A5003642570- MicroRNA in disease regulation
- Cancer-related gene regulation
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Multiple Myeloma Research and Treatments
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Vitamin K Research Studies
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- Electrospun Nanofibers in Biomedical Applications
- Palliative Care and End-of-Life Issues
- Connective tissue disorders research
- Pneumonia and Respiratory Infections
- Circular RNAs in diseases
- Hemoglobinopathies and Related Disorders
- Urticaria and Related Conditions
- Aortic aneurysm repair treatments
Carmel Medical Center
2016-2025
Technion – Israel Institute of Technology
2005-2025
Haifa Medical Center
2023
Dartmouth–Hitchcock Medical Center
2010-2018
Dartmouth College
2010-2011
Dartmouth Hospital
2010
University of Copenhagen
2010
Aalborg University
2010
Weatherford College
2007
MicroRNAs (miRNAs) regulate gene expression. It has been suggested that obtaining miRNA expression profiles can improve classification, diagnostic, and prognostic information in oncology. Here, we sought to comprehensively identify the miRNAs are overexpressed lung cancer by conducting microarray profiling on normal versus adjacent cancers from transgenic mice. We found miR-136, miR-376a, miR-31 were each prominently murine cancers. Real-time RT-PCR situ hybridization (ISH) assays confirmed...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Diagnosis and management of PDAC are hampered by the absence sensitive specific disease biomarkers. MicroRNAs (miRNA) noncoding regulatory RNAs involved in initiation progression human cancers. In this study, we sought to determine whether miR-10b could serve as biomarker for PDAC. Experimental Design: miRNA expression was characterized fluorescence-based situ hybridization using locked nucleic...
In this first-in-human, Phase 1, open-label, multicenter study, we evaluated JNJ-64619178, a selective and potent PRMT5 inhibitor, in patients with advanced malignant solid tumors or non-Hodgkin lymphomas (NHL). The primary objective was to evaluate the safety identify recommended 2 dose (RP2D) of JNJ-64619178.Adult treatment-refractory NHL measurable disease received escalating doses JNJ-64619178 following two schedules (Schedule A: 14 days on/7 off; Schedule B: every day on 21-day cycle)....
Abstract Purpose: High-throughput profiling experiments have linked altered expression of microRNAs (miRNA) to different types cancer. Tumor tissues are a heterogeneous mixture not only cancer cells, but also supportive and reactive tumor microenvironment elements. To clarify the clinical significance miRNA in solid tumors, we developed sensitive fluorescence-based situ hybridization (ISH) method visualize accumulation within individual cells formalin-fixed, paraffin-embedded tissue...
Abstract The phase 3 SELENE study evaluated ibrutinib + chemoimmunotherapy (CIT; bendamustine and rituximab [BR]; or rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone [R-CHOP]) for patients with relapsed/refractory (R/R) follicular lymphoma (FL) marginal zone (MZL). Adult who had received ≥1 prior line of CIT were randomized 1:1 to oral (560 mg) placebo daily, plus 6 cycles BR/R-CHOP. primary end point was investigator-assessed progression-free survival (PFS). Overall, 403 (n...
Multi-refractory immune thrombocytopenia (ITP) is not uncommon and associated with high morbidity mortality rates. Although the precise mechanism of ITP yet fully understood, a therapeutic approach that relies on using single agent in each treatment line may be sufficient this population. We report case 67-year-old female long-standing multi-refractory treated combination Daratumumab Romiplostim who achieved durable response for more than 42 weeks. Owing to presentation chronic refractory...
The aim of this study was to examine the association homozygosity for methylenetetrahydrofolate reductase (MTHFR) C677T mutation and vitamin B12 deficiency in 360 asymptomatic individuals investigate forearm endothelial function homozygotes. MTHFR levels B12, folic acid, homocysteine were measured participants. Frequency 67/360 (18.6%). Homocysteine elevated homozygous compared with heterozygous subjects or those without (20.6 +/- 18.8 vs. 9.4 3.2 mumol/l; P < 0.0001). number (<150 pmol/l)...
Keloid scar is pathological tissue that appears after skin injury, and more aggressive than hypertrophic scars. scars are characterized by increased proliferation of fibroblast-like cells (FLCs) the accumulation extracellular matrix, mainly collagen. Fibulin-5, a glycoprotein secreted many cell types, component matrix. We investigated effect fibulin-5 on adhesion FLCs derived from keloid role integrin beta-1 in these activities.Fibroblast-like were isolated six cultured plates coated with or...
Background: One of the main obstacles providing home-based palliative care to transfusion-dependent hematology patients is lack home transfusions services. While healthcare professionals are concerned with safety and cost transfusions, attitude toward mostly unknown. Aim: To obtain quantitative data regarding willingness concerns hematological diseases option transfusions. Design: A cross sectional survey including a self-administered questionnaire in one three spoken languages Israel was...