We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The was prepared by cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) silver nitrate (AgNO3). Due to the dynamic nature Ag-S coordination bond bacteria-killing activity Ag+, resultant featured self-healing, injectable properties. In this study, we synchronously loaded drug, desferrioxamine (DFO), in during cross-linking....
Abstract The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole process, example, multifunctional injectable, degradation, antibacterial, antihypoxic, and wound healing–promoting properties that match dynamic process skin flap regeneration, is currently a research challenge. Here, coordinative polyethylene glycol (PEG) hydrogel mangiferin liposomes (MF‐Lip@PEG) developed clinical applications through Ag–S coordination four‐arm‐PEG‐SH Ag + ....
As a result of the deficient tumor-specific antigens, potential off-target effect, and influence protein corona, metal-organic framework nanoparticles have inadequate accumulation in tumor tissues, limiting their therapeutic effects. In this work, pH-responsive linker (L) is prepared by covalently modifying oleylamine (OA) with 3-(bromomethyl)-4-methyl-2,5-furandione (MMfu) poly(ethylene glycol) (PEG). Then, L embedded into solid lipid nanoshell to coat apilimod (Ap)-loaded zeolitic...
Periosteum plays the pivotal role in neomineralization, vascularization and protection during bone tissue regeneration. However, many artificial periosteum focused only on lacked of osteogenesis angiogenesis functional capacity. In this study, we developed a novelty inorganic strengthened gelatin hydrogel membrane via organic co-cross-linked double network as for enhancing durable reconstruction. Mesoporous bioactive glass nanoparticles (MBGNs) chemically modified with photo-cross-linkable...
Current homogeneous bioscaffolds could hardly recapture the regenerative microenvironment of extracellular matrix. Inspired by peculiar nature dura matter, we developed an matrix-mimicking scaffold with biomimetic heterogeneous features so as to fit multiple needs in mater repairing. The inner surface endowed anisotropic topology and optimized chemical cues orchestrate elongation bipolarization fibroblasts preserve quiescent phenotype indicated down-regulated α-smooth muscle actin...
Stent implantation is a well-accepted alternative to treat benign luminal disease (BLD). Current stents are often fabricated from plastic, mental and biodegradable materials, the latter two have wider clinical application. Self-expanding plastic possessed many disadvantages such as stent migration, tissue hyperplasia, in-stent restenosis difficult remove, which catalyzes development of (BDS). In fact, BDS not required be removed upon implementation leaves no residues in after complete...
There is a high local recurrence (LR) rate in breast-conserving therapy (BCT) and enhancement of the treatment promising as way to improve this. Thus we propose drug delivery system using doxorubicin (DOX)-loaded mesoporous silica nanoparticle composite nanofibers which can release anti-tumor drugs two phases-burst early stage sustained at later stage-to reduce LR BCT. In present study, designed novel nanofibrous scaffold realize efficient by loading both DOX DOX-loaded nanoparticles into an...
AIE nanoparticles show mitochondrial targeting, harvest FR/NIR emission and exert severe ROS cytotoxicity under ultralow-power-intensity (10 mW cm<sup>−2</sup>) light irradiation.
Fixation and permeabilization of cells tissues are essential processes in biological techniques like immunofluorescence immunohistochemistry for cell biology studies. In typical procedures, the samples treated by paraformaldehyde Triton X-100 to achieve cellular fixation permeabilization, respectively, prior incubation with specific antibodies. While it is well known that integrity membrane has been broken during these processes, quantitative studies on loss mass density enhancement...
Surgery is the final choice for most patients with intervertebral disc degeneration (IDD). Operation-caused trauma will cause inflammation in disc. Serious tissue defects and induce degeneration, IDD recurrence occurrence of other diseases. Therefore, we proposed a scheme to treat after discectomy by inhibiting an aspirin (ASP)-loaded hydrogel restore mechanical stability spine relieve local inflammation. ASP-liposomes (ASP-Lips) were incorporated into photocrosslinkable gelatin-methacryloyl...
An alternative strategy of choosing photothermal and weak-immunostimulatory porous silicon@Au nanocomposites as particulate cores to prepare a biomimetic nanovaccine is reported improve its biosafety immunotherapeutic efficacy for solid tumors. A quantitative analysis method used calculate the loading amount cancer cell membranes onto nanocomposites. Assisted with foreign-body responses, these exogenous nanoparticulate weak immunostimulatory effect can still efficiently deliver into...
Abstract The small interfering RNA (siRNA)‐based therapeutics have raised great attention since the first interference (RNAi)‐derived drug, patisiran, was approved by US Food and Drug Administration, which represented a landmark in field of gene therapy. Given properties disease‐associated expression, RNAi machinery is regarded as an essential factor for preparing precise medicine. However, over past few years, siRNA drugs are undergoing period clinical translation, major hurdle limited...
A two-dimensional (2D) cell culture-based model is widely applied to study tumorigenic mechanisms and drug screening. However, it cannot authentically simulate the three-dimensional (3D) microenvironment of solid tumors provide reliable predictable data in response vivo , thus leading research illusions failure In this study, honeycomb-like gelatin methacryloyl (GelMA) hydrogel microspheres are developed by synchronous photocrosslinking microfluidic technique construct a 3D osteosarcoma. The...
In the last years there has been a booming in development of biological pharmaceuticals, and various nanoparticle delivery systems have developed to overcome barriers maximize therapeutic potentials.Especially, when these drug-loaded arrive at target cells, they must be successfully internalized into followed by endosome escape, release payload cytoplasm.This is crucial so that payloads are not degraded (around pH 6.8-6.0) or lysosome 4.5).Considering acid environment endosome, several...
Osteosarcoma is among the most common malignant bone tumors in human skeletal system. The conventional treatment of osteosarcoma mainly consists combining neoadjuvant chemotherapy with surgical approach. However, it crucial to design an artificial implant that possesses excellent biomechanical properties and capable sustaining local release chemotherapeutics. In this study, we envision highly efficient combination gemcitabine (GEM) hydrochloride loaded liposomes gelatin methacryloyl (GelMA)...