A5011024192- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Asphalt Pavement Performance Evaluation
- Electrospun Nanofibers in Biomedical Applications
- Spine and Intervertebral Disc Pathology
- Grouting, Rheology, and Soil Mechanics
- Infrastructure Maintenance and Monitoring
- Wound Healing and Treatments
- Geotechnical Engineering and Soil Mechanics
- Geotechnical Engineering and Underground Structures
- biodegradable polymer synthesis and properties
- Advanced Nanomaterials in Catalysis
- Total Knee Arthroplasty Outcomes
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Cancer Research and Treatments
- Hydrogels: synthesis, properties, applications
- Transport Systems and Technology
- Anesthesia and Neurotoxicity Research
- Geomechanics and Mining Engineering
- Congenital heart defects research
- Hydrogen's biological and therapeutic effects
- Soil, Finite Element Methods
Ruijin Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Jiaxing University
2024
Tongji University
2017-2022
Chinese Academy of Sciences
2018-2021
Shenzhen Institutes of Advanced Technology
2021
Shanghai Advanced Research Institute
2018
Wuhan University of Technology
2009-2014
As a result of the deficient tumor-specific antigens, potential off-target effect, and influence protein corona, metal-organic framework nanoparticles have inadequate accumulation in tumor tissues, limiting their therapeutic effects. In this work, pH-responsive linker (L) is prepared by covalently modifying oleylamine (OA) with 3-(bromomethyl)-4-methyl-2,5-furandione (MMfu) poly(ethylene glycol) (PEG). Then, L embedded into solid lipid nanoshell to coat apilimod (Ap)-loaded zeolitic...
There is an urgent demand for wound healing biomaterials because of the increasing frequency traffic accidents, industrial contingencies, and natural disasters. Borate bioactive glass has potential applications in bone tissue engineering healing; however, its uncontrolled release runs a high risk rapid degradation transient biotoxicity. In this study, novel organic–inorganic dressing copper-doped borate glass/poly(lactic-co-glycolic acid) loaded with vitamin E (0–3.0 wt % E) was fabricated...
The hypoxia-inducible factor 1-alpha (HIF-1a) pathway plays a key role in regulating angiogenesis during wound healing. However, the diabetic condition hampers stabilization of HIF-1a and thus inhibits subsequent angiogenesis, meanwhile, function phenotype transition macrophage are impaired condition, which leads to prolonged chronic inflammation. Both inhibition inflammatory dysfunction make healing major clinical challenge. Here, borosilicate (BS), new group bioceramics with coupled...
Critical bone defects caused by extensive excision of malignant tumor and the probability recurrence due to residual cells make treatment a major clinical challenge. The present therapeutic strategy concentrates on implanting substitutes for defect filling but suffers from failures in both enhancing regeneration inhibiting growth cells. Herein, Cu Mn-doped borosilicate nanoparticles (BSNs) were developed syncretic repairing anti-tumor treatment, which can enhance through osteogenic effects...
Background: In the field of tissue engineering, there is currently increasing interest in new biomedical materials with high osteogenic ability and comparable mechanical function to repair bone defects.Three-dimensional (3-D) bioactive borosilicate glass (BG) scaffolds exhibit uniform interconnected macro-pores, porosity compressive strength.In this study, we fabricated 3-D BG by 3D printing technique, then coated surface mesoporous (MBG) (BG-MBG scaffold).Methods: The biocompatibility...
Abstract Due to the deficiency of mechanical supporting after discectomy and weak proliferative capacity annulus fibrosus (AF) cells, AF defect repair remains a clinical challenge. Herein, myofibroblasts derived extracellular vesicles (M‐EVs) functional “brick‐cement” bio‐integrated system (M‐EVs@PGBgel) is developed defect. The modified Poly(glycerol‐sebacate) (PGBS), “bio‐brick” layer, exhibited excellent support features on account its elastomeric properties. loaded M‐EVs in “bio‐cement”...
The high surface area ratio and special structure of mesoporous bioactive glass (MBG) endow it with excellent physical adsorption various drugs without destroying the chemical activity. Silicate 1393 (1393) is famous for its fantastic biodegradability osteogenesis. Herein, we have built a novel vehicle-like drug delivery 3D printing scaffold multiplexed capacity by coating MBG on (1393@MBG). Furthermore, applied DEX BMP-2 1393@MBG to antibacterial osteogenic properties. Results indicated...
ABSTRACT Basic oxygen furnace (BOF) slag and flue gas desulfurization (FGD) residues both are industrial wastes. Research on using BOF as a novel aggregate FGD filler in road construction has benefits environment economics. The main objective of this research was to evaluate the effect fatigue performance moisture resistance asphalt mixtures. mixture conducted by means indirect tensile test. Stress loading control mode, with four stress levels (300, 400, 500 600 kPa), used research....
A novel injectable bone cement was prepared using sol–gel derived borosilicate bioactive glass nanoparticles as a solid phase and sodium alginate solution liquid phase. The gelation reaction of the modulated by Ca2+ ions released from phase, which in turn greatly depended on boron content Such not only significantly enhanced anti-washout property cements, but also allowed control setting, handling properties, compressive strength composite cements. Consequently, cements with controllable...
Moisture damage has a significant negative impact on asphalt and the behaviour of pavement. It exacerbates service performance (e.g. rutting, cracking) mixture. This paper investigated influence flue gas desulphurisation ash (FGDA) mixture moisture damage. First, properties FGDA were characterised by scanning electron microscopy (SEM), X-ray diffraction (XRD), fluorescence differential calorimetry (DSC). To investigate effect damage, limestone powder (LSP) in mortars or mixtures was replaced...
Abstract Traditional high‐dose antibiotic treatments of intracellular methicillin‐resistant staphylococcus aureus (MRSA) are highly inefficient and associated with a high rate infection relapse. As an effective antibacterial technology, sonodynamic therapy (SDT) may be able to break the dilemma. However, indiscriminate reactive oxygen species (ROS) release leads potential side effects. This study incorporates Staphylococcal Protein A antibody‐modified Cu 2+ /tetracarboxyphenylporphyrin...
Tumor Therapy A pH-responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co-workers in article number 2203915, based on acid-induced conversion from hydrophilicity to hydrophobicity, leading aggregated nanoparticles. These nanoparticles inhibit tumor growth reactivate the microenvironment both pancreatic breast cancer models.