A5101445657- Antifungal resistance and susceptibility
- Gut microbiota and health
- Retinal and Macular Surgery
- Fungal Biology and Applications
- Radiomics and Machine Learning in Medical Imaging
- Calpain Protease Function and Regulation
- Fungal Infections and Studies
- Plant-Microbe Interactions and Immunity
- Antimicrobial Peptides and Activities
- Pneumonia and Respiratory Infections
- Parasites and Host Interactions
- Retinal Diseases and Treatments
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Signaling Pathways in Disease
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Mycorrhizal Fungi and Plant Interactions
- Intraocular Surgery and Lenses
- Forest, Soil, and Plant Ecology in China
- Enhanced Recovery After Surgery
- Plant Pathogens and Fungal Diseases
- Antibiotic Use and Resistance
- Infection Control and Ventilation
Guangzhou University of Chinese Medicine
2024
Sun Yat-sen University
2008-2024
Institute of Botany
2023-2024
Beijing Botanical Garden
2023-2024
University of Chinese Academy of Sciences
2023-2024
Institut Pasteur of Shanghai
2017-2023
Chinese Academy of Sciences
2017-2023
China National Botanical Garden
2023
Huzhou Women and Children's Hospital
2016-2020
Fuzhou Second Hospital
2018
Abstract Severe acute respiratory syndrome (SARS) is primarily transmitted by bio-aerosol droplets or direct personal contacts. This paper presents a detailed study of environmental evidence possible airborne transmission in hospital ward during the largest nosocomial SARS outbreak Hong Kong March 2003. Retrospective on-site inspections and measurements ventilation design air distribution system were carried out on July 17, Limited dispersion also 22. Computational fluid dynamics simulations...
Abstract Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects C. , its interaction with host immune system only now beginning to be investigated in-depth. Here, we compare innate responses induced by BJCA001 albicans SC5314 in vitro vivo. Our results indicate that appears less immunoinflammatory than SC5314, this differential response...
Acinetobacter baumannii (AB) is critical for healthcare-associated infections (HAI) with significant regional differences in the resistance rate, but its risk factors and infection trends has not been well studied. We aimed to explore factors, epidemiological characteristics of multidrug-resistant (MDR-AB) intensive care unit inpatients.Data patients MDR-AB (195 cases), antibiotic-sensitive AB (294 cases, control) during January December, 2015 three medical centers Xiamen, China were...
FERONIA (FER) is a receptor-like kinase showing versatile functions during plant growth, development, and responses to environmental stimuli. However, its the interaction between fruit necrotrophic fungal pathogens are still unclear. Combining reverse genetic approaches, physiological assays, co-immunoprecipitation, protein phosphorylation identification, site-directed mutagenesis, we reported tomato FER homolog SlFERL (Solanum lycopersicum Like) involved in immune Botrytis cinerea invasion....
Efficient assimilation of alternative carbon sources in glucose-limited host niches is critical for colonization Candida albicans, a commensal yeast that frequently causes opportunistic infection human. C. albicans evolved mechanistically to regulate the promotion fungal growth and commensalism mammalian hosts. However, this highly adaptive mechanism employs cope with has yet be clearly understood. Here we identified novel role mitochondrial complex I (CI) regulating such as mannitol. Our...
To investigate the characteristics of rhegmatogenous retinal detachment associated with choroidal (RRDCD) in a Chinese population by using ultrasound biomicroscope (UBM).A random prospective study was used to assess 1,389 patients (1,408 eyes) detachment. Comprehensive standardized ophthalmic examinations included intraocular pressure (IOP) Goldmann applanation tonometer and entire ocular fundus three-mirror lens, B-type ultrasound, UBM.A total participated study, including 906 men 483...
Yeast two-hybrid experiments identified alpha(2)-Heremans-Schmid glycoprotein (human fetuin A) as a binding partner for calpain domain III (DIII). The tandem DIIIs of calpain-10 interacted under the most selective culture conditions, but m-calpain, calpain-3, and calpain-5 also less stringent selection. mu-calpain, calpain-6, DIII-like domains Dictyostelium Cpl protein did not interact with in yeast system. Bovine A stabilized proteolytic activity purified m-calpain incubated presence mm...
Laparoscopic total hysterectomy is performed by carbon dioxide insufflation, Trendelenburg position and mechanical ventilation of patients under general anesthesia. However, this may induce pulmonary atelectasis and/or hyperdistention the lungs. Multiple studies have indicated that with use low tidal volumes, moderate positive end-expiratory pressure (PEEP) regular alveolar recruitment maneuvers improve post-operative outcomes. benefits an individualized level PEEP not been clearly...
Successful host colonization by fungi in fluctuating niches requires response and adaptation to multiple environmental stresses. However, our understanding about how fungal species thrive the gastrointestinal (GI) ecosystem combing multifaceted nutritional stress with respect homeostatic host-commensal interactions is still its infancy. Here, we discover that depletion of phosphate transceptor Pho84 across encountered a substantial cost colonization. Mechanistically, enhances commensalism...
With the worsening of greenhouse effect, correlation between damp-heat environment (DH) and incidence various diseases has gained increasing attention. Previous studies have demonstrated that DH can lead to intestinal disorders, enteritis, an up-regulation NOD-like receptor protein 3 (NLRP3). However, mechanism NLRP3 in this process remains unclear.
Background Neural apoptosis is generally believed to be mediated by two distinct pathways, caspase-dependant and caspase-independent pathways. This study investigated the apoptotic pathways involved in retinal ganglion cells acute diabetes rats. Methods Diabetes was induced male Wistar rats a peritoneal injection of streptozotocin (STZ). Expression localization caspase-3 apoptosis-inducing factor (AIF) proteins retina diabetic examined Western blotting immunohistochemistry analyses. Terminal...
Calpains are intracellular, cysteine proteases found in plants, animals, and fungi. There is emerging evidence that they important mediators of cell adhesion motility animal cells. Because the cellular slime mold, Dictyostelium discoideum, a genetically tractable model for motility, we have investigated whether calpain-like protein expressed this organism. Contig 13130 (Sanger Institute sequencing project) was identified as three-exon gene encodes protein. Using custom peptide antibody to...
The transcriptional regulator Pdr1 plays a positive role in regulating azole drug resistance Candida glabrata. Previous studies have shown the importance of carboxyl (C)-terminal sequence fulfilling its function, as this region mediates interactions between and co-activator Gal11A is crucial for activation targets. However, mechanisms how regulated, especially implication C-terminus regulatory activity, remain uncharacterized. In study, we unexpectedly observed that C-terminal modification...
子宫内膜癌是女性生殖系统三大恶性肿瘤之一。在欧美国家，子宫内膜癌的发病率已居女性生殖系统恶性肿瘤的首位，在我国也呈现上升趋势。如何在人群中筛选出子宫内膜癌前病变及早期子宫内膜癌，提高子宫内膜癌的筛查效率，实现子宫内膜癌的早发现、早诊断、早治疗，已势在必行。本建议根据我国子宫内膜癌的诊治经验及筛查现状，结合国际筛查指南及国内外文献，经过中国医师协会妇产科学分会各位专家多次讨论，对于子宫内膜癌的筛查及早期诊断达成了新的规范建议。.
Objective To compare the effects of allogeneic blood transfusion and hemodiluted autotransfusion on cellular immune function in patients undergoing cesarean section. Methods Sixty patients, aged 20-35 yr, weighing 50-80 kg, American Society Anesthesiologists physical statusⅠ or Ⅱ, scheduled for elective section, were randomly divided into 2 groups(n = 30 each)using a random number table: group(group HAT)and ABT). Both groups received epidural anesthesia.The radial artery was...
Aims To evaluate the visual function and foveal architecture in patients with stage 3 idiopathic epiretinal membrane (iERM). Methods A cross-sectional observational study included 56 eyes of 52 iERM. The were classified into type ectopic inner layers (EIFL) B EIFL based on presence a continuous hyporeflective band. Visual microarchitecture assessed enrolled eyes. Best-corrected acuity (BCVA), metamorphopsia scores, retinal sensitivity optical coherence tomography (OCT)/OCT angiography...
女性慢性盆腔痛（CPP）是定位于盆腔的持续6个月以上的疼痛，患病率高，病因涉及多个器官、系统，常伴有心理变化，严重影响患者的身心健康，诊治极为复杂，目前国内尚缺乏相应的诊治指南。本共识是在参考国际指南的基础上，结合国内的临床实践经验，由妇科、泌尿科、消化科、疼痛科、影像科、心理学及基础神经生物学等多学科专家共同讨论制定，详细阐述了CPP的评估（包括详细询问病史、系统全面查体、针对性的辅助检查以及疼痛、心理评估）、诊断和治疗（包括患者教育、药物治疗、康复治疗、介入治疗、手术治疗、补充和替代治疗、精神心理治疗和多学科综合治疗）等方面，并给出了19条推荐意见，旨在为这一复杂病症提供诊治思路以及为临床工作提供指导。.