A5073036868- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Analytical Methods in Pharmaceuticals
- biodegradable polymer synthesis and properties
- Pharmaceutical studies and practices
- Protein purification and stability
- Analytical Chemistry and Chromatography
- Microencapsulation and Drying Processes
- Advanced Drug Delivery Systems
- Rheology and Fluid Dynamics Studies
- Crystallography and molecular interactions
- Advancements in Transdermal Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Energetic Materials and Combustion
- Advanced Cellulose Research Studies
- Powder Metallurgy Techniques and Materials
- Biopolymer Synthesis and Applications
- CAR-T cell therapy research
- Mineralogy and Gemology Studies
- Advanced Polymer Synthesis and Characterization
- Adsorption, diffusion, and thermodynamic properties of materials
- Material Dynamics and Properties
- Chemical and Physical Properties in Aqueous Solutions
- Cultural Heritage Materials Analysis
Orion Corporation (Finland)
2008-2025
Orion Corporation (United Kingdom)
2006-2009
Kuopio University Hospital
2008
University of Eastern Finland
2004-2005
University of Groningen
2000-2004
The cocrystal formation potential of itraconazole, a potent antifungal drug, with C2–C10 aliphatic dicarboxylic acids has been investigated. Using two experimental screening techniques (solvent-assisted grinding and evaporation-based crystallization), the cocrystals itraconazole C2–C7 have successfully synthesized characterized by powder X-ray diffraction, solid state nuclear magnetic resonance, Raman spectroscopy, thermal analysis. multicomponent compounds include anhydrous (malonic,...
There is a growing demand for chimeric antigen receptor (CAR) -T cells clinical trials. Consequently, new centers capable of manufacturing advanced therapy medicinal products (ATMPs) are needed. In this study, we established good practice -compliant process and phase-appropriate analytics novel autologous CD19-targeted CAR T-cell product, 19-FiCART. We evaluated the stability fresh, healthy donor-derived leukapheresis (LPs), produced 19-FiCART using 12-day semi-automated with...
Improving the solubility of poorly water-soluble drugs is essential for enhancing bioavailability, formulation flexibility and reducing patient-to-patient variability. The preparation amorphous solid dispersions (ASDs) an attractive strategy to formulate such drugs, leading higher apparent water therefore bioavailability. For ASDs, polymer excipients, as poly(vinyl pyrrolidone) (PVP) or pyrrolidone-co-vinyl acetate) (P(VP-co-VA)), are employed solubilize stabilize drug against...
Our objectives were to stabilize a non-clinical suspension for use in toxicological studies and develop methods investigate the stability of formulation terms salt disproportionation. The compound under research was hydrochloride practically insoluble discovery ODM-203. first three approaches prepared stored at room temperature. second stabilized by pH adjustment. In third approach cooling used prevent 5 mg/mL aqueous consisting 20 PVP/VA Tween 80 each approaches. polymer as precipitation...
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging dynamic phase phenomena amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS fast spectral focusing to analyze ASD behavior upon contact dissolution medium. Multivariate unmixing spectra allowed changes distributions drug, polymer...
Improving the solubility of poorly water-soluble drugs is essential for enhancing bioavailability, formulation flexibility and reducing patient-to-patient variability. The preparation amorphous solid dispersions (ASDs) an attractive strategy to formulate such drugs, leading higher apparent water therefore bioavailability. For ASDs, polymer excipients, as poly(vinyl pyrrolidone) (PVP) or pyrrolidone-co-vinyl acetate) (P(VP-co-VA)), are employed solubilize stabilize drug against...
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically specific imaging dynamic phase phenomena amorphous solid dispersions (ASDs). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0–100% w/w) as model systems, we employed SRS fast spectral focusing to analyze ASD behavior upon contact a dissolution medium. Multivariate unmixing spectra allowed changes distributions drug, polymer,...